INT14903

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Context Info
Confidence 0.57
First Reported 1989
Last Reported 2011
Negated 0
Speculated 1
Reported most in Body
Documents 81
Total Number 83
Disease Relevance 42.02
Pain Relevance 6.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (SOD1) peroxisome (SOD1) protein complex (SOD1)
cytoplasm (SOD1) cytosol (SOD1) extracellular space (SOD1)
Anatomy Link Frequency
erythrocyte 4
liver 4
kidney 3
plasma 2
brain 2
SOD1 (Homo sapiens)
Pain Link Frequency Relevance Heat
isoflurane 10 99.98 Very High Very High Very High
cINOD 27 99.68 Very High Very High Very High
tolerance 49 99.28 Very High Very High Very High
agonist 62 98.00 Very High Very High Very High
Paracetamol 8 97.80 Very High Very High Very High
anesthesia 36 97.68 Very High Very High Very High
Osteoarthritis 47 97.60 Very High Very High Very High
Glutamate 5 96.00 Very High Very High Very High
halothane 6 95.60 Very High Very High Very High
Inflammation 344 95.08 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 804 100.00 Very High Very High Very High
Heart Rate Under Development 31 100.00 Very High Very High Very High
Arrhythmias 2 Under Development 12 100.00 Very High Very High Very High
Neutropenia 3 99.96 Very High Very High Very High
Adenocarcinoma 85 99.88 Very High Very High Very High
Chronic Renal Failure 119 99.76 Very High Very High Very High
Leukopenia 2 99.70 Very High Very High Very High
Hypertension 120 99.56 Very High Very High Very High
Hyperplasia 115 99.48 Very High Very High Very High
Stomach Cancer 29 99.48 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The increased ROS levels experienced by cells in wounded tissue may be exacerbated by the depletion of antioxidant enzymes including Cu/Zn superoxide dismutase (SOD1) and glutathione peroxidase [19].
Negative_regulation (depletion) of Cu/Zn superoxide dismutase
1) Confidence 0.57 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2850366 Disease Relevance 0.73 Pain Relevance 0.15
Moreover, the fact that mouse SOD1 was significantly decreased in hemizygous and homozygous SOD1-TGs may indicate functionality and inclusion into the regulative system of SOD1.


