INT148846

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Context Info
Confidence 0.26
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 1.67
Pain Relevance 2.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (MAP3K3)
MAP3K3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammatory stimuli 5 99.84 Very High Very High Very High
cytokine 40 99.52 Very High Very High Very High
Inflammation 33 99.12 Very High Very High Very High
chemokine 4 97.56 Very High Very High Very High
Endogenous opioid 1 97.20 Very High Very High Very High
Opioid 9 95.68 Very High Very High Very High
analgesia 4 91.92 High High
substance P 1 91.84 High High
IPN 3 86.36 High High
Endocannabinoid 1 85.96 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 36 99.84 Very High Very High Very High
Obesity 106 94.76 High High
Adhesions 2 90.04 High High
Inflammatory Pain 3 86.36 High High
Pain 3 76.72 Quite High
Cancer 5 50.00 Quite Low
Necrosis 3 50.00 Quite Low
Diabetes Mellitus 8 27.08 Quite Low
Insulin Resistance 10 5.00 Very Low Very Low Very Low
Hypertension 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Secretion requires intracellular calcium mobilization and activation of phosphinositol-3 kinase and p38 mitogen activated kinase.
Positive_regulation (activation) of phosphinositol-3 kinase
1) Confidence 0.26 Published 2007 Journal Curr Rheumatol Rep Section Abstract Doc Link 18177605 Disease Relevance 0.48 Pain Relevance 1.18
The release is dependent on intracellular calcium and activation of phosphoinositol-3 kinase and p38 mitogen activated kinase.
Positive_regulation (activation) of phosphoinositol-3 kinase
2) Confidence 0.02 Published 2008 Journal Br J Anaesth Section Abstract Doc Link 18397920 Disease Relevance 0.33 Pain Relevance 1.15
Among the MAP3Ks that regulate the ERK pathway, Tpl2 is more specifically activated by inflammatory stimuli (26,32).
Positive_regulation (activated) of MAP3Ks associated with inflammatory stimuli
3) Confidence 0.01 Published 2010 Journal Diabetes Section Body Doc Link PMC2797946 Disease Relevance 0.86 Pain Relevance 0.26

General Comments

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