INT149013

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Context Info
Confidence 0.47
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.10
Pain Relevance 0.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (Tph1)
Anatomy Link Frequency
neurons 1
Tph1 (Mus musculus)
Pain Link Frequency Relevance Heat
Serotonin 41 99.80 Very High Very High Very High
dexamethasone 1 98.56 Very High Very High Very High
monoamine 2 97.96 Very High Very High Very High
Raphe 4 92.88 High High
Neurotransmitter 1 68.92 Quite High
depression 7 64.76 Quite High
Hippocampus 16 49.32 Quite Low
fluoxetine 11 41.44 Quite Low
spastic colon 1 38.72 Quite Low
Eae 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Anxiety Disorder 29 97.24 Very High Very High Very High
Stress 4 95.08 Very High Very High Very High
Targeted Disruption 4 83.44 Quite High
Handedness 12 65.96 Quite High
Depression 7 64.76 Quite High
Vomiting 3 64.32 Quite High
Schizophrenia 2 64.16 Quite High
Neurodegenerative Disease 19 50.00 Quite Low
Autism 3 5.00 Very Low Very Low Very Low
Mental Disorders 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Here, we describe two of a series of these inhibitors that are potent for TPH activity both in biochemical and cell-based assays.
Positive_regulation (potent) of TPH
1) Confidence 0.47 Published 2008 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 18192499 Disease Relevance 0.21 Pain Relevance 0.18
Administration of glucocorticoids to rats results in elevations of the tryptophan-metaboliting enzymes and TPH in vivo and that administration of dexamethasone phosphate regulates TDO activity in cells from control and adrenarectomized mice, respectively [38,39].
Positive_regulation (elevations) of TPH associated with dexamethasone
2) Confidence 0.28 Published 2009 Journal Mol Brain Section Body Doc Link PMC2673217 Disease Relevance 0.83 Pain Relevance 0.08
These neurons do not express tryptophan hydroxylase (Tph) or dopa decarboxylase (Aadc), which are required for serotonin synthesis, or the catabolic enzymes monoamine oxidase A and B.
Positive_regulation (required) of Tph in neurons associated with serotonin and monoamine
3) Confidence 0.19 Published 2010 Journal EMBO J Section Body Doc Link PMC2944059 Disease Relevance 0.07 Pain Relevance 0.38

General Comments

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