INT14887

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Context Info
Confidence 0.75
First Reported 1980
Last Reported 2010
Negated 2
Speculated 1
Reported most in Abstract
Documents 55
Total Number 56
Disease Relevance 36.13
Pain Relevance 16.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Mbp)
Anatomy Link Frequency
oligodendrocytes 5
CSF 4
spinal cord 4
T-cell 4
heart 3
Mbp (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 128 100.00 Very High Very High Very High
Neuritis 85 100.00 Very High Very High Very High
Clonidine 13 99.98 Very High Very High Very High
Serotonin 4 99.90 Very High Very High Very High
Spinal cord 207 99.84 Very High Very High Very High
intrathecal 18 99.76 Very High Very High Very High
Enkephalin 2 99.68 Very High Very High Very High
Demyelination 20 99.04 Very High Very High Very High
Multiple sclerosis 156 98.96 Very High Very High Very High
substance P 6 98.90 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cancer 35 100.00 Very High Very High Very High
Experimental Autoimmune Neuritis 26 100.00 Very High Very High Very High
Munchausen Syndrome 7 100.00 Very High Very High Very High
Necrosis 6 100.00 Very High Very High Very High
Optic Neuritis 54 99.84 Very High Very High Very High
Demyelinating Disease 114 99.28 Very High Very High Very High
Neuromyelitis Optica 14 98.96 Very High Very High Very High
Disease 149 98.92 Very High Very High Very High
Multiple Sclerosis 433 98.62 Very High Very High Very High
Syndrome 36 98.60 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Repeated injections of MR 2034 given during the whole period of observation produced the most pronounced suppression of EAE clinical signs, histological lesions in the brain and spinal cord, and anti-myelin basic protein antibody production.
Gene_expression (production) of myelin basic protein in brain associated with multiple sclerosis and spinal cord
1) Confidence 0.75 Published 1994 Journal Neuroimmunomodulation Section Abstract Doc Link 7489338 Disease Relevance 0.50 Pain Relevance 0.21
CSF measurements included immunoglobulin G (IgG) synthesis, IgG ratio, myelin basic protein, IgG kappa light chains, and oligoclonal banding.
Gene_expression (synthesis) of myelin basic protein
2) Confidence 0.74 Published 1996 Journal Neurology Section Abstract Doc Link 8614496 Disease Relevance 1.34 Pain Relevance 0.87
MBP is suggested by symptoms that do not follow the usual course of illness, particularly if the symptoms only occur in the presence of the same person.
Gene_expression (suggested) of MBP associated with munchausen syndrome
3) Confidence 0.67 Published 1989 Journal Health Soc Work Section Abstract Doc Link 2707683 Disease Relevance 0.77 Pain Relevance 0.10
Numbers of AChR-, MBP-, BPM-reactive Th1 type of cytokine interferon (IFN)-gamma, tumor necrosis factor (TNF)-alpha mRNA expression in lymph node cells were markedly suppressed, while transforming growth factor-beta (TGF-beta) mRNA expression was upregulated from nasally tolerized rats, suggesting an active suppression mechanism may act partly in the induction of tolerance.
Gene_expression (expression) of MBP in lymph node associated with necrosis, cancer, tolerance and cytokine
4) Confidence 0.62 Published 1998 Journal J. Neurol. Sci. Section Abstract Doc Link 9562316 Disease Relevance 1.13 Pain Relevance 0.49
We report that ALC treatment: (1) upregulates lysosomal H(+)/ATPase gene expression and (2) downregulates myelin basic protein gene expression.
Gene_expression (expression) of myelin basic protein gene
5) Confidence 0.60 Published 2008 Journal Mol. Neurobiol. Section Abstract Doc Link 18726077 Disease Relevance 0.51 Pain Relevance 0.08
MBP-autoantibodies were only detected in two and S100beta-autoantibodies in one patient.
Gene_expression (detected) of MBP
6) Confidence 0.60 Published 2001 Journal Neurosci. Lett. Section Abstract Doc Link 11427318 Disease Relevance 0.86 Pain Relevance 0.12
The role of the HLA system in anti-MBP antibody production in ON was investigated employing a restriction fragment length polymorphism system for genomic HLA-DQ and -DR typing and an immunospot assay for the detection of individual cells secreting antibodies to three different synthetic MBP peptides.
Gene_expression (production) of MBP associated with neuritis
7) Confidence 0.60 Published 1994 Journal Scand. J. Immunol. Section Abstract Doc Link 7516573 Disease Relevance 1.01 Pain Relevance 0.70
OBJECTIVE: To study the intrathecal synthesis of anti-myelin basic protein (MBP) and anti-proteolipid protein (PLP) antibodies in patients in the early stages of multiple sclerosis.
