INT148937

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Context Info
Confidence 0.13
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 2.25
Pain Relevance 1.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Csk) plasma membrane (Csk) cytoplasm (Csk)
Anatomy Link Frequency
dorsal horn 1
Csk (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dorsal horn 6 98.02 Very High Very High Very High
Pain 14 97.68 Very High Very High Very High
intrathecal 1 92.56 High High
Brush evoked pain 9 83.60 Quite High
Neuropathic pain 4 81.60 Quite High
Taxol 30 76.64 Quite High
vincristine 2 75.84 Quite High
allodynia 1 73.52 Quite High
Spinal cord 1 71.36 Quite High
Stimulus evoked pain 1 63.20 Quite High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 9 98.34 Very High Very High Very High
Pain 13 97.68 Very High Very High Very High
Cancer 3 85.36 High High
Neuropathic Pain 15 83.60 Quite High
Nociception 14 81.80 Quite High
Nervous System Injury 1 69.76 Quite High
Congenital Anomalies 1 67.12 Quite High
Hypersensitivity 1 63.20 Quite High
Non-diabetic Peripheral Neuropathy 1 58.44 Quite High
Hyperalgesia 4 20.08 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, in the dorsal horn of STZ diabetic rats, extracellular signal-regulated protein kinase (ERK) and an upstream kinase, Src-family kinase (SFK), both of which are implicated in microglial functions, were activated exclusively in microglia.
Positive_regulation (activated) of Src-family kinase in dorsal horn associated with diabetes mellitus and dorsal horn
1) Confidence 0.13 Published 2008 Journal Glia Section Abstract Doc Link 18186080 Disease Relevance 1.53 Pain Relevance 1.10
Thus membrane-associated tubulin-TRPV4 complex seems to be important for stimuli that activate Src-tyrosine kinase.


Positive_regulation (activate) of Src-tyrosine kinase
2) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2906515 Disease Relevance 0.72 Pain Relevance 0.53

General Comments

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