INT148917

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Context Info
Confidence 0.50
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 0.88
Pain Relevance 1.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Bdkrb1) signal transducer activity (Bdkrb1)
Anatomy Link Frequency
spinal cord 2
peripheral nerve 2
Bdkrb1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
B1 receptor 192 100.00 Very High Very High Very High
b2 receptor 1 100.00 Very High Very High Very High
Peripheral nerve injury 3 98.84 Very High Very High Very High
antagonist 35 97.48 Very High Very High Very High
agonist 26 92.08 High High
Spinal cord 43 90.08 High High
bradykinin 39 89.84 High High
cytokine 10 89.28 High High
Inflammation 13 88.88 High High
Dorsal horn 5 78.48 Quite High
Disease Link Frequency Relevance Heat
Nervous System Injury 6 98.40 Very High Very High Very High
INFLAMMATION 17 88.88 High High
Pain 20 75.36 Quite High
Neuropathic Pain 98 75.00 Quite High
Diabetes Mellitus 85 67.24 Quite High
Stress 36 66.24 Quite High
Hyperglycemia 9 61.40 Quite High
Pressure And Volume Under Development 19 50.00 Quite Low
Insulin Resistance 14 50.00 Quite Low
Ganglion Cysts 1 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The enhanced mRNA expression (B1R, IL-1beta, TNF-alpha, TRPV1) and Iba-1 immunoreactivity in the STZ spinal cord were normalized by fluorocitrate or minocycline, yet B1R binding sites were reduced by 38%.
Positive_regulation (enhanced) of Transcription (expression) of B1R in spinal cord
1) Confidence 0.50 Published 2010 Journal J Neuroinflammation Section Body Doc Link 20587056 Disease Relevance 0.16 Pain Relevance 0
Kinin B1 and B2 receptor (R) gene expression (mRNA) is increased in the sensory system after peripheral nerve injury.
Positive_regulation (increased) of Transcription (expression) of Kinin B1 in peripheral nerve associated with nervous system injury, b2 receptor and peripheral nerve injury
2) Confidence 0.49 Published 2008 Journal Int. Immunopharmacol. Section Abstract Doc Link 18182225 Disease Relevance 0.25 Pain Relevance 0.40
To further substantiate the contribution of B1R in the production of O2•?
Positive_regulation (substantiate) of Transcription (contribution) of B1R associated with b1 receptor
3) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935380 Disease Relevance 0 Pain Relevance 0.53
However, the increased mRNA level of TRPV1 in STZ was much less striking (3-fold) than that of B1R (27-fold), IL-1?
Positive_regulation (increased) of Transcription (level) of B1R associated with b1 receptor
4) Confidence 0.49 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2913947 Disease Relevance 0.48 Pain Relevance 0.89

General Comments

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