Negative_regulation (decreased) of SOD1
2) Confidence 0.51 Published 2004 Journal Proteome Sci Section Body Doc Link PMC446209 Disease Relevance 0.08 Pain Relevance 0.11
2610008O03Rik protein (Q9D0K2) was detected in 2-DE gels as one spot (Fig. 1) and expression level of 2610008O03Rik protein was significantly decreased in homozygous SOD1-TG as compared to wild types (P < 0.05).
Negative_regulation (decreased) of SOD1
3) Confidence 0.51 Published 2004 Journal Proteome Sci Section Body Doc Link PMC446209 Disease Relevance 0 Pain Relevance 0.04
Decreased SOD activities are thought to be related with the increased superoxide anion.
Negative_regulation (Decreased) of SOD
4) Confidence 0.51 Published 2003 Journal Drug Chem Toxicol Section Abstract Doc Link 12953657 Disease Relevance 0.14 Pain Relevance 0.25
SOD activity and AOP levels were significantly decreased in all NSAID groups when we compared the values before and after 21 days of celecoxib, meloxicam, ibuprofen treatment.
Negative_regulation (decreased) of SOD associated with cinod
5) Confidence 0.51 Published 2003 Journal Drug Chem Toxicol Section Abstract Doc Link 12953657 Disease Relevance 0.16 Pain Relevance 0.25
Isoflurane had no effect on plasma antioxidant enzymes, but, similar to the others, isoflurane decreased the plasma zinc levels, erythrocyte SOD and GSH-Px activities and trace element levels.
Negative_regulation (decreased) of SOD in erythrocyte associated with isoflurane
6) Confidence 0.51 Published 2004 Journal Biol Trace Elem Res Section Abstract Doc Link 15621932 Disease Relevance 0 Pain Relevance 0.46
A marked reduction in plasma SOD like activity was obtained during surgery in any type of anesthesia in this study.
Negative_regulation (reduction) of SOD in plasma associated with anesthesia
7) Confidence 0.50 Published 1990 Journal Masui Section Abstract Doc Link 2246807 Disease Relevance 0 Pain Relevance 0.39
Surgical duration over two hours was the most contributing factor to reduce the SOD like activity.
Negative_regulation (reduce) of SOD
8) Confidence 0.43 Published 1990 Journal Masui Section Abstract Doc Link 2246807 Disease Relevance 0 Pain Relevance 0.35
Superoxide dismutase 1 activity evaluation
Negative_regulation (evaluation) of Superoxide dismutase 1
9) Confidence 0.42 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2768759 Disease Relevance 0 Pain Relevance 0
Besides, they also showed a trend toward improving antioxidant enzymes and glucose tolerance as compared to the D + GNO group, whereas D + PO treatment aggravated the dyslipidemic condition while causing a significant decrease in the superoxide dismutase levels when compared to N rats fed with GNO (N + GNO).
Negative_regulation (decrease) of superoxide dismutase associated with tolerance and impaired glucose tolerance
10) Confidence 0.42 Published 2010 Journal Indian Journal of Pharmacology Section Abstract Doc Link PMC2937313 Disease Relevance 0.79 Pain Relevance 0.21
Pathological insights are primarily derived from animal studies and include, among others, defects of superoxide dismutase – 1, disorganization of the intermediate filament, abnormal intracellular free calcium levels, and glutamate excitotoxicity which are considered to be responsible for mitochondrial abnormalities and energetic distress leading to cell injury and motor neuron death [3,4,8].
Negative_regulation (defects) of superoxide dismutase in motor neuron associated with glutamate, congenital anomalies, injury and death
11) Confidence 0.42 Published 2008 Journal Cases J Section Body Doc Link PMC2600792 Disease Relevance 1.66 Pain Relevance 0.05
We also demonstrate that loss of Cu/Zn-superoxide dismutase stability relates to faster ALS patient death.
Negative_regulation (loss) of Cu/Zn-superoxide dismutase associated with death and motor neuron diseases
12) Confidence 0.42 Published 2008 Journal PLoS Biology Section Abstract Doc Link PMC2486295 Disease Relevance 1.23 Pain Relevance 0.03
This last phenomenon was reflected in the CVF since the total antioxidant capacity of CVF decreased drastically during labour, largely due to a decline in copper zinc superoxide dismutase and thioredoxin-4 CVF concentrations.
Negative_regulation (decline) of superoxide dismutase
13) Confidence 0.41 Published 2010 Journal Proteome Sci Section Body Doc Link PMC3016264 Disease Relevance 0.16 Pain Relevance 0.03
Serum SOD activity was significantly decreased in T1DM and T2DM subjects compared to the control subjects (p < 0,05).
Negative_regulation (decreased) of SOD
14) Confidence 0.41 Published 2008 Journal BMC Med Genet Section Abstract Doc Link PMC2386118 Disease Relevance 0.64 Pain Relevance 0
We also confirmed known fact that serum SOD activity is significantly reduced in patients with DM [25].
Negative_regulation (reduced) of SOD associated with diabetes mellitus
15) Confidence 0.41 Published 2008 Journal BMC Med Genet Section Body Doc Link PMC2386118 Disease Relevance 1.04 Pain Relevance 0
It is known that deficiency in SOD1 results in increased levels of vascular superoxide and peroxynitrite and impaired endothelium-dependent relaxation in both large arteries and microvessels [31] and caused hypertrophy of arteries [32].
Negative_regulation (deficiency) of SOD1 in endothelium associated with hypertrophy
16) Confidence 0.41 Published 2008 Journal BMC Med Genet Section Body Doc Link PMC2386118 Disease Relevance 0.21 Pain Relevance 0
Serum SOD activity was significantly decreased in T1DM (0,75 ± 0,18 U; 95% CI: 0,72, 0,79) and in T2DM patients (0,71 ± 0,33; 95% CI: 0,67, 0,74) compared to the control subjects (1,67 ± 0,33, 95% CI: 1,61, 1,72), both p < 0,01.
Negative_regulation (decreased) of SOD
17) Confidence 0.41 Published 2008 Journal BMC Med Genet Section Body Doc Link PMC2386118 Disease Relevance 0.42 Pain Relevance 0
Therefore, this is the first study to the author's knowledge, to show a decrease in SOD activity following CoQ10 supplementation in healthy individuals.
Negative_regulation (decrease) of SOD associated with stress
18) Confidence 0.39 Published 2008 Journal J Int Soc Sports Nutr Section Body Doc Link PMC2315638 Disease Relevance 0.71 Pain Relevance 0
Our results showed a significant decrease of GSH levels, AA levels and SOD activity and an increase of MDA and GSSG levels after APAP administration.
Negative_regulation (decrease) of SOD associated with paracetamol
19) Confidence 0.39 Published 2007 Journal Phytomedicine Section Abstract Doc Link 16638633 Disease Relevance 0.27 Pain Relevance 0.56
RESULTS: Cytoplasmic values of manganese SOD, catalase, and glutathione peroxidase were decreased in pancreatic cells from chronic pancreatitis specimens when compared with normal pancreas.
Negative_regulation (decreased) of SOD in pancreas
20) Confidence 0.38 Published 2003 Journal Pancreas Section Body Doc Link 12499913 Disease Relevance 0 Pain Relevance 0

General Comments

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