INT148901

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Context Info
Confidence 0.39
First Reported 2008
Last Reported 2009
Negated 0
Speculated 1
Reported most in Body
Documents 2
Total Number 6
Disease Relevance 3.65
Pain Relevance 4.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Sort1) endosome (Sort1) transport (Sort1)
Golgi apparatus (Sort1) endoplasmic reticulum (Sort1) intracellular (Sort1)
Anatomy Link Frequency
spinal 1
Sort1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 235 99.84 Very High Very High Very High
Analgesic 69 99.24 Very High Very High Very High
Pain 242 98.28 Very High Very High Very High
antinociception 41 97.82 Very High Very High Very High
Antinociceptive 52 97.44 Very High Very High Very High
Inflammation 70 96.96 Very High Very High Very High
Eae 25 94.08 High High
Spontaneous pain 10 94.00 High High
Neuropeptide 1 91.72 High High
Pain score 10 89.80 High High
Disease Link Frequency Relevance Heat
Nociception 226 99.40 Very High Very High Very High
Pain 310 98.28 Very High Very High Very High
Low Back Pain 11 98.16 Very High Very High Very High
INFLAMMATION 75 96.96 Very High Very High Very High
Inflammatory Pain 20 94.08 High High
Injury 20 93.24 High High
Ganglion Cysts 26 70.48 Quite High
Hyperalgesia 5 69.20 Quite High
Urological Neuroanatomy 15 69.12 Quite High
Neuropathic Pain 10 67.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Indeed, both JMV-431 and levocabastine had higher nociceptive scores than did NT69L (which binds to both NTS1 and NTS2) during the early phase 2 (21–39 min), while all drugs were efficient in reducing pain during the late phase 2 (40–60 min) (Fig. 2).
NTS1 Binding (binds) of associated with nociception and pain
1) Confidence 0.39 Published 2009 Journal Mol Pain Section Body Doc Link PMC2714839 Disease Relevance 0.94 Pain Relevance 0.78
In addition, the NT(8–13) analog NT69L, which contains a L-neo-tryptophan amino acid, and exhibits high affinity for both rat (IC50 = 2.2 ± 0.5 nM) and human NTS1 [49] also appeared as a ligand with a good affinity for the rat NTS2 (IC50 = 3.7 ± 0.4 nM).
NTS1 Spec (appeared) Binding (affinity) of
2) Confidence 0.30 Published 2009 Journal Mol Pain Section Body Doc Link PMC2714839 Disease Relevance 0.12 Pain Relevance 0.15
The involvement of additional receptors is indeed suggested by the finding that the reversal by SR48692 of the antinociception produced by PD149163 was more complete than of that induced by NT69L, a peptidase resistant NT analog which binds to both NTS1 and NTS2 receptors with high affinity, but in a non-selective manner [37].
NTS1 Binding (binds) of associated with antinociception
3) Confidence 0.29 Published 2009 Journal Mol Pain Section Body Doc Link PMC2714839 Disease Relevance 0.84 Pain Relevance 1.07
We first demonstrated that spinally administered NT and NT69L agonists, which bind to both NTS1 and NTS2 receptors, significantly reduced pain-evoked responses during the inflammatory phase of the formalin test.
NTS1 Binding (bind) of associated with pain, inflammation and agonist
4) Confidence 0.29 Published 2009 Journal Mol Pain Section Abstract Doc Link PMC2714839 Disease Relevance 0.52 Pain Relevance 0.77
Alternatively, the cumulative effects of NT69L (which binds to both NTS1 and NTS2) on lifting and licking/biting behaviors may reveal that NTS1 receptor activation modulates supraspinal nociceptive networks following formalin-induced tissue injury.
NTS1 Binding (binds) of associated with nociception and injury
5) Confidence 0.29 Published 2009 Journal Mol Pain Section Body Doc Link PMC2714839 Disease Relevance 0.83 Pain Relevance 0.82
Although NTS2 receptors play an important role in modulating the activity of spinal neurons, we have recently implicated NTS1 receptors in NT's analgesic effects in acute spinal pain paradigms.
NTS1 Binding (implicated) of in spinal associated with low back pain, pain and analgesic
6) Confidence 0.22 Published 2008 Journal J. Neurochem. Section Abstract Doc Link 18182046 Disease Relevance 0.40 Pain Relevance 0.73

General Comments

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