INT148980

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Context Info
Confidence 0.49
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.08
Pain Relevance 0.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (PER1) protein binding transcription factor activity (PER1) cytoplasm (PER1)
signal transducer activity (PER1)
PER1 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 1 97.32 Very High Very High Very High
sSRI 1 97.20 Very High Very High Very High
fluoxetine 4 94.08 High High
Serotonin 3 85.36 High High
Disease Link Frequency Relevance Heat
Affective Disorder 1 79.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In nocturnal rodents, injections during the subjective day of the 5-HT1A/7 receptor agonist 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT) or its positive enantiomer, induce behavioral phase-advances in correlation with decreased expression of two clock genes, Per1/2.
Negative_regulation (decreased) of Gene_expression (expression) of Per1 associated with agonist
1) Confidence 0.49 Published 2008 Journal Exp. Neurol. Section Abstract Doc Link 18190911 Disease Relevance 0.08 Pain Relevance 0.30

General Comments

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