INT148892

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Context Info
Confidence 0.37
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 13
Total Number 13
Disease Relevance 19.21
Pain Relevance 3.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (HPS1) cytoplasmic membrane-bounded vesicle (HPS1) lysosome (HPS1)
cytoplasm (HPS1)
Anatomy Link Frequency
blood 1
stem 1
respiratory 1
HPS1 (Homo sapiens)
Pain Link Frequency Relevance Heat
reflex sympathetic dystrophy 2 100.00 Very High Very High Very High
Crohn's disease 147 99.84 Very High Very High Very High
Infliximab 105 98.74 Very High Very High Very High
Inflammation 57 98.48 Very High Very High Very High
cva 9 94.16 High High
alcohol 65 93.04 High High
abdominal pain 9 90.92 High High
addiction 11 86.28 High High
Opioid 1 85.84 High High
corticosteroid 48 83.28 Quite High
Disease Link Frequency Relevance Heat
Hantavirus Infection 372 100.00 Very High Very High Very High
Complex Regional Pain Syndromes 2 100.00 Very High Very High Very High
Colitis 224 99.98 Very High Very High Very High
Disease 213 99.92 Very High Very High Very High
Enterocolitis 56 99.92 Very High Very High Very High
Syndrome 50 99.36 Very High Very High Very High
Adenomatous Polyps 1 99.32 Very High Very High Very High
Hyperplasia 15 98.86 Very High Very High Very High
INFLAMMATION 35 98.48 Very High Very High Very High
Respiratory Failure 10 98.12 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Without drawing causal conclusions however, it may be prudent to intervene with HPs who continue to smoke despite the obvious health risks.
HPs Binding (intervene) of
1) Confidence 0.37 Published 2008 Journal Subst Abuse Treat Prev Policy Section Body Doc Link PMC2265282 Disease Relevance 0.26 Pain Relevance 0.38
Previously published reports have indicated that medical treatment of granulomatous colitis associated with HPS has been unsuccessful.
HPS Binding (associated) of associated with colitis and hantavirus infection
2) Confidence 0.35 Published 2007 Journal J Med Case Reports Section Body Doc Link PMC2222675 Disease Relevance 1.62 Pain Relevance 0.28
An analysis of most reported cases, since Schinella et al. first reported granulomatous colitis in association with HPS (1980), suggests that the colitis of HPS is simply a reaction to the tissue deposition of ceroid [4].
HPS Binding (association) of associated with colitis and hantavirus infection
3) Confidence 0.35 Published 2007 Journal J Med Case Reports Section Body Doc Link PMC2222675 Disease Relevance 2.70 Pain Relevance 0.30
More research is needed to determine the cause of the granulomatous enterocolitis of HPS and also possible common genetic linkages with Crohn's disease.


HPS Binding (linkages) of associated with crohn's disease, enterocolitis, disease and hantavirus infection
4) Confidence 0.27 Published 2007 Journal J Med Case Reports Section Body Doc Link PMC2222675 Disease Relevance 1.56 Pain Relevance 0.34
In addition, the fact that infliximab results in a response in some of these patients suggests that HPS may be linked to Crohn's disease, or at least that TNF-a plays a pivotal role in both types of colitis.
HPS Binding (linked) of associated with colitis, crohn's disease, infliximab, disease and hantavirus infection
5) Confidence 0.27 Published 2007 Journal J Med Case Reports Section Body Doc Link PMC2222675 Disease Relevance 1.84 Pain Relevance 0.51
The granulomatous colitis associated with HPS usually manifests in the first and second decades and has been described as having a clinical presentation similar to chronic ulcerative colitis and pathologic findings consistent with Crohn's disease [3,4,8].
HPS Binding (associated) of associated with colitis, inflammatory bowel disease, crohn's disease, disease and hantavirus infection
6) Confidence 0.26 Published 2007 Journal J Med Case Reports Section Body Doc Link PMC2222675 Disease Relevance 2.07 Pain Relevance 0.26
HPS has been associated with gastrointestinal (GI) complications related to chronic granulomatous colitis with pathologic features suggestive of Crohn's disease.
HPS Binding (associated) of associated with colitis, crohn's disease, disease and hantavirus infection
7) Confidence 0.26 Published 2007 Journal J Med Case Reports Section Abstract Doc Link PMC2222675 Disease Relevance 1.10 Pain Relevance 0.30
It is still unclear if the granulomatous colitis associated with HPS is part of the syndrome or if it represents an independent but associated process, such as Crohn's disease.
HPS Binding (associated) of associated with colitis, crohn's disease, syndrome, disease and hantavirus infection
8) Confidence 0.26 Published 2007 Journal J Med Case Reports Section Body Doc Link PMC2222675 Disease Relevance 1.69 Pain Relevance 0.62
Smokers are more likely to present with hyperplastic polyps, even in asymptomatic individuals [34], with the most significant association between smokers and serrated neoplasia in the population having both hyperplastic and adenomatous polyps [35–37], a phenotype shared with individuals with HPS.
HPS Binding (individuals) of associated with nicotine addiction, cancer, polyps, hantavirus infection, adenomatous polyps and hyperplasia
9) Confidence 0.22 Published 2010 Journal Int J Colorectal Dis Section Body Doc Link PMC2862176 Disease Relevance 2.51 Pain Relevance 0
The 800A and 641T minor alleles located within the structural domain of the val158 region did not significantly alter this local stem-loop structure or nearby structural domains associated with the APS and HPS haplotypes, respectively.
HPS Binding (associated) of in stem associated with hantavirus infection
10) Confidence 0.22 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2664927 Disease Relevance 0.71 Pain Relevance 0.05
Some clinicians associated with HPS altered their treatment patterns in response and it was thought that this may have diluted the size of the effect of the trial interventions in HPS.
HPS Binding (associated) of associated with hantavirus infection
11) Confidence 0.17 Published 2006 Journal Trials Section Body Doc Link PMC1781076 Disease Relevance 0.44 Pain Relevance 0
Due to the severe increase in vascular permeability associated with HPS, disease progresses rapidly (within hours) to respiratory failure, shock, ARDS, coagulopathy, and arrhythmias [104,105].
HPS Binding (associated) of in respiratory associated with coagulation disorder, shock, respiratory failure, adult respiratory distress syndrome, disease and hantavirus infection
12) Confidence 0.10 Published 2008 Journal Crit Care Section Body Doc Link PMC2575602 Disease Relevance 2.34 Pain Relevance 0.09
BACKGROUND: In complex regional pain syndrome type 1 (CRPS1) vascular changes occur from the initial, inflammatory event onto the trophic signs during chronicity of the disease, resulting in blood flow disturbances and marked temperature changes.
complex regional pain syndrome type 1 Binding (BACKGROUND) of in blood associated with complex regional pain syndromes, inflammation, reflex sympathetic dystrophy and disease
13) Confidence 0.05 Published 2008 Journal Clin J Pain Section Abstract Doc Link 18180642 Disease Relevance 0.37 Pain Relevance 0.22

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