INT148968

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Context Info
Confidence 0.56
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 29
Total Number 32
Disease Relevance 11.90
Pain Relevance 5.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Gpbar1) plasma membrane (Gpbar1) signal transducer activity (Gpbar1)
Anatomy Link Frequency
macrophages 6
central nervous system 2
microglia 2
plasma 1
bone marrow 1
Gpbar1 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 250 100.00 Very High Very High Very High
dorsal root ganglion 24 99.80 Very High Very High Very High
Serotonin 25 99.00 Very High Very High Very High
Inflammation 257 98.52 Very High Very High Very High
cytokine 46 98.18 Very High Very High Very High
IPN 68 97.88 Very High Very High Very High
Central nervous system 18 97.88 Very High Very High Very High
qutenza 88 97.12 Very High Very High Very High
Arthritis 56 94.76 High High
Inflammatory stimuli 44 94.04 High High
Disease Link Frequency Relevance Heat
Ganglion Cysts 28 99.80 Very High Very High Very High
Disease 60 98.68 Very High Very High Very High
INFLAMMATION 380 98.52 Very High Very High Very High
Diabetes Mellitus 56 98.32 Very High Very High Very High
Inflammatory Pain 68 97.88 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 301 96.96 Very High Very High Very High
Repression 12 95.96 Very High Very High Very High
Bordatella Infection 15 95.60 Very High Very High Very High
Hyperplasia 9 95.32 Very High Very High Very High
Arthritis 59 94.76 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Dorsal root ganglion (DRG) neurons express mRNAs for numerous two-pore domain K(+) (K(2P)) channels and G-protein coupled receptors (GPCR).
Gene_expression (express) of GPCR in pore associated with ganglion cysts and dorsal root ganglion
1) Confidence 0.56 Published 2008 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 18190784 Disease Relevance 0.51 Pain Relevance 0.57
LPS-regulated GPCR expression in mouse macrophages
Gene_expression (expression) of GPCR in macrophages
2) Confidence 0.27 Published 2008 Journal Immunome Res Section Body Doc Link PMC2394514 Disease Relevance 0.05 Pain Relevance 0
Differential GPCR expression in distinct macrophage populations
Gene_expression (expression) of GPCR in macrophage
3) Confidence 0.27 Published 2008 Journal Immunome Res Section Body Doc Link PMC2394514 Disease Relevance 0.18 Pain Relevance 0.09
We then compared the GPCR expression profiles of BMM and TEPM to the remaining panel of cell types, and in doing so, identified 67 GPCRs that were detectably expressed either constitutively or in an LPS-induced manner in these primary macrophage populations [see additional file 1].
Gene_expression (expression) of GPCR in TEPM
4) Confidence 0.27 Published 2008 Journal Immunome Res Section Body Doc Link PMC2394514 Disease Relevance 0.17 Pain Relevance 0.05
Figure 3 highlights two examples of regulated GPCR expression: mRNA expression of Gpr84 was induced 10-fold by LPS (6 h) in BMM and 48-fold by LPS (7 h) in TEPM (Figure 3a), whilst P2ry1 was repressed 7-fold by LPS (6 h) in BMM and 18-fold by LPS (7 h) in TEPM (Figure 3b).
Gene_expression (expression) of GPCR
5) Confidence 0.27 Published 2008 Journal Immunome Res Section Body Doc Link PMC2394514 Disease Relevance 0.10 Pain Relevance 0
The 5-HT2C subtype of the serotonin receptor family is a G-protein coupled receptor (GPCR) that is broadly expressed in the brain and is proposed to mediate many of the central nervous system actions of serotonin, including those underlying the therapeutic benefit of SSRI treatment in OCD [15].
Gene_expression (expressed) of GPCR in central nervous system associated with anxiety disorder, central nervous system, ssri and serotonin
6) Confidence 0.26 Published 2008 Journal Current Chemical Genomics Section Body Doc Link PMC2746669 Disease Relevance 0.93 Pain Relevance 0.24
It is important to note, that cytokine production in this experiment was not induced by external stimuli, specifically targeting GPCR receptors and PI3K?
Gene_expression (receptors) of GPCR in external associated with cytokine
7) Confidence 0.25 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2867834 Disease Relevance 0.68 Pain Relevance 0.29
Constitutive GPCR expression in mouse macrophages
Gene_expression (expression) of GPCR in macrophages
8) Confidence 0.24 Published 2008 Journal Immunome Res Section Body Doc Link PMC2394514 Disease Relevance 0.41 Pain Relevance 0.16
The 5-HT2C subtype of the serotonin receptor family is a G-protein coupled receptor (GPCR) that is broadly expressed in the brain and is proposed to mediate many of the central nervous system actions of serotonin, including those underlying the therapeutic benefit of SSRI treatment in OCD [15].
Gene_expression (expressed) of GPCR in central nervous system associated with anxiety disorder, central nervous system, ssri and serotonin
9) Confidence 0.22 Published 2008 Journal Current Chemical Genomics Section Body Doc Link PMC2746669 Disease Relevance 0.93 Pain Relevance 0.24
The GPCR repertoire expressed by bone marrow-derived macrophages and thioglycollate-elicited peritoneal macrophages had some commonality, but there were also several GPCRs preferentially expressed by either cell population.


