INT148886

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Context Info
Confidence 0.23
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 5
Disease Relevance 3.42
Pain Relevance 0.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (HCRTR1) signal transducer activity (HCRTR1)
Anatomy Link Frequency
puncture 2
T-cell 2
HCRTR1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Neuropeptide 9 95.76 Very High Very High Very High
reflex sympathetic dystrophy 5 50.00 Quite Low
Inflammatory mediators 1 50.00 Quite Low
depression 4 5.00 Very Low Very Low Very Low
opiate 4 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
Neuropathic pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Sleep Disorders 348 99.84 Very High Very High Very High
Idiopathic Hypersomnolence 100 99.72 Very High Very High Very High
Lumbar Puncture Related Headaches 4 98.74 Very High Very High Very High
Hypersomnia 152 97.96 Very High Very High Very High
Dystonia 2 94.32 High High
Complex Regional Pain Syndromes 5 93.40 High High
Ehlers-danlos Syndrome 16 82.68 Quite High
Mental Disorders 8 80.52 Quite High
Overweight 4 70.32 Quite High
Apnoea 4 62.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Increased levels of immune complexes of hypocretin-1 IgG autoAbs especially reported in NC may signify deficient hypocretin signalling as has been shown recently for ?
Negative_regulation (deficient) of Gene_expression (signalling) of hypocretin associated with sleep disorders
1) Confidence 0.23 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954157 Disease Relevance 0.67 Pain Relevance 0
Increased levels of immune complexes of hypocretin-1 IgG autoAbs especially reported in NC may signify deficient hypocretin signalling as has been shown recently for ?
Negative_regulation (reported) of Gene_expression (autoAbs) of hypocretin-1 IgG associated with sleep disorders
2) Confidence 0.23 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954157 Disease Relevance 0.68 Pain Relevance 0
Deficiency in hypocretin peptides production or defects in their receptors were found to cause narcolepsy-like symptoms in animals [3], [4].
Negative_regulation (Deficiency) of Gene_expression (production) of hypocretin associated with hypersomnia
3) Confidence 0.20 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954157 Disease Relevance 0.79 Pain Relevance 0.05
A lumbar puncture was performed in 35 patients (19 NC, 7 NWC, 9 HI) in order to measure the CSF hypocretin-1/orexin A levels.
Negative_regulation (measure) of Gene_expression (/) of CSF hypocretin-1 in puncture associated with idiopathic hypersomnolence, sleep disorders and lumbar puncture related headaches
4) Confidence 0.20 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954157 Disease Relevance 1.08 Pain Relevance 0
We measured interleukin-1beta, interleukin-6, interferon-gamma inducible protein-10, RANTES (regulated upon activation, normal T-cell expressed and secreted), complement C3, mannose-binding lectin, complement C1q, soluble intercellular adhesion molecule-1, endothelin-1, nitric oxide, human lactoferrin, and hypocretin-1 levels in these samples.
Negative_regulation (measured) of Gene_expression (expressed) of hypocretin-1 in T-cell
5) Confidence 0.09 Published 2008 Journal Clin J Pain Section Body Doc Link 18180633 Disease Relevance 0.19 Pain Relevance 0

General Comments

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