INT148946

Context Info Confidence 0.02 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Abstract Documents 2 Total Number 2 Disease Relevance 0 Pain Relevance 1.21

unfolded protein binding (CCT6A) protein folding (CCT6A) cytosol (CCT6A) cytoplasm (CCT6A)

CCT6A (Homo sapiens)

Pain Link Frequency Relevance Heat Morphine 15 100.00 addiction 4 100.00 Analgesic 1 63.92 withdrawal 1 5.00 Pain 1 5.00

Disease Link Frequency Relevance Heat Anxiety Disorder 4 40.80 Confusion 3 16.32 Intellectual Impairment 13 5.00 Mental Disorders 8 5.00 Emergencies 5 5.00 Injury 3 5.00 Pain 1 5.00 Aggression 1 5.00 Death 1 5.00 Shock 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The field possesses a rich potential to discover the negative consequences of verbal abuse, deprivation, dependence, and injustice.

Negative_regulation (deprivation) of dependence associated with addiction

1) Confidence 0.02 Published 2008 Journal Philos Ethics Humanit Med Section Body Doc Link PMC2248202 Disease Relevance 0 Pain Relevance 0.05

However, as the morphine concentration approached 100 muM, morphine-6-glucuronidation activity gradually decreased, and the kinetics closely resembled substrate inhibition Michaelis-Menten kinetic behavior.

Negative_regulation (decreased) of morphine-6-glucuronidation associated with morphine

2) Confidence 0.02 Published 2008 Journal Drug Metab. Dispos. Section Abstract Doc Link 18187562 Disease Relevance 0 Pain Relevance 1.16

General Comments

This test has worked.