INT149069

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.68
First Reported 2007
Last Reported 2010
Negated 2
Speculated 1
Reported most in Body
Documents 24
Total Number 25
Disease Relevance 12.21
Pain Relevance 9.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Cxcr4) cytoplasmic membrane-bounded vesicle (Cxcr4) plasma membrane (Cxcr4)
signal transducer activity (Cxcr4)
Anatomy Link Frequency
bladder 6
neurons 2
spinal cord 1
nerve 1
bone marrow 1
Cxcr4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
chemokine 703 100.00 Very High Very High Very High
opioid receptor 8 99.98 Very High Very High Very High
Inflammation 384 99.74 Very High Very High Very High
Central grey 5 99.64 Very High Very High Very High
Stimulus evoked pain 26 99.48 Very High Very High Very High
Cannabinoid 3 99.20 Very High Very High Very High
dorsal root ganglion 338 99.08 Very High Very High Very High
Spinal cord 46 99.04 Very High Very High Very High
Lasting pain 33 98.68 Very High Very High Very High
Analgesic 5 98.68 Very High Very High Very High
Disease Link Frequency Relevance Heat
Injury 355 99.98 Very High Very High Very High
Hypersensitivity 54 99.90 Very High Very High Very High
Cystitis 187 99.84 Very High Very High Very High
INFLAMMATION 414 99.74 Very High Very High Very High
Urological Neuroanatomy 5 99.64 Very High Very High Very High
Pain 99 99.48 Very High Very High Very High
Hypoxia 2 99.36 Very High Very High Very High
Spinal Cord Injury 57 99.18 Very High Very High Very High
Ganglion Cysts 339 99.08 Very High Very High Very High
Demyelinating Disease 73 98.04 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Second, CXCR4 activation may mediate pain hypersensitivity in the bladder.
Positive_regulation (activation) of CXCR4 in bladder associated with hypersensitivity and stimulus evoked pain
1) Confidence 0.68 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2588654 Disease Relevance 1.21 Pain Relevance 0.64
Real-time PCR showed that CXCR4 mRNA was significantly upregulated in the bladder following CYP treatment (Figure 5A; ?
Positive_regulation (upregulated) of CXCR4 mRNA in bladder
2) Confidence 0.68 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2588654 Disease Relevance 0 Pain Relevance 0
In summary, the chemokine receptor CXCR4 is constitutively expressed in rat urothelium (in basal and intermediate cells) while CYP-induced bladder inflammation resulted in upregulation of CXCR4 and immunostaining of superficial cells (previously devoid of CXCR4).
Positive_regulation (upregulation) of CXCR4 in bladder associated with chemokine and inflammation
3) Confidence 0.68 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2588654 Disease Relevance 0.73 Pain Relