INT149066

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Context Info
Confidence 0.44
First Reported 2007
Last Reported 2008
Negated 1
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 0.89
Pain Relevance 2.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lyase activity (CA3) cytoplasm (CA3)
Anatomy Link Frequency
neurons 1
medial 1
hilus 1
CA3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Pyramidal cell 23 100.00 Very High Very High Very High
long-term potentiation 16 100.00 Very High Very High Very High
Morphine 7 99.48 Very High Very High Very High
Hippocampus 30 97.92 Very High Very High Very High
Limbic system 3 94.40 High High
opiate 1 94.32 High High
nMDA receptor antagonist 4 81.68 Quite High
Opioid 3 79.20 Quite High
opioid receptor 3 76.52 Quite High
antagonist 3 73.20 Quite High
Disease Link Frequency Relevance Heat
Toxicity 29 100.00 Very High Very High Very High
Epilepsy 22 93.96 High High
Aging 2 91.88 High High
Pressure And Volume Under Development 7 90.08 High High
Neurodegenerative Disease 2 83.56 Quite High
Brain Disease 5 69.88 Quite High
Poisoning 23 67.28 Quite High
Gliosis 8 30.32 Quite Low
Cognitive Disorder 19 15.28 Low Low
Frailty 7 13.36 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, in medial perforant path projections to the dentate gyrus and CA3 region, both LTP induction and the maintenance of E- and L-LTP were unaffected by prenatal morphine treatment.
Neg (unaffected) Regulation (unaffected) of CA3 in medial associated with long-term potentiation and morphine
1) Confidence 0.44 Published 2008 Journal J. Neurophysiol. Section Abstract Doc Link 18199817 Disease Relevance 0.09 Pain Relevance 1.81
The hippocampus (Figure 1) [107], among other brain regions, has been identified as a specific target site having high sensitivity to DOM toxicity, particularly the pyramidal neurons in the CA3, CA4 or hilus of the dentate gyrus [DG] [93,96,98–101,103,104,106,108].
Regulation (sensitivity) of CA3 in hilus associated with toxicity, pyramidal cell and hippocampus
2) Confidence 0.09 Published 2008 Journal Marine Drugs Section Body Doc Link PMC2525487 Disease Relevance 0.70 Pain Relevance 0.15
Field potentials were recorded from CA1 or CA3 stratum pyramidale or st. radiatum using carbon fibre electrodes, of a diameter either 7 ?
Regulation (recorded) of CA3
3) Confidence 0.09 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1950312 Disease Relevance 0 Pain Relevance 0.07
For instance, in CA1 the mean values of amplitude, half-width and duration of SPWs were respectively 0.21 ± 0.02 mV (n = 63), 25.0 ± 1.0 ms (n = 46) and 79.0 ± 6.3 ms (n = 46); the corresponding values in CA3 (n = 11) were respectively 0.27 ± 0.05 mV, 24 ± 1.2 ms and 83.0 ± 9.9 ms.
Regulation (values) of CA3
4) Confidence 0.05 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1950312 Disease Relevance 0 Pain Relevance 0
Experiments suggest that Ca2+ channels are abundant in CA3 neurons and contribute to bursting [24], [25], [26], [27].
Regulation (abundant) of CA3 in neurons
5) Confidence 0.04 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2323611 Disease Relevance 0.09 Pain Relevance 0

General Comments

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