INT148879

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Context Info
Confidence 0.04
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.95
Pain Relevance 0.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

unfolded protein binding (LMAN1) protein folding (LMAN1) vesicle-mediated transport (LMAN1)
Golgi apparatus (LMAN1) endoplasmic reticulum (LMAN1)
Anatomy Link Frequency
T-cell 1
LMAN1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 29 99.10 Very High Very High Very High
cytokine 2 56.88 Quite High
reflex sympathetic dystrophy 5 50.00 Quite Low
Inflammatory mediators 1 50.00 Quite Low
Neuropeptide 1 10.00 Low Low
metalloproteinase 1 8.88 Low Low
Inflammatory marker 6 5.00 Very Low Very Low Very Low
Restless leg syndrome 1 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
fibrosis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 26 100.00 Very High Very High Very High
INFLAMMATION 37 99.10 Very High Very High Very High
Cardiovascular Disease 44 92.12 High High
Dystonia 2 90.72 High High
Complex Regional Pain Syndromes 5 89.80 High High
Obesity 25 70.48 Quite High
Heart Disease 3 67.64 Quite High
Thinness 1 62.68 Quite High
Infection 18 50.00 Quite Low
Aging 8 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Tsimane and other Amerindians should be comprehensively investigated for distinct inflammation profiles due to genetic variability in loci affecting expression of CRP [39], apolipoprotein-E [40], mannose-binding lectin (MBL) [41], NR4A nuclear receptor family [42], interleukine-6 (IL-6) [43], IL-1 [44], and toll-like receptor 4 [45].
Regulation (affecting) of mannose-binding lectin associated with inflammation and disorder of lipid metabolism
1) Confidence 0.04 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2722089 Disease Relevance 0.77 Pain Relevance 0.15
We measured interleukin-1beta, interleukin-6, interferon-gamma inducible protein-10, RANTES (regulated upon activation, normal T-cell expressed and secreted), complement C3, mannose-binding lectin, complement C1q, soluble intercellular adhesion molecule-1, endothelin-1, nitric oxide, human lactoferrin, and hypocretin-1 levels in these samples.
Regulation (regulated) of mannose-binding lectin in T-cell
2) Confidence 0.03 Published 2008 Journal Clin J Pain Section Body Doc Link 18180633 Disease Relevance 0.18 Pain Relevance 0

General Comments

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