INT148885

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Context Info
Confidence 0.29
First Reported 2008
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 2
Total Number 5
Disease Relevance 3.41
Pain Relevance 0.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (HCRTR1) signal transducer activity (HCRTR1)
Anatomy Link Frequency
T-cell 1
HCRTR1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Neuropeptide 9 90.80 High High
opiate 4 64.56 Quite High
depression 4 60.96 Quite High
reflex sympathetic dystrophy 5 50.00 Quite Low
Inflammatory mediators 1 50.00 Quite Low
Central nervous system 1 5.00 Very Low Very Low Very Low
Neuropathic pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypersomnia 152 99.56 Very High Very High Very High
Sleep Disorders 348 99.12 Very High Very High Very High
Idiopathic Hypersomnolence 100 91.44 High High
Autoimmune Disease 8 91.12 High High
Dystonia 2 90.72 High High
Complex Regional Pain Syndromes 5 89.80 High High
Disease 36 76.60 Quite High
Depression 4 60.96 Quite High
INFLAMMATION 1 50.00 Quite Low
Disease Progression 12 48.24 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, our finding of elevated levels of anti-idiotypic autoAbs in patients with central hypersomnia may be biologically significant in controlling the peripheral hypocretin availability.
Regulation (controlling) of hypocretin associated with hypersomnia
1) Confidence 0.29 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954157 Disease Relevance 0.58 Pain Relevance 0.10
Because any autoAbs exist as a free fraction and as immune complexes, it is possible that relative amount of free and complexed autoAbs against hypocretin peptides may participate in the regulation of hypocretin availability and therefore can be associated with sleep/wake dysregulation.
Regulation (regulation) of hypocretin
2) Confidence 0.15 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954157 Disease Relevance 0.96 Pain Relevance 0.05
Future studies should precise whether hypocretin-reactive autoAbs are involved in physiological regulation of hypocretin availability relevant to arousal and sleep/wakefulness



Spec (whether) Regulation (regulation) of hypocretin
3) Confidence 0.15 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954157 Disease Relevance 0.71 Pain Relevance 0
However, the mechanism responsible for alteration of the hypocretin system in narcolepsy-cataplexy and its relevance to other central hypersomnias remain unknown.
Regulation (alteration) of hypocretin associated with hypersomnia and sleep disorders
4) Confidence 0.13 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2954157 Disease Relevance 0.97 Pain Relevance 0
We measured interleukin-1beta, interleukin-6, interferon-gamma inducible protein-10, RANTES (regulated upon activation, normal T-cell expressed and secreted), complement C3, mannose-binding lectin, complement C1q, soluble intercellular adhesion molecule-1, endothelin-1, nitric oxide, human lactoferrin, and hypocretin-1 levels in these samples.
Regulation (regulated) of hypocretin-1 in T-cell
5) Confidence 0.03 Published 2008 Journal Clin J Pain Section Body Doc Link 18180633 Disease Relevance 0.18 Pain Relevance 0

General Comments

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