INT148944

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Context Info
Confidence 0.59
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.07
Pain Relevance 1.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (UGT1A1) endoplasmic reticulum (UGT1A1) enzyme binding (UGT1A1)
Anatomy Link Frequency
liver 1
intestine 1
UGT1A1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Morphine 31 95.24 Very High Very High Very High
Opioid 1 68.40 Quite High
Inflammation 2 65.40 Quite High
Paracetamol 2 64.12 Quite High
Bile 9 56.92 Quite High
Analgesic 2 46.12 Quite Low
agonist 13 9.20 Low Low
Kinase C 4 5.00 Very Low Very Low Very Low
dexamethasone 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 2 65.40 Quite High
Hyperbilirubinemia 1 22.40 Low Low
Syndrome 2 17.52 Low Low
Van Bogaert's Disease 7 5.00 Very Low Very Low Very Low
Sprains And Strains 2 5.00 Very Low Very Low Very Low
Toxicity 2 5.00 Very Low Very Low Very Low
Targeted Disruption 2 5.00 Very Low Very Low Very Low
Gallstones 2 5.00 Very Low Very Low Very Low
Insulin Resistance 1 5.00 Very Low Very Low Very Low
Osteogenic Sarcomas 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, to estimate the contribution of these UGT isozymes in M6G formation in vivo, the expression levels of UGT1A1 and 1A8 mRNA in human liver and intestine were determined by reverse transcription real-time polymerase chain reaction.
Transcription (contribution) of UGT1A1 in intestine
1) Confidence 0.59 Published 2008 Journal Drug Metab. Dispos. Section Abstract Doc Link 18187562 Disease Relevance 0 Pain Relevance 0.81
Each of nine functional UGT1A proteins is produced as a result of transcription initiation at a particular promoter, which results in the transcription and splicing of a unique exon 1 sequence to a cassette of common exons (exons 2–5) that share the same 3?
Transcription (transcription) of UGT1A
2) Confidence 0.37 Published 2009 Journal PPAR Research Section Body Doc Link PMC2724710 Disease Relevance 0.07 Pain Relevance 0.22
Furthermore, to estimate the contribution of these UGT isozymes in M6G formation in vivo, the expression levels of UGT1A1 and 1A8 mRNA in human liver and intestine were determined by reverse transcription real-time polymerase chain reaction.
Transcription (contribution) of UGT1A1 in liver
3) Confidence 0.20 Published 2008 Journal Drug Metab. Dispos. Section Abstract Doc Link 18187562 Disease Relevance 0 Pain Relevance 0.81

General Comments

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