Gene_expression (synthesis) of MBP associated with multiple sclerosis and intrathecal
8) Confidence 0.57 Published 1994 Journal Arch. Neurol. Section Abstract Doc Link 7524468 Disease Relevance 0.17 Pain Relevance 0.17
Mean blood pressure (MBP), heart rate (HR), and BIS value were recorded before induction of anesthesia (B0), after loss of consciousness (B1), before intubation, during intubation (L0), 1, 2 and 5 min after intubation (L1, 2, and L5).
Gene_expression (pressure) of MBP in heart associated with anesthesia and unconsciousness
9) Confidence 0.54 Published 2010 Journal Korean Journal of Anesthesiology Section Body Doc Link PMC2966706 Disease Relevance 0.27 Pain Relevance 0.32
OPCs were identified by NG2 positive cells, while myelinating oligodendrocytes were detected by cyclic nucleotide phosphodiesterase (CNPase) or myelin basic protein (MBP) immunoreactive cells [20].
Gene_expression (detected) of MBP in oligodendrocytes
10) Confidence 0.54 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2884017 Disease Relevance 0.41 Pain Relevance 0.05
OPCs were identified by NG2 positive cells, while myelinating oligodendrocytes were detected by cyclic nucleotide phosphodiesterase (CNPase) or myelin basic protein (MBP) immunoreactive cells [20].
Gene_expression (detected) of myelin basic protein in oligodendrocytes
11) Confidence 0.54 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2884017 Disease Relevance 0.41 Pain Relevance 0.05
In normal hydrated rats, intracerebroventricularly (i.c.v.) injected clonidine (10 and 20 micrograms) produced a dose-dependent and long-lasting rise in mean blood pressure (MBP) concomitant with a decrease in heart rate.
Gene_expression (produced) of MBP in heart associated with clonidine
12) Confidence 0.53 Published 1987 Journal Life Sci. Section Abstract Doc Link 3573988 Disease Relevance 0.07 Pain Relevance 0.48
Detection of brain-specific autoantibodies to myelin oligodendrocyte glycoprotein, S100beta and myelin basic protein in patients with Devic's neuromyelitis optica.
Gene_expression (Detection) of myelin basic protein in oligodendrocyte associated with neuromyelitis optica
13) Confidence 0.52 Published 2001 Journal Neurosci. Lett. Section Title Doc Link 11427318 Disease Relevance 1.01 Pain Relevance 0.14
Anti-P2 protein and anti-MBP antibodies were detected not only in the EAN rabbits but also in the nonresponders.
Gene_expression (detected) of MBP associated with neuritis
14) Confidence 0.51 Published 1986 Journal Jpn. J. Exp. Med. Section Abstract Doc Link 2426483 Disease Relevance 0.73 Pain Relevance 0.76
OBJECTIVE: To study the intrathecal synthesis of anti-myelin basic protein (MBP) and anti-proteolipid protein (PLP) antibodies in patients in the early stages of multiple sclerosis.
Gene_expression (synthesis) of anti-myelin basic protein associated with multiple sclerosis and intrathecal
15) Confidence 0.50 Published 1994 Journal Arch. Neurol. Section Abstract Doc Link 7524468 Disease Relevance 0.17 Pain Relevance 0.17
CNPase is a prenylated myelin protein and MBP is an abundant protein component of the myelin sheath, which are highly expressed in mature oligodendrocytes [50], [51].
Gene_expression (expressed) of MBP in oligodendrocytes
16) Confidence 0.48 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2884017 Disease Relevance 0.08 Pain Relevance 0.09
Confocal images of the nervous area inside the conduit revealed noteworthy distribution of regenerated myelinated fascicles (MBP, CNPase, ?
Gene_expression (fascicles) of MBP in fascicles
17) Confidence 0.44 Published 2008 Journal BMC Biotechnol Section Body Doc Link PMC2358889 Disease Relevance 0.24 Pain Relevance 0
(D) MBP-specific antibody production remains unchanged after BZ194 treatment.
Gene_expression (production) of MBP-specific
18) Confidence 0.42 Published 2010 Journal Brain Section Body Doc Link PMC2892943 Disease Relevance 0.18 Pain Relevance 0.10
To this end, we generated MBP-specific CD4+ T cell lines (Ben-Nun et al., 1981).
Gene_expression (generated) of MBP-specific in T cell
19) Confidence 0.42 Published 2010 Journal Brain Section Body Doc Link PMC2892943 Disease Relevance 0.31 Pain Relevance 0.44
After isolation, both DLNC and SCC were cultivated for 72 hours with MBP (10 ?
Gene_expression (hours) of MBP in SCC associated with spinal cord
20) Confidence 0.41 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2525626 Disease Relevance 0.28 Pain Relevance 0.24

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