INT148864

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Context Info
Confidence 0.17
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 11
Total Number 11
Disease Relevance 7.67
Pain Relevance 8.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (DRGX)
Anatomy Link Frequency
neurons 9
dorsal root ganglion 1
DRGX (Homo sapiens)
Pain Link Frequency Relevance Heat
dorsal root ganglion 257 100.00 Very High Very High Very High
Calcitonin gene-related peptide 53 100.00 Very High Very High Very High
Glutamate 30 100.00 Very High Very High Very High
hyperexcitability 18 100.00 Very High Very High Very High
Root ganglion neuron 2 100.00 Very High Very High Very High
gABA 2 99.98 Very High Very High Very High
Nav1.7 79 99.82 Very High Very High Very High
Paroxysmal extreme pain disorder 61 99.74 Very High Very High Very High
qutenza 47 99.20 Very High Very High Very High
Pain 132 98.96 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ganglion Cysts 333 100.00 Very High Very High Very High
Somatoform Disorder 63 99.74 Very High Very High Very High
Generalized Anxiety Disorder 3 99.64 Very High Very High Very High
Erythermalgia 59 98.16 Very High Very High Very High
Nociception 74 97.04 Very High Very High Very High
Pain 131 96.00 Very High Very High Very High
Injury 30 95.44 Very High Very High Very High
Alopecia 6 92.64 High High
Frailty 6 92.24 High High
Hyperalgesia 11 91.68 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We also found that subcutaneous inoculation of rdvGAD67 resulted in enhanced production of GAD and tonical GABA release from transduced DRG neurons.
Localization (release) of DRG in neurons associated with dorsal root ganglion, gaba and generalized anxiety disorder
1) Confidence 0.17 Published 2008 Journal Neurosci. Lett. Section Abstract Doc Link 18180106 Disease Relevance 1.38 Pain Relevance 0.99
These changes of the biophysical properties of NaV1.7 are expected to contribute to hyperexcitability of DRG neurons, which underlies painful symptoms of erythromelalgia.
Localization (hyperexcitability) of DRG in neurons associated with pain, erythermalgia and hyperexcitability
2) Confidence 0.13 Published 2008 Journal Mol Pain Section Body Doc Link PMC2262064 Disease Relevance 0.32 Pain Relevance 0.21
Together with our results showing similar IC50 of ranolazine block of WT and mutant Nav1.7 peak currents, these data suggests that ranolazine may not have a preferential effect in blocking mutant Nav1.7-induced DRG hyperexcitability.
Localization (hyperexcitability) of DRG associated with dorsal root ganglion, hyperexcitability and nav1.7
3) Confidence 0.11 Published 2010 Journal Mol Pain Section Body Doc Link PMC2898769 Disease Relevance 0.30 Pain Relevance 0.92
In addition to its co-localization with TRPV1 in small/medium diameter sensory neurons of the dorsal root ganglion (DRG), the number of both TRPV3- and TRPV1- immunoreactive sensory neurons increased significantly after DRG avulsion injury i.e. central axotomy [4].
Localization (localization) of DRG in dorsal root ganglion associated with ganglion cysts, dorsal root ganglion and injury
4) Confidence 0.08 Published 2007 Journal BMC Neurol Section Body Doc Link PMC1892784 Disease Relevance 0.74 Pain Relevance 0.62
Also, while it is predicted that impaired fast-inactivation could be linked to repetitive firing in hyperexcitable DRG neurons [26], the effects of the PEPD mutation on DRG neuron excitability have not been experimentally demonstrated.
Localization (excitability) of DRG neuron in neuron associated with dorsal root ganglion, repetitive firing and paroxysmal extreme pain disorder
5) Confidence 0.08 Published 2008 Journal Mol Pain Section Body Doc Link PMC2556659 Disease Relevance 0.76 Pain Relevance 0.82
In functional studies, ABT-102 blocks capsaicin-evoked calcitonin gene-related peptide release from rat DRG neurons.
Localization (release) of DRG in neurons associated with dorsal root ganglion, qutenza and calcitonin gene-related peptide
6) Confidence 0.03 Published 2008 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 18515644 Disease Relevance 0.56 Pain Relevance 1.19
RK, at concentrations higher than 1 microM, significantly increased CGRP release from dorsal root ganglion neurons (DRG) isolated from wild-type (WT) mice and this increase was completely reversed by capsazepine, an inhibitor of vanilloid receptor-1 activation.
Localization (release) of DRG in neurons associated with ganglion cysts, root ganglion neuron and calcitonin gene-related peptide
7) Confidence 0.02 Published 2008 Journal Growth Horm. IGF Res. Section Abstract Doc Link 18321745 Disease Relevance 0.53 Pain Relevance 0.37
UTP has been shown to stimulate CGRP release from rat DRG neurons in the absence of extracellular Ca2+, and suramin abolished this stimulatory action [21].
Localization (release) of DRG in neurons associated with dorsal root ganglion and calcitonin gene-related peptide
8) Confidence 0.01 Published 2004 Journal Purinergic Signal Section Body Doc Link PMC2096565 Disease Relevance 0.82 Pain Relevance 0.73
The P2Y1 receptor further inhibits VACCs, which play a role in the vesicular release of glutamate from DRG neurons.
Localization (release) of DRG in neurons associated with dorsal root ganglion and glutamate
9) Confidence 0.01 Published 2004 Journal Purinergic Signal Section Body Doc Link PMC2096565 Disease Relevance 0.59 Pain Relevance 1.00
In contrast, in a more detailed study, neither ATP, UTP nor 2-MeSATP increased the basal release of SP or CGRP from cultured embryonic rat DRG neurons [55].
Localization (release) of DRG in neurons associated with dorsal root ganglion and calcitonin gene-related peptide
10) Confidence 0.01 Published 2004 Journal Purinergic Signal Section Body Doc Link PMC2096565 Disease Relevance 0.72 Pain Relevance 0.88
PAP is extensively co-localized with the ATP receptor P2X3 and is co-localized in 14.4% of all TRPV1+ DRG neurons in the mouse [3].
Localization (localized) of DRG in neurons
11) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2617779 Disease Relevance 0.94 Pain Relevance 0.63

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