INT149015

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Context Info
Confidence 0.78
First Reported 2008
Last Reported 2011
Negated 1
Speculated 1
Reported most in Body
Documents 20
Total Number 28
Disease Relevance 9.45
Pain Relevance 10.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (Tph2)
Anatomy Link Frequency
brain 4
neurons 2
dorsal 1
adult brain 1
amygdala 1
Tph2 (Mus musculus)
Pain Link Frequency Relevance Heat
Serotonin 233 100.00 Very High Very High Very High
Inflammation 20 99.76 Very High Very High Very High
Dopamine 105 99.32 Very High Very High Very High
antidepressant 80 98.92 Very High Very High Very High
5HT 5 98.74 Very High Very High Very High
Locus ceruleus 26 98.54 Very High Very High Very High
monoamine 45 98.16 Very High Very High Very High
fluoxetine 62 97.96 Very High Very High Very High
Peripheral nerve injury 1 97.96 Very High Very High Very High
midbrain 15 97.60 Very High Very High Very High
Disease Link Frequency Relevance Heat
Chronic Fatigue Syndrome 249 99.84 Very High Very High Very High
INFLAMMATION 20 99.76 Very High Very High Very High
Hematological Disease 12 99.36 Very High Very High Very High
Nervous System Injury 36 99.08 Very High Very High Very High
Targeted Disruption 410 98.96 Very High Very High Very High
Catalepsy 18 98.42 Very High Very High Very High
Sprains And Strains 55 97.24 Very High Very High Very High
Nociception 49 94.64 High High
Depression 76 93.76 High High
Fatigue 36 91.24 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
No effect on cortical 5-HT1A and 5-HT2A receptor mRNA levels and on 5-HT1A receptor, tph2 (tryptophan hydroxylase-2) and SERT (serotonin transporter) mesencephalic gene expression was observed in ASC mice.
Gene_expression (expression) of tryptophan hydroxylase-2 associated with serotonin
1) Confidence 0.78 Published 2009 Journal Zh Vyssh Nerv Deiat Im I P Pavlova Section Abstract Doc Link 19445393 Disease Relevance 0.72 Pain Relevance 0.55
No effect on cortical 5-HT1A and 5-HT2A receptor mRNA levels and on 5-HT1A receptor, tph2 (tryptophan hydroxylase-2) and SERT (serotonin transporter) mesencephalic gene expression was observed in ASC mice.
Gene_expression (expression) of tph2 associated with serotonin
2) Confidence 0.78 Published 2009 Journal Zh Vyssh Nerv Deiat Im I P Pavlova Section Abstract Doc Link 19445393 Disease Relevance 0.72 Pain Relevance 0.55
Loss of Pet1 in the 5-HTergic neurons leads to a decrease of Tph2 expression but no change in Lmx1b expression.
Gene_expression (expression) of Tph2 in Pet1
3) Confidence 0.75 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3016403 Disease Relevance 0.05 Pain Relevance 0.13
Nevertheless, these results indicate that deleting Lmx1b in the adult brain impairs Tph2 expression, leading to a deficiency of central 5-HT.
Gene_expression (expression) of Tph2 in adult brain
4) Confidence 0.75 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3016403 Disease Relevance 0 Pain Relevance 0.11
We found that the level of central 5-HT in Lmx1b iCKO mice is reduced to 60% of controls, and that the expression of 5-HT neuron-associated genes such as Tph2, Sert and Vmat2 are down-regulated in Lmx1b iCKO mice.
Gene_expression (expression) of Tph2 in 5-HT neuron
5) Confidence 0.75 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3016403 Disease Relevance 0 Pain Relevance 0.31
To explore the mechanisms underlying decreased 5-HT level in Lmx1b iCKO mice, we examined the expression of Tph2, which is a specific enzyme for synthesis of 5-HT in the brain [21].
Spec (examined) Gene_expression (expression) of Tph2 in brain
6) Confidence 0.75 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3016403 Disease Relevance 0 Pain Relevance 0.11
G418/FIAU resistant ES-cell clones for TPH2 deletion were analyzed by southern hybridization with a 217 bp 3?
Gene_expression (deletion) of TPH2
7) Confidence 0.67 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2565062 Disease Relevance 0 Pain Relevance 0
[Effects of chronic fluoxetine treatment on catalepsy and immune response in mice genetically predisposed to freezing reaction: the role of 5-HT1A and 5-HT2A receptors and tph2 and SERT genes].
Gene_expression (role) of tph2 associated with catalepsy and fluoxetine
8) Confidence 0.67 Published 2009 Journal Zh Vyssh Nerv Deiat Im I P Pavlova Section Title Doc Link 19445393 Disease Relevance 0.81 Pain Relevance 0.55
Subclasses of CFS have been associated with polymorphisms in genes that function in the HPA axis NR3C1, TPH2 and MAOA [37-39].
Gene_expression (axis) of TPH2 associated with chronic fatigue syndrome
9) Confidence 0.61 Published 2008 Journal BMC Syst Biol Section Body Doc Link PMC2625353 Disease Relevance 1.28 Pain Relevance 0.24
We considered 36 autosomal SNPs that the CDC had selected from eight candidate CFS genes, TPH2 (SNPs selected from locus 12q21), POMC (2p24), NR3C1 (5q34), CRHR2 (7p15), TH (11p15), SLC6A4 (17q11.1), CRHR1 (17q21), COMT (22q11.1) [38].
Gene_expression (selected) of TPH2 associated with chronic fatigue syndrome
10) Confidence 0.61 Published 2008 Journal BMC Syst Biol Section Body Doc Link PMC2625353 Disease Relevance 0.19 Pain Relevance 0
Indeed, IPA positioned TPH2 within the top hematological disease pathway containing 12 candidate genes.
Gene_expression (positioned) of TPH2 associated with hematological disease
11) Confidence 0.61 Published 2008 Journal BMC Syst Biol Section Body Doc Link PMC2625353 Disease Relevance 0.84 Pain Relevance 0.04
Generation of TPH1, TPH2 and TPH1/TPH2 deficient animals
Gene_expression (Generation) of TPH2
12) Confidence 0.60 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2565062 Disease Relevance 0.58 Pain Relevance 0.08
The further reduction in brain 5HT in the DKO may suggest that TPH1 can provide some 5-HT in the absence of TPH2, either in situ or transposed from the blood.
Neg (absence) Gene_expression (absence) of TPH2 in blood associated with targeted disruption and 5ht
13) Confidence 0.60 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2565062 Disease Relevance 0.85 Pain Relevance 0.70
Generation of TPH1, TPH2 and TPH1/TPH2 deficient animals
Gene_expression (Generation) of TPH2
14) Confidence 0.60 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2565062 Disease Relevance 0.58 Pain Relevance 0.08
The expression of Tph2 in the dorsal root ganglia (DRGs) increased after peripheral nerve injury of the sciatic nerve in the Spared Nerve Injury model (SNI) in C57Bl/6 mice (Figure 1a).
Gene_expression (expression) of Tph2 in sciatic nerve associated with nervous system injury, sciatic nerve and peripheral nerve injury
15) Confidence 0.60 Published 2010 Journal Mol Pain Section Body Doc Link PMC2987995 Disease Relevance 0.76 Pain Relevance 0.73
Fluoxetine decreased glucocorticoid receptor (GR) gene expression in the prefrontal cortex, amygdala, locus coeruleus and dorsal raphé nucleus, and increased locus coeruleus tyrosine hydroxylase and dorsal raphé nucleus tryptophan hydroxylase-2 (TPH2) gene expression.
Gene_expression (pression. ) of TPH2 in cortex associated with locus ceruleus, amygdala and fluoxetine
16) Confidence 0.59 Published 2010 Journal Eur. J. Neurosci. Section Abstract Doc Link 20374287 Disease Relevance 0.34 Pain Relevance 1.09
After administration of tamoxifen, the level of 5-HT in the brain of Lmx1b iCKO mice was reduced to 60% of that in control mice, and the expression of tryptophan hydroxylase 2 (Tph2), serotonin transporter (Sert) and vesicular monoamine transporter 2 (Vmat2) was greatly down-regulated.
Gene_expression (expression) of Tph2 in brain associated with serotonin and monoamine
17) Confidence 0.58 Published 2011 Journal PLoS ONE Section Abstract Doc Link PMC3016403 Disease Relevance 0 Pain Relevance 0.26
Our results reveal that Lmx1b is required for the biosynthesis of 5-HT in adult mouse brain, and it may be involved in maintaining normal functions of central 5-HTergic neurons by regulating the expression of Tph2, Sert and Vmat2.



Gene_expression (expression) of Tph2 in neurons
18) Confidence 0.58 Published 2011 Journal PLoS ONE Section Abstract Doc Link PMC3016403 Disease Relevance 0 Pain Relevance 0.24
-gal-positive neurons expressed Tph2, and approximately 85% of Tph2-labeled neurons were ?
Gene_expression (expressed) of Tph2 in neurons
19) Confidence 0.58 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3016403 Disease Relevance 0.07 Pain Relevance 0.12
After administration of tamoxifen, the level of 5-HT in the brain of Lmx1b iCKO mice was reduced to 60% of that in control mice, and the expression of tryptophan hydroxylase 2 (Tph2), serotonin transporter (Sert) and vesicular monoamine transporter 2 (Vmat2) was greatly down-regulated.
Gene_expression (expression) of tryptophan hydroxylase 2 in brain associated with serotonin and monoamine
20) Confidence 0.58 Published 2011 Journal PLoS ONE Section Abstract Doc Link PMC3016403 Disease Relevance 0 Pain Relevance 0.26

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