INT14888

Context Info Confidence 0.66 First Reported 1981 Last Reported 2010 Negated 0 Speculated 1 Reported most in Abstract Documents 9 Total Number 10 Disease Relevance 6.90 Pain Relevance 1.65

Anatomy Link Frequency joint 1 blood 1 B-cell 1 bladder 1 heart 1 PSS (Homo sapiens)

Pain Link Frequency Relevance Heat intrathecal 5 99.90 spinal inflammation 11 98.86 Arthritis 10 98.28 rheumatoid arthritis 21 97.74 Multiple sclerosis 4 97.04 Osteoarthritis 40 96.96 Pain 11 93.68 anesthesia 3 90.40 Central nervous system 3 90.32 Potency 1 89.44

Disease Link Frequency Relevance Heat Systemic Lupus Erythematosus 33 100.00 Syndrome 22 100.00 Lymphatic System Cancer 16 100.00 Systemic Sclerosis 9 99.88 Coronary Artery Disease 3 99.74 Mycobacterial Infection 1 99.10 Pressure Volume 2 Under Development 2 99.04 Low Back Pain 11 98.86 Polymyositis 1 98.84 Heart Rate Under Development 1 98.50

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Anatomy

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Speculation

Pain term

Disease term

However, the clinical presentation of PSS may be atypical; 14% of patients in the present series initially sought medical attention for symptoms other than Raynaud's phenomenon, tight skin, or joint pain.

Gene_expression (presentation) of PSS in joint associated with pain and arthralgia

1) Confidence 0.66 Published 1988 Journal Semin. Arthritis Rheum. Section Abstract Doc Link 3187542 Disease Relevance 0.52 Pain Relevance 0.09

The correlation between PSS and lactate production was significant (r = 0.873; SEE = 50.49; P = 0.000001).

Gene_expression (production) of PSS

2) Confidence 0.66 Published 1991 Journal J. Cardiothorac. Vasc. Anesth. Section Abstract Doc Link 1768816 Disease Relevance 0.07 Pain Relevance 0.14

Reasons for drop-outs were very high liver transaminases in three cases, cardiac death in two, and drug allergy, alcoholic problems, suspected congestive heart failure, reactivation of tuberculosis, arteriosclerotic heart disease, and lethal progression of PSS in one case each.

Gene_expression (progression) of PSS in heart associated with mycobacterial infection, heart rate under development, coronary artery disease, drug hypersensitivity and death

3) Confidence 0.57 Published 1981 Journal Acta Med Scand Section Abstract Doc Link 7039242 Disease Relevance 0.97 Pain Relevance 0

PSS produces pain and functional limitation, especially in women.

Gene_expression (produces) of PSS

4) Confidence 0.57 Published 2008 Journal Ortopedia, traumatologia, rehabilitacja Section Body Doc Link 19153543 Disease Relevance 0 Pain Relevance 0

A further reduction in coronary blood flow to 39.84 +/- 5.63 mL/min/100 g resulted in severe PSS (50.62% +/- 6.14%) and lactate production (183.81% +/- 28.80%).

Gene_expression (production) of PSS in blood

5) Confidence 0.51 Published 1991 Journal J. Cardiothorac. Vasc. Anesth. Section Abstract Doc Link 1768816 Disease Relevance 0.07 Pain Relevance 0.14

This has implications for the future engineering of scFv carriers for PDT, in order to control the number and function of the PSs that can be coupled.

Gene_expression (coupled) of PSs

6) Confidence 0.48 Published 2008 Journal Sci Prog Section Abstract Doc Link 18853576 Disease Relevance 0.20 Pain Relevance 0.11

Evidence of clinical efficacy in indolent and aggressive NHL and in both SLE and pSS suggests that epratuzumab is a promising new therapeutic agent for the treatment of B-cell malignancies and B-cell-implicated autoimmune diseases.

Gene_expression (aggressive) of pSS in B-cell associated with autoimmune disease, lymphatic system cancer and systemic lupus erythematosus

7) Confidence 0.15 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2376077 Disease Relevance 0.91 Pain Relevance 0

Persons were asked directly to report any diagnosis of: rheumatoid arthritis (RA), psoriatic arthritis (PsA), ankylosing spondylitis (AS), systemic lupus erythematosus (SLE), primary Sjogren's syndrome (pSS), systemic sclerosis (SSc), polymyositis (PM), dermatomyositis (DM), gout, osteoarthritis (OA), and vasculitis (e.g Do you suffer from rheumatoid arthritis?

Gene_expression (syndrome) of pSS associated with spinal inflammation, syndrome, rheumatoid arthritis, crystal associated disease, dermatomyositis, increased venous pressure under development, systemic sclerosis, systemic lupus erythematosus, seronegative spondarthritis, polymyositis, osteoarthritis and arthritis

8) Confidence 0.10 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2890601 Disease Relevance 2.18 Pain Relevance 0.62

Interestingly, in some PSS patients intrathecal IgG synthesis occurred without overt clinical nervous system involvement and thus the clinical significance of intrathecal IgG synthesis in PSS is uncertain.

Gene_expression (synthesis) of PSS in nervous system associated with syndrome and intrathecal

9) Confidence 0.04 Published 1990 Journal J. Neurol. Sci. Section Abstract Doc Link 1708408 Disease Relevance 1.19 Pain Relevance 0.46

The enrolled patients underwent a specific clinical evaluation including medical history, digital rectal examination, focused neurologic examination, I-PSS, urinalysis, serum prostate specific antigen (PSA) level, uroflowmetry, and measurement of postvoid residual volume with ultrasound bladder scan, transrectal ultrasonography, and urodynamic studies including the PFS.

Spec (examination) Gene_expression (focused) of I-PSS in bladder

10) Confidence 0.04 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2811296 Disease Relevance 0.79 Pain Relevance 0.09

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