INT1490

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Context Info
Confidence 0.21
First Reported 1978
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 0.50
Pain Relevance 4.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Prkacb) nucleus (Prkacb) kinase activity (Prkacb)
cytoplasm (Prkacb)
Prkacb (Mus musculus)
Pain Link Frequency Relevance Heat
Immobilon 20 100.00 Very High Very High Very High
Opioid 4 99.90 Very High Very High Very High
MU agonist 4 99.60 Very High Very High Very High
alcohol 12 99.20 Very High Very High Very High
antagonist 31 99.00 Very High Very High Very High
Anterior cingulate cortex 82 98.88 Very High Very High Very High
opioid receptor 6 98.56 Very High Very High Very High
long-term potentiation 52 98.44 Very High Very High Very High
tolerance 26 97.16 Very High Very High Very High
Hippocampus 3 94.40 High High
Disease Link Frequency Relevance Heat
Targeted Disruption 11 97.44 Very High Very High Very High
Impaired Glucose Tolerance 10 89.04 High High
Morphine Dependence 2 81.92 Quite High
Coronary Heart Disease 4 75.00 Quite High
Pain 24 38.92 Quite Low
Neuropathic Pain 1 34.44 Quite Low
INFLAMMATION 8 33.60 Quite Low
Catalepsy 1 30.80 Quite Low
Toxicity 7 25.00 Low Low
Parkinson's Disease 3 15.60 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Studies suggest that acute and chronic opioids can regulate the cAMP-dependent protein kinase (PKA) signaling pathway and that changes in this pathway may be involved in opioid tolerance.
Regulation (regulate) of cAMP-dependent protein kinase associated with tolerance and opioid
1) Confidence 0.21 Published 2000 Journal Synapse Section Abstract Doc Link 11020235 Disease Relevance 0 Pain Relevance 0.67
On the other hand, the changes in adenylate cyclase and cyclic AMP dependent protein kinase activities were not affected significantly by levallorphan administration.
Neg (not) Regulation (affected) of cyclic AMP dependent protein kinase
2) Confidence 0.17 Published 1978 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 206752 Disease Relevance 0.08 Pain Relevance 0.72
On the other hand, the changes in adenylate cyclase and cyclic AMP dependent protein kinase activities were not affected significantly by levallorphan administration.
Regulation (changes) of cyclic AMP dependent protein kinase
3) Confidence 0.17 Published 1978 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 206752 Disease Relevance 0.08 Pain Relevance 0.72
Role of cAMP-dependent protein kinase (PKA) in opioid agonist-induced mu-opioid receptor downregulation and tolerance in mice.
Regulation (Role) of cAMP-dependent protein kinase associated with mu agonist, tolerance, opioid receptor and immobilon
4) Confidence 0.09 Published 2000 Journal Synapse Section Title Doc Link 11020235 Disease Relevance 0 Pain Relevance 1.04
This results in the opposite regulation of the activity of cAMP-dependent protein kinase involved in modulating the activity of numerous phosphoproteins and transcription factors, which control the expression of immediate early genes, such as c-fos and zif-268, leading to long-term adaptive responses [8,10].
Regulation (regulation) of cAMP-dependent protein kinase
5) Confidence 0.02 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2843608 Disease Relevance 0 Pain Relevance 0.56
This study was designed to examine the impact of cardiac-specific overexpression of alcohol dehydrogenase (ADH) on ethanol-induced change in cardiac contractile function, intracellular Ca2+ homeostasis, insulin and AMP-dependent kinase (AMPK) signaling.


Regulation (change) of AMP-dependent kinase associated with alcohol
6) Confidence 0.02 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2890411 Disease Relevance 0.33 Pain Relevance 0.18
As the downstream target of AC1, cAMP-dependent protein kinase (PKA) may activate MEK and ERK/MAPK.
Regulation (target) of cAMP-dependent protein kinase
7) Confidence 0.02 Published 2009 Journal Mol Pain Section Body Doc Link PMC2734546 Disease Relevance 0 Pain Relevance 0.62

General Comments

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