INT149013

Context Info Confidence 0.47 First Reported 2008 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 3 Total Number 3 Disease Relevance 1.10 Pain Relevance 0.65

oxidoreductase activity (Tph1)

Anatomy Link Frequency neurons 1 Tph1 (Mus musculus)

Pain Link Frequency Relevance Heat Serotonin 41 99.80 dexamethasone 1 98.56 monoamine 2 97.96 Raphe 4 92.88 Neurotransmitter 1 68.92 depression 7 64.76 Hippocampus 16 49.32 fluoxetine 11 41.44 spastic colon 1 38.72 Eae 10 5.00

Disease Link Frequency Relevance Heat Anxiety Disorder 29 97.24 Stress 4 95.08 Targeted Disruption 4 83.44 Handedness 12 65.96 Depression 7 64.76 Vomiting 3 64.32 Schizophrenia 2 64.16 Neurodegenerative Disease 19 50.00 Autism 3 5.00 Mental Disorders 3 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Here, we describe two of a series of these inhibitors that are potent for TPH activity both in biochemical and cell-based assays.

Positive_regulation (potent) of TPH

1) Confidence 0.47 Published 2008 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 18192499 Disease Relevance 0.21 Pain Relevance 0.18

Administration of glucocorticoids to rats results in elevations of the tryptophan-metaboliting enzymes and TPH in vivo and that administration of dexamethasone phosphate regulates TDO activity in cells from control and adrenarectomized mice, respectively [38,39].

Positive_regulation (elevations) of TPH associated with dexamethasone

2) Confidence 0.28 Published 2009 Journal Mol Brain Section Body Doc Link PMC2673217 Disease Relevance 0.83 Pain Relevance 0.08

These neurons do not express tryptophan hydroxylase (Tph) or dopa decarboxylase (Aadc), which are required for serotonin synthesis, or the catabolic enzymes monoamine oxidase A and B.

Positive_regulation (required) of Tph in neurons associated with serotonin and monoamine

3) Confidence 0.19 Published 2010 Journal EMBO J Section Body Doc Link PMC2944059 Disease Relevance 0.07 Pain Relevance 0.38

General Comments

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