INT148883

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.36
First Reported 2008
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 8
Total Number 27
Disease Relevance 24.82
Pain Relevance 1.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (HCRTR1) signal transducer activity (HCRTR1)
Anatomy Link Frequency
hypothalamus 3
T-cell 2
puncture 1
HCRTR1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Neuropeptide 43 100.00 Very High Very High Very High
Cannabinoid 2 99.60 Very High Very High Very High
Potency 3 98.38 Very High Very High Very High
agonist 21 95.94 Very High Very High Very High
antagonist 13 95.62 Very High Very High Very High
opioid receptor 19 93.52 High High
Neurotransmitter 8 85.84 High High
depression 30 85.72 High High
opiate 21 83.76 Quite High
Opioid 5 82.96 Quite High
Disease Link Frequency Relevance Heat
Sleep Disorders 1988 99.54 Very High Very High Very High
Idiopathic Hypersomnolence 503 99.48 Very High Very High Very High
Disease 246 99.14 Very High Very High Very High
Obesity 149 98.72 Very High Very High Very High
Lumbar Puncture Related Headaches 20 98.50 Very High Very High Very High
Hypersomnia 760 97.96 Very High Very High Very High
Apnoea 33 96.56 Very High Very High Very High
Disease Progression 61 96.44 Very High Very High Very High
Hallucination 112 94.00 High High
Dementia 5 93.00 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Briefly, patients' anti-hypocretin-1 IgG autoAbs were coated on Maxisorp plates (Nunc) at 2 µg/ml in 100 mM NaHCO3 buffer; sera (diluted 1?
Gene_expression (autoAbs) of hypocretin-1 IgG
1) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954157 Disease Relevance 0.09 Pain Relevance 0
In contrast, disease duration correlated positively with the IgA class of total and free hypocretin-1 autoAbs (r?
Gene_expression (class) of hypocretin associated with disease
2) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954157 Disease Relevance 1.71 Pain Relevance 0
The presence of IgG immune complexes with hypocretin-1 correlated positively with the frequency of cataplexy (r?
Gene_expression (presence) of hypocretin associated with sleep disorders
3) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954157 Disease Relevance 1.67 Pain Relevance 0
Unexpectedly, we found increased levels of hypocretin-1 total IgM autoAbs and anti-idiotypic IgM autoAbs in all three groups of patients and particularly significant in the HI group.
Gene_expression (autoAbs) of hypocretin associated with idiopathic hypersomnolence
4) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954157 Disease Relevance 0.78 Pain Relevance 0.13
Unexpectedly, we found increased levels of hypocretin-1 total IgM autoAbs and anti-idiotypic IgM autoAbs in all three groups of patients and particularly significant in the HI group.
Gene_expression (autoAbs) of hypocretin associated with idiopathic hypersomnolence
5) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954157 Disease Relevance 0.77 Pain Relevance 0.13
Disease duration correlated positively with levels of IgA hypocretin autoAbs, suggesting an increase of luminal antigenic stimulation to produce such autoAbs during disease progression that again may be triggered by yet unidentified molecular mimicry of microorganisms.
Gene_expression (autoAbs) of hypocretin associated with disease and disease progression
6) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954157 Disease Relevance 0.85 Pain Relevance 0
Increased levels of immune complexes of hypocretin-1 IgG autoAbs especially reported in NC may signify deficient hypocretin signalling as has been shown recently for ?
Gene_expression (autoAbs) of hypocretin-1 IgG associated with sleep disorders
7) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954157 Disease Relevance 0.68 Pain Relevance 0
0.016), or mean sleep latency with levels of immune complexes of hypocretin-1 IgA autoAbs (r?
Gene_expression (autoAbs) of hypocretin-1 IgA
8) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954157 Disease Relevance 1.62 Pain Relevance 0
Future studies should precise whether hypocretin-reactive autoAbs are involved in physiological regulation of hypocretin availability relevant to arousal and sleep/wakefulness



Spec (whether) Gene_expression (autoAbs) of hypocretin-reactive
9) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954157 Disease Relevance 0.84 Pain Relevance 0
Increased levels of immune complexes of hypocretin-1 IgG autoAbs especially reported in NC may signify deficient hypocretin signalling as has been shown recently for ?
Gene_expression (signalling) of hypocretin associated with sleep disorders
10) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954157 Disease Relevance 0.67 Pain Relevance 0
Significant correlations for ESS with levels of hypocretin-1 free IgG autoAbs in the NC group (r?
Gene_expression (levels) of hypocretin associated with sleep disorders
11) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954157 Disease Relevance 1.61 Pain Relevance 0
Future studies should precise whether hypocretin-reactive autoAbs are involved in physiological regulation of hypocretin availability relevant to arousal and sleep/wakefulness



Gene_expression (availability) of hypocretin
12) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954157 Disease Relevance 0.71 Pain Relevance 0
Hypocretin-1 (orexin A) and hypocretin-2 (orexin B) are two neuropeptides produced by the same precursor molecule and synthesized in neurons of the lateral hypothalamus [1], [2].
Gene_expression (produced) of hypocretin in hypothalamus associated with neuropeptide
13) Confidence 0.33 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954157 Disease Relevance 0.43 Pain Relevance 0.05
Disease duration correlated negatively with serum levels of hypocretin-1 IgG and IgM autoantibodies and with anti-idiotypic IgM autoantibodies.


Gene_expression (levels) of hypocretin-1 IgG associated with disease
14) Confidence 0.33 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2954157 Disease Relevance 1.46 Pain Relevance 0
Second, we did not assay serum levels of hypocretin to see their possible correlations with hypocretin autoAbs.
Gene_expression (levels) of hypocretin
15) Confidence 0.33 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954157 Disease Relevance 1.17 Pain Relevance 0
Hypocretin-1 (orexin A) and hypocretin-2 (orexin B) are two neuropeptides produced by the same precursor molecule and synthesized in neurons of the lateral hypothalamus [1], [2].
Gene_expression (synthesized) of hypocretin in hypothalamus associated with neuropeptide
16) Confidence 0.33 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954157 Disease Relevance 0.61 Pain Relevance 0.05
Before Bonferroni correction, levels of anti-idiotypic IgM autoAbs correlated negatively with CSF hypocretin-1 levels in all patients' groups (r?
Gene_expression (levels) of CSF hypocretin-1
17) Confidence 0.32 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954157 Disease Relevance 0.76 Pain Relevance 0
A lumbar puncture was performed in 35 patients (19 NC, 7 NWC, 9 HI) in order to measure the CSF hypocretin-1/orexin A levels.
Gene_expression (/) of CSF hypocretin-1 in puncture associated with idiopathic hypersomnolence, sleep disorders and lumbar puncture related headaches
18) Confidence 0.32 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954157 Disease Relevance 1.08 Pain Relevance 0
Hypocretin-1 (orexin A) and hypocretin-2 (orexin B) are two neuropeptides produced by the same precursor molecule and synthesized in neurons of the lateral hypothalamus [1], [2].
Gene_expression (produced) of Hypocretin in hypothalamus associated with neuropeptide
19) Confidence 0.28 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954157 Disease Relevance 0.43 Pain Relevance 0.05
Deficiency in hypocretin peptides production or defects in their receptors were found to cause narcolepsy-like symptoms in animals [3], [4].
Gene_expression (production) of hypocretin associated with hypersomnia
20) Confidence 0.28 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954157 Disease Relevance 0.79 Pain Relevance 0.05

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox