INT149014

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Context Info
Confidence 0.58
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 1.43
Pain Relevance 0.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (Tph1)
Anatomy Link Frequency
blood 1
bowel 1
Tph1 (Mus musculus)
Pain Link Frequency Relevance Heat
Serotonin 79 96.24 Very High Very High Very High
spastic colon 4 93.64 High High
Potency 1 92.52 High High
antidepressant 32 90.04 High High
Neurotransmitter 18 83.32 Quite High
sSRI 28 67.20 Quite High
Catecholamine 2 60.88 Quite High
fluoxetine 19 60.44 Quite High
depression 8 53.28 Quite High
antagonist 3 40.16 Quite Low
Disease Link Frequency Relevance Heat
Gastrointestinal Disease 3 98.64 Very High Very High Very High
Targeted Disruption 196 95.88 Very High Very High Very High
Vomiting 6 94.08 High High
Affective Disorder 10 94.04 High High
Functional Bowel Disorder 4 93.64 High High
Anxiety Disorder 29 53.64 Quite High
Depression 13 53.28 Quite High
Congenital Anomalies 6 51.00 Quite High
Cognitive Disorder 2 22.68 Low Low
Shock 1 9.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The availability of mice with genetic disruption of TPH2 and TPH1/TPH2 provides biologists with a set of important tools for better understanding the roles of serotonin in mammalian physiology and behavior.


Negative_regulation (disruption) of TPH1 associated with serotonin
1) Confidence 0.58 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2565062 Disease Relevance 0.37 Pain Relevance 0.16
Mice lacking Tph1 contain little to no 5-HT in the blood and GI tract while maintaining normal levels in the brain.
Negative_regulation (lacking) of Tph1 in blood
2) Confidence 0.43 Published 2008 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 18192499 Disease Relevance 0.05 Pain Relevance 0.15
To our knowledge this is the first report with full phenotypic evaluation of mice with genetic deletion of Tph2 and of both Tph isoforms.


Negative_regulation (deletion) of Tph
3) Confidence 0.43 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2565062 Disease Relevance 0.60 Pain Relevance 0.08
These TPH1 inhibitors may provide novel treatments for gastrointestinal disorders associated with dysregulation of the serotonergic system, such as chemotherapy-induced emesis and irritable bowel syndrome.
Negative_regulation (inhibitors) of TPH1 in bowel associated with gastrointestinal disease, spastic colon and vomiting
4) Confidence 0.43 Published 2008 Journal J. Med. Chem. Section Abstract Doc Link 18557609 Disease Relevance 0.36 Pain Relevance 0.23
Even though a polymorphism reduces the activity of TPH by 50%, the vesicular and extracellular 5-HT decrease by only 13% (Panel C).
Negative_regulation (reduces) of TPH
5) Confidence 0.12 Published 2010 Journal Theor Biol Med Model Section Body Doc Link PMC2942809 Disease Relevance 0.05 Pain Relevance 0.12

General Comments

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