INT148992

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Context Info
Confidence 0.60
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 3
Disease Relevance 2.36
Pain Relevance 1.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
dorsal root ganglion 2
nerve 1
Cd163 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 1 100.00 Very High Very High Very High
dorsal root ganglion 14 98.00 Very High Very High Very High
metalloproteinase 4 95.44 Very High Very High Very High
Neuropathic pain 4 87.76 High High
induced neuropathy 3 75.00 Quite High
peripheral neuropathy 2 66.68 Quite High
Pain 2 65.80 Quite High
Disease Link Frequency Relevance Heat
Apoptosis 2 100.00 Very High Very High Very High
INFLAMMATION 1 100.00 Very High Very High Very High
Ganglion Cysts 16 97.52 Very High Very High Very High
Drug Induced Neurotoxicity 2 96.04 Very High Very High Very High
Neuropathic Pain 9 87.76 High High
Peripheral Neuropathy 2 66.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
By reverse transcription-polymerase chain reaction, the expression levels of MMP-3 and CD163 were markedly up-regulated in paclitaxel-treated dorsal root ganglion.
Gene_expression (expression) of CD163 in dorsal root ganglion associated with ganglion cysts and dorsal root ganglion
1) Confidence 0.60 Published 2008 Journal Cancer Sci. Section Abstract Doc Link 18754875 Disease Relevance 0.95 Pain Relevance 0.68
By reverse transcription-polymerase chain reaction, the expression levels of MMP-3 and CD163 were markedly up-regulated in paclitaxel-treated dorsal root ganglion.
Gene_expression (levels) of CD163 in dorsal root ganglion associated with ganglion cysts and dorsal root ganglion
2) Confidence 0.47 Published 2008 Journal Cancer Sci. Section Abstract Doc Link 18754875 Disease Relevance 0.95 Pain Relevance 0.68
The results indicate that cisplatin affects the expression of several genes associated with apoptosis (Cdkn1a, Ckap2, Bid3, S100a8, S100a9), inflammation (S100a8, S100a9, Cd163, Mmp9), and nerve growth and regeneration (Mmp9, Gfap, Fabp7).
Gene_expression (expression) of Cd163 in nerve associated with inflammation and apoptosis
3) Confidence 0.46 Published 2008 Journal Exp. Neurol. Section Abstract Doc Link 18191839 Disease Relevance 0.46 Pain Relevance 0.11

General Comments

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