INT14891

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.70
First Reported 1989
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 10
Total Number 12
Disease Relevance 5.37
Pain Relevance 1.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (ACHE) extracellular space (ACHE) extracellular region (ACHE)
cell adhesion (ACHE) Golgi apparatus (ACHE) plasma membrane (ACHE)
Anatomy Link Frequency
neurons 1
brain 1
ganglion cells 1
Respiratory 1
ACHE (Homo sapiens)
Pain Link Frequency Relevance Heat
positron emission tomography 9 99.96 Very High Very High Very High
Neurotransmitter 7 98.36 Very High Very High Very High
antagonist 10 98.32 Very High Very High Very High
palliative 1 97.16 Very High Very High Very High
substance P 5 97.04 Very High Very High Very High
Endogenous opioid 1 96.98 Very High Very High Very High
Enkephalin 9 95.76 Very High Very High Very High
imagery 6 85.28 High High
depression 2 84.04 Quite High
Opioid 3 76.16 Quite High
Disease Link Frequency Relevance Heat
Disease 259 99.80 Very High Very High Very High
Ganglion Cysts 3 98.60 Very High Very High Very High
Poisoning 85 98.16 Very High Very High Very High
Toxicity 12 96.56 Very High Very High Very High
Aging 12 92.32 High High
Cognitive Disorder 67 91.40 High High
Respiratory Failure 8 89.24 High High
Dementia 34 87.08 High High
Depression 2 84.04 Quite High
Appetite Loss 4 83.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Short endorphins were noncompetitive activators of acetylcholinesterase.
Positive_regulation (activators) of acetylcholinesterase
1) Confidence 0.70 Published 1989 Journal Biull Eksp Biol Med Section Abstract Doc Link 2597760 Disease Relevance 0 Pain Relevance 0.32
Treatment includes resuscitation of patients and giving oxygen, a muscarinic antagonist (usually atropine), fluids, and an acetylcholinesterase reactivator (an oxime that reactivates acetylcholinesterase by removal of the phosphate group) (panel 3).35 Respiratory support is given as necessary.
Positive_regulation (reactivates) of acetylcholinesterase in Respiratory associated with antagonist
2) Confidence 0.63 Published 2008 Journal Lancet Section Body Doc Link PMC2493390 Disease Relevance 0.14 Pain Relevance 0.05
Increase in amount of these positive acetylcholinesterase neurons was demonstrated till term.
Positive_regulation (Increase) of acetylcholinesterase in neurons
3) Confidence 0.50 Published 1990 Journal Neuroscience Section Abstract Doc Link 1708469 Disease Relevance 0 Pain Relevance 0.50
Oximes, such as pralidoxime, can reactivate acetylcholinesterase but the ability to reverse acetylcholinesterase (AChE) inhibition with oximes varies with the type of pesticide ingested and time to treatment as both these factors affect the rate of enzyme ageing [8,9].
Positive_regulation (reactivate) of acetylcholinesterase associated with aging
4) Confidence 0.50 Published 2009 Journal Trials Section Body Doc Link PMC2743678 Disease Relevance 0.78 Pain Relevance 0.04
Acetylcholinesterase decreased earlier and more intensely than cholinesterase, with the suggestion of an initial increase of acetylcholinesterase activity in newly exposed, workers.
Positive_regulation (increase) of acetylcholinesterase
5) Confidence 0.49 Published 1991 Journal J. Toxicol. Clin. Toxicol. Section Abstract Doc Link 2005669 Disease Relevance 0.09 Pain Relevance 0
Exposure to large doses of organophosphate pesticides is required for significant AChE inhibition to occur, and therefore, it is more appropriately used as an indicator of toxicity at high exposure levels rather than low exposure levels (He 1999).
Positive_regulation (required) of AChE associated with toxicity
6) Confidence 0.48 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1480483 Disease Relevance 0.18 Pain Relevance 0.04
It is unclear whether the palliative effects of tetrahydroaminoacridine (THA) (tacrine, Cognex) on the clinical symptoms of patients affected by Alzheimer's disease (AD) are the result of its inhibitory activity on acetylcholinesterase or on other complex sites of action.
Spec (whether) Positive_regulation (result) of acetylcholinesterase associated with disease and palliative
7) Confidence 0.46 Published 1999 Journal Eur. J. Neurol. Section Abstract Doc Link 10210906 Disease Relevance 0.20 Pain Relevance 0.23
A biopsy was considered to be positive when the acetylcholinesterase activity was elevated in combination with an absence of ganglion cells.
Positive_regulation (elevated) of acetylcholinesterase in ganglion cells associated with ganglion cysts
8) Confidence 0.45 Published 2007 Journal BMC Pediatr Section Body Doc Link PMC1790893 Disease Relevance 0.50 Pain Relevance 0
The morbidity and mortality with organophosphate poisoning is relatively high despite the use of atropine as specific antidotal therapy and oximes to reactivate acetylcholinesterase.
Positive_regulation (reactivate) of acetylcholinesterase associated with poisoning
9) Confidence 0.40 Published 2008 Journal Anaesth Intensive Care Section Abstract Doc Link 18564794 Disease Relevance 0.54 Pain Relevance 0.12
A positron emission tomography (PET) evaluated acetylcholinesterase (AChE) activity in 14 individuals with AD before and after treatment with donepezil [14].
Positive_regulation (evaluated) of acetylcholinesterase associated with positron emission tomography and disease
10) Confidence 0.34 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2866463 Disease Relevance 1.37 Pain Relevance 0.10
A positron emission tomography (PET) evaluated acetylcholinesterase (AChE) activity in 14 individuals with AD before and after treatment with donepezil [14].
Positive_regulation (evaluated) of AChE associated with positron emission tomography and disease
11) Confidence 0.29 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2866463 Disease Relevance 1.37 Pain Relevance 0.10
The animal experimental studies indicated that exposure to EMF of the microwave frequency activates the endogenous opioid system in the brain, while the studies of the brain neurotransmitter activity have not produced univocal results, some of them showed decline, others increase in acetylcholinesterase activity.
Positive_regulation (increase) of acetylcholinesterase in brain associated with neurotransmitter and endogenous opioid
12) Confidence 0.18 Published 2001 Journal Med Pr Section Abstract Doc Link 11761657 Disease Relevance 0.21 Pain Relevance 0.15

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox