INT149068

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Context Info
Confidence 0.44
First Reported 2008
Last Reported 2009
Negated 0
Speculated 1
Reported most in Body
Documents 3
Total Number 7
Disease Relevance 3.77
Pain Relevance 2.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Cxcr4) cytoplasmic membrane-bounded vesicle (Cxcr4) plasma membrane (Cxcr4)
signal transducer activity (Cxcr4)
Anatomy Link Frequency
neurons 2
sensory neurons 1
IB4 1
bladder 1
Cxcr4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 90 100.00 Very High Very High Very High
opioid receptor 6 100.00 Very High Very High Very High
Inflammation 45 99.90 Very High Very High Very High
nociceptor 25 98.04 Very High Very High Very High
dorsal root ganglion 214 97.20 Very High Very High Very High
hyperexcitability 5 97.00 Very High Very High Very High
cytokine 21 95.90 Very High Very High Very High
chemokine 280 92.84 High High
Enkephalin 1 92.80 High High
Peripheral nerve injury 15 92.24 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 56 99.90 Very High Very High Very High
Cystitis 17 99.24 Very High Very High Very High
Injury 171 98.96 Very High Very High Very High
Neuropathic Pain 81 98.82 Very High Very High Very High
Ganglion Cysts 214 97.20 Very High Very High Very High
Nervous System Injury 40 92.24 High High
Rheumatoid Arthritis 50 91.08 High High
Nociception 35 89.60 High High
Acquired Immune Deficiency Syndrome Or Hiv Infection 106 89.20 High High
Pain 30 86.04 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Therefore, we examined: 1) location of cytokine receptor CXCR4 in the rat bladder; 2) baseline bladder levels of SDF-1 (cognate ligand for CXCR4) and changes in response to a chemically-induced (cyclophosphamide; CYP) model of bladder inflammation; 3) CXCR4 expression changes after CYP-induced cystitis and 4) association between CXCR4 and MIF in the bladder before and after CYP-induced cystitis.
Regulation (changes) of CXCR4 in bladder associated with inflammation, cystitis and cytokine
1) Confidence 0.44 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2588654 Disease Relevance 0.75 Pain Relevance 0.21
To further characterize changes in CXCR4 receptor following gp120/ddC treatment, colocalization experiments were performed with IB4 and TRPV1.
Regulation (changes) of CXCR4 receptor in IB4
2) Confidence 0.38 Published 2009 Journal Mol Pain Section Body Doc Link PMC2734548 Disease Relevance 0.28 Pain Relevance 0.17
As such, it is quite possible that the population of CCR2 or CXCR4 positive neurons is directly linked to the production of chronic neuronal hyperexcitability.
Spec (possible) Regulation (population) of CXCR4 in neurons associated with hyperexcitability
3) Confidence 0.38 Published 2009 Journal Mol Pain Section Body Doc Link PMC2734548 Disease Relevance 0.24 Pain Relevance 0.37
However, following this treatment combination only AMD3100 a CXCR4 antagonist was effective in reversing mechanical hypernociception.
Regulation (effective) of CXCR4 associated with antagonist
4) Confidence 0.38 Published 2009 Journal Mol Pain Section Body Doc Link PMC2734548 Disease Relevance 0.66 Pain Relevance 0.38
Previous studies of neuropathic injury in rodents have demonstrated ddC treatment induced changes in SDF1/CXCR4 signaling by neurons [22].
Regulation (changes) of CXCR4 in neurons associated with injury and neuropathic pain
5) Confidence 0.38 Published 2009 Journal Mol Pain Section Body Doc Link PMC2734548 Disease Relevance 1.07 Pain Relevance 0.37
Our data indicate that CXCR4 and DOR form heterodimeric complexes that are dynamically regulated by the ligands.
Regulation (regulated) of CXCR4 associated with opioid receptor
6) Confidence 0.23 Published 2008 Journal Eur. J. Immunol. Section Abstract Doc Link 18200497 Disease Relevance 0.25 Pain Relevance 0.63
Consistent with previous observations, immunohistochemical techniques used in these experiments revealed non-neuronal CXCR4 immunoreactivity present in both naïve (see additional file 1B and 1D) and sham treated sensory neurons (Fig. 4A, B).
Regulation (immunoreactivity) of CXCR4 in sensory neurons
7) Confidence 0.23 Published 2009 Journal Mol Pain Section Body Doc Link PMC2734548 Disease Relevance 0.52 Pain Relevance 0.34

General Comments

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