Gene_expression (expressed) of GPCR in bone marrow
10) Confidence 0.21 Published 2008 Journal Immunome Res Section Abstract Doc Link PMC2394514 Disease Relevance 0.15 Pain Relevance 0.11
In this study we performed a systematic micro-array analysis of GPCR expression in primary mouse macrophages to identify family members that are either enriched in macrophages compared to a panel of other cell types, or are regulated by an inflammatory stimulus, the bacterial product lipopolysaccharide (LPS).


Gene_expression (expression) of GPCR in macrophages associated with inflammatory stimuli
11) Confidence 0.21 Published 2008 Journal Immunome Res Section Abstract Doc Link PMC2394514 Disease Relevance 0.19 Pain Relevance 0.10
In this study we performed a systematic micro-array analysis of GPCR expression in primary mouse macrophages and identified family members that are either enriched in macrophages compared to a panel of other cell types, or are regulated by the pro-inflammatory stimulus, bacterial LPS.
Gene_expression (expression) of GPCR in macrophages associated with inflammatory stimuli
12) Confidence 0.21 Published 2008 Journal Immunome Res Section Body Doc Link PMC2394514 Disease Relevance 0.40 Pain Relevance 0.16
Gpr84 is an orphan GPCR that was strikingly restricted to BMM and microglia in an unstimulated state (Table 2, Figure 1c) and was strongly up-regulated by LPS in both BMM and TEPM (Figure 3a, Table 3).
Gene_expression (was) of GPCR in microglia
13) Confidence 0.20 Published 2008 Journal Immunome Res Section Body Doc Link PMC2394514 Disease Relevance 0.43 Pain Relevance 0.08
Gpr84 is an orphan GPCR that was strikingly restricted to BMM and microglia in an unstimulated state (Table 2, Figure 1c) and was strongly up-regulated by LPS in both BMM and TEPM (Figure 3a, Table 3).
Gene_expression (restricted) of GPCR in microglia
14) Confidence 0.20 Published 2008 Journal Immunome Res Section Body Doc Link PMC2394514 Disease Relevance 0.42 Pain Relevance 0.08
In particular, the expression of TDAG8, one proton-sensing GPCR, was increased 24 hours after CFA injection because of increased number of DRG neurons expressing TDAG8.
Gene_expression (expression) of GPCR in neurons
15) Confidence 0.18 Published 2009 Journal Mol Pain Section Abstract Doc Link PMC2716309 Disease Relevance 1.19 Pain Relevance 1.00
Differential expression of proton-sensing GPCR genes after induction of peripheral inflammation
Gene_expression (expression) of GPCR associated with inflammation
16) Confidence 0.18 Published 2009 Journal Mol Pain Section Body Doc Link PMC2716309 Disease Relevance 1.39 Pain Relevance 1.47
GPR40 is a Gq-coupled family A GPCR specifically expressed in the pancreatic ?
Gene_expression (expressed) of GPCR
17) Confidence 0.16 Published 2008 Journal Diabetes Section Body Doc Link PMC2494688 Disease Relevance 0.13 Pain Relevance 0.07
GPR40 is a Gq-coupled, family A GPCR that is highly expressed in ?
Gene_expression (expressed) of GPCR
18) Confidence 0.14 Published 2008 Journal Diabetes Section Body Doc Link PMC2494688 Disease Relevance 0.10 Pain Relevance 0.09
Higher magnification analysis of these cells suggested that, as expected for a GPCR, GPR17 was selectively expressed in the plasma-membrane of NeuN+ neurons (Figure 2D, 2D?
Gene_expression (expressed) of GPCR in plasma
19) Confidence 0.14 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2570486 Disease Relevance 0 Pain Relevance 0.04
The antidiuretic effect of vasopressin is achieved through the GPCR member, V2 receptor (V2R), which is expressed at the basolateral side of the tubules and the collecting ducts of the kidney (Lolait et al. 1992; Knepper, 1997; Robben et al. 2006).
Gene_expression (expressed) of GPCR member in kidney
20) Confidence 0.13 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733102 Disease Relevance 0 Pain Relevance 0

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