INT149030

Context Info Confidence 0.58 First Reported 2007 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 4 Total Number 5 Disease Relevance 0.96 Pain Relevance 0.13

Golgi apparatus (Tjp1) plasma membrane (Tjp1) nucleus (Tjp1) cytoplasm (Tjp1)

Tjp1 (Mus musculus)

Pain Link Frequency Relevance Heat Crohn's disease 8 90.40 Inflammation 20 55.68 cytokine 4 54.12 Versed 4 5.00 spastic colon 3 5.00 tetrodotoxin 2 5.00 anesthesia 2 5.00

Disease Link Frequency Relevance Heat Colitis 62 97.40 Disease 8 90.40 Weight Loss 4 89.28 Gastrointestinal Disease 8 75.32 Inflammatory Bowel Disease 34 65.84 INFLAMMATION 18 55.68 Irritable Bowel Syndrome / Irritable Bowel Syndrome Super 6 50.00 Acquired Immune Deficiency Syndrome Or Hiv Infection 10 19.88 Injury 2 18.16 Infection 8 17.88

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Moreover, using a mouse colitis model, Resta-Lenert et al. have shown that the increase in intestinal permeability is associated with a decrease of occludin and ZO-1 phosphorylation [54].

Phosphorylation (phosphorylation) of ZO-1 associated with colitis

1) Confidence 0.58 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2110898 Disease Relevance 0.77 Pain Relevance 0.07

Zonula occludens-1 (ZO-1) and phosphorylated myosin light chain were detected by immunohistochemistry.

Phosphorylation (phosphorylated) of ZO-1

2) Confidence 0.45 Published 2008 Journal Gut Section Body Doc Link 18194983 Disease Relevance 0 Pain Relevance 0

In mice, colonic exposure to supernatants from IBS-D patients resulted in a rapid increase in the phosphorylation of myosin light chain and delayed redistribution of ZO-1 in colonocytes.

Phosphorylation (phosphorylation) of ZO-1

3) Confidence 0.45 Published 2008 Journal Gut Section Body Doc Link 18194983 Disease Relevance 0 Pain Relevance 0

Zonula occludens-1 (ZO-1) and phosphorylated myosin light chain were detected by immunohistochemistry.

Phosphorylation (phosphorylated) of Zonula occludens-1

4) Confidence 0.45 Published 2008 Journal Gut Section Body Doc Link 18194983 Disease Relevance 0 Pain Relevance 0

This hypothesis is also supported by a recent study demonstrating that probiotic Streptococcus thermophilus and Lactobacillus acidophilus can prevent invasion of enteroinvasive E. coli and enhance intestinal epithelial barrier function by amplifying phosphorylation of occludin and ZO-1 in vitro [19].

Phosphorylation (phosphorylation) of ZO-1

5) Confidence 0.44 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2110898 Disease Relevance 0.19 Pain Relevance 0.05

General Comments

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