INT149027

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Context Info
Confidence 0.36
First Reported 2007
Last Reported 2009
Negated 0
Speculated 1
Reported most in Abstract
Documents 8
Total Number 9
Disease Relevance 4.27
Pain Relevance 0.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (C1s) extracellular region (C1s)
Anatomy Link Frequency
colon 1
bowel 1
C1s (Mus musculus)
Pain Link Frequency Relevance Heat
spastic colon 4 99.18 Very High Very High Very High
Inflammation 10 68.56 Quite High
agonist 2 64.44 Quite High
Visceral pain 2 62.28 Quite High
antagonist 2 25.00 Low Low
Antinociceptive 1 25.00 Low Low
hypoalgesia 1 25.00 Low Low
Inflammatory response 2 15.84 Low Low
ischemia 12 5.00 Very Low Very Low Very Low
cva 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

34 99.56 Very High Very High Very High
Diarrhoea 7 99.24 Very High Very High Very High
Functional Bowel Disorder 4 99.18 Very High Very High Very High
Hypersensitivity 6 95.44 Very High Very High Very High
Inflammatory Bowel Disease 11 82.64 Quite High
INFLAMMATION 12 68.56 Quite High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super / Visceral Pain

2 62.28 Quite High
Myocardial Infarction 49 54.76 Quite High
Coronary Artery Disease 16 53.84 Quite High
Heart Disease 2 52.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Increased faecal serine protease activity in diarrhoeic IBS patients: a colonic lumenal factor impairing colonic permeability and sensitivity.
Positive_regulation (Increased) of serine protease
1) Confidence 0.36 Published 2008 Journal Gut Section Title Doc Link 18194983 Disease Relevance 0.19 Pain Relevance 0.09
OBJECTIVES: Diarrhoea-predominant irritable bowel syndrome (IBS-D) is characterised by elevated colonic lumenal serine protease activity.
Positive_regulation (elevated) of serine protease in bowel associated with diarrhoea and spastic colon
2) Confidence 0.31 Published 2008 Journal Gut Section Abstract Doc Link 18194983 Disease Relevance 0.20 Pain Relevance 0.10
RESULTS: The threefold increase in faecal serine protease activity seen in IBS-D patients compared with constipation-predominant IBS (IBS-C) or infectious diarrhoea is of neither epithelial nor inflammatory cell origin, nor is it coupled with antiprotease activity of endogenous origin.
Positive_regulation (increase) of serine protease
3) Confidence 0.24 Published 2008 Journal Gut Section Body Doc Link 18194983 Disease Relevance 0 Pain Relevance 0
The aims of this study were (1) to investigate the origin of this elevated serine protease activity, (2) to evaluate if it may be sufficient to trigger alterations in colonic paracellular permeability (CPP) and sensitivity, and (3) to examine the role of the proteinase-activated receptor-2 (PAR-2) activation and signalling cascade in this process.
Spec (investigate) Positive_regulation (elevated) of serine protease
4) Confidence 0.24 Published 2008 Journal Gut Section Abstract Doc Link 18194983 Disease Relevance 0.19 Pain Relevance 0.09
Activated C1s cleaves C4 and C2 to form C4b and C2b, respectively, which then combine to form the C3 convertase of the classical complement pathway (Figure 1).
Positive_regulation (Activated) of C1s
5) Confidence 0.15 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727911 Disease Relevance 0.26 Pain Relevance 0
Elevated colonic luminal serine-protease (Ser-P) activity of diarrhea-predominant IBS (IBS-D) patients evokes a proteinase-activated receptor (PAR)-2-mediated colonic hypersensitivity in mice.
Positive_regulation (Elevated) of serine-protease associated with diarrhoea
6) Confidence 0.09 Published 2009 Journal Pain Section Abstract Doc Link 19450926 Disease Relevance 0.39 Pain Relevance 0
The highly related serine protease known also as neutrophil elastase, proteinase 3 and cathepsin G are exclusively detected in promyelocytes and packaged in azurophil granules [57,58], whereas carbonic anhydrase 1 is expressed in adult human and mouse erythroid cells and colon epithelia, from two distinct promoters [59].
Positive_regulation (packaged) of serine protease in colon
7) Confidence 0.03 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1888706 Disease Relevance 0.07 Pain Relevance 0.03
A recent study has evidenced that stool supernatants from diarrhea predominant IBS patients have a high level of serine-protease activity that increases permeability and colonic hypersensitivity when infused intra-colonically in mice, and these effects are linked to activation of PAR-2 receptors.
Positive_regulation (level) of serine-protease associated with diarrhoea
8) Confidence 0.03 Published 2008 Journal Eur Rev Med Pharmacol Sci Section Abstract Doc Link 18924448 Disease Relevance 0.34 Pain Relevance 0.09
A recent study has evidenced that stool supernatants from diarrhea predominant IBS patients have a high level of serine-protease activity that increases permeability and colonic hypersensitivity when infused intra-colonically in mice, and these effects are linked to activation of PAR-2 receptors.
Positive_regulation (increases) of serine-protease associated with diarrhoea
9) Confidence 0.03 Published 2008 Journal Eur Rev Med Pharmacol Sci Section Abstract Doc Link 18924448 Disease Relevance 0.34 Pain Relevance 0.09

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