INT148898

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Context Info
Confidence 0.54
First Reported 2006
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 1.13
Pain Relevance 0.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Nr4a2) DNA binding (Nr4a2) response to stress (Nr4a2)
cytoplasm (Nr4a2)
Anatomy Link Frequency
juvenile 2
Nr4a2 (Mus musculus)
Pain Link Frequency Relevance Heat
Neurotransmitter 5 97.48 Very High Very High Very High
fluoxetine 2 88.08 High High
midbrain 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Aggression 6 99.26 Very High Very High Very High
Neurodegenerative Disease 8 98.00 Very High Very High Very High
Cognitive Disorder 2 92.60 High High
Apoptosis 6 73.88 Quite High
Disease 2 70.76 Quite High
Reproductive System Disorders 1 12.00 Low Low
Neuroblastoma 9 5.00 Very Low Very Low Very Low
Drug Induced Neurotoxicity 7 5.00 Very Low Very Low Very Low
Death 5 5.00 Very Low Very Low Very Low
Toxicity 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These findings suggest that communication in juvenile is important in the survival and differentiation of newly divided cells, which may be associated with memory and aggression, and raise the possibility that the reduced expression of Nurr1 and/or Npas4 may contribute to the impairment of neurogenesis and memory and aggression induced by SI.
Negative_regulation (reduced) of Gene_expression (expression) of Nurr1 in juvenile associated with aggression and neurodegenerative disease
1) Confidence 0.54 Published 2008 Journal J. Neurochem. Section Abstract Doc Link 18182044 Disease Relevance 0.65 Pain Relevance 0.08
We finally found that SI reduced the expression of development-related genes Nurr1 and Npas4.
Negative_regulation (reduced) of Gene_expression (expression) of Nurr1
2) Confidence 0.40 Published 2008 Journal J. Neurochem. Section Abstract Doc Link 18182044 Disease Relevance 0.41 Pain Relevance 0.09
We assessed the expression of tyrosine hydroxylase (TH) and Nurr-1.
Negative_regulation (assessed) of Gene_expression (expression) of Nurr-1
3) Confidence 0.03 Published 2006 Journal Environ Health Section Body Doc Link PMC1570454 Disease Relevance 0.07 Pain Relevance 0.10

General Comments

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