INT148984

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.48
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 5.29
Pain Relevance 0.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (BAX) cytosol (BAX) mitochondrion (BAX)
endoplasmic reticulum (BAX) nucleus (BAX) cytoplasm (BAX)
Anatomy Link Frequency
B-cell 2
MCF-7 2
BAX (Homo sapiens)
Pain Link Frequency Relevance Heat
diclofenac 11 98.98 Very High Very High Very High
antagonist 9 97.16 Very High Very High Very High
COX-2 inhibitor 1 89.12 High High
cINOD 14 75.32 Quite High
Inflammation 10 50.00 Quite Low
cytokine 10 45.80 Quite Low
imagery 2 40.36 Quite Low
cOX1 1 25.00 Low Low
metalloproteinase 14 5.00 Very Low Very Low Very Low
addiction 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 171 100.00 Very High Very High Very High
Lymphatic System Cancer 1 99.36 Very High Very High Very High
Death 66 98.24 Very High Very High Very High
Injury 6 97.48 Very High Very High Very High
Toxicity 5 94.80 High High
Shock 9 91.84 High High
Breast Cancer 28 91.48 High High
Cancer 146 80.28 Quite High
Necrosis 2 78.00 Quite High
Colon Cancer 37 75.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In accord with the sensitivity of HCT116 cells to resveratrol-induced apoptosis, and paralleling the co-localization of Bax to the mitochondria, ??
Positive_regulation (induced) of Localization (localization) of Bax associated with apoptosis
1) Confidence 0.48 Published 2002 Journal BMC Cancer Section Body Doc Link PMC130964 Disease Relevance 0.74 Pain Relevance 0
m changes, exponentially growing cultures of bax-positive and bax-negative cells were treated with 100 ?
Positive_regulation (growing) of Localization (cultures) of bax-positive
2) Confidence 0.42 Published 2002 Journal BMC Cancer Section Body Doc Link PMC130964 Disease Relevance 0.77 Pain Relevance 0
Diclofenac induced early (9 h) activation of Bax and Bak and caused mitochondrial translocation of Bax, indicating that MOMP was involved in cell death.
Positive_regulation (caused) of Localization (translocation) of Bax associated with diclofenac and death
3) Confidence 0.41 Published 2008 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 18191430 Disease Relevance 0.87 Pain Relevance 0.46
Indeed, phosphorylation of p53 activates the release of cytochrome c and caspase-9 via target genes such as Bax (BCL-2 [B-cell lymphoma-2] associated protein), Bak (BCL-2 homologous antagonist/killer), Noxa (damage), and PUMA (p53 upregulated modulator of apoptosis) [27].
Positive_regulation (activates) of Localization (release) of Bax in B-cell associated with lymphatic system cancer, antagonist and apoptosis
4) Confidence 0.38 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2660376 Disease Relevance 1.15 Pain Relevance 0.05
Upon FR122047 treatment, there were apparent increases in the ratio of Bax to Bcl-2, mitochondrial cytochrome c release, and apoptosis in MCF-7 cells.
Positive_regulation (increases) of Localization (release) of Bax in MCF-7 associated with apoptosis
5) Confidence 0.34 Published 2010 Journal Oncol. Rep. Section Abstract Doc Link 20596620 Disease Relevance 0.90 Pain Relevance 0.26
When Bax and Bak are released, they oligomerize to the outer membrane of the mitochondria, providing a channel for cytochrome c to move into the cytoplasm [69].
Positive_regulation (When) of Localization (released) of Bax
6) Confidence 0.12 Published 2010 Journal Cancer Metastasis Rev Section Body Doc Link PMC2933845 Disease Relevance 0.85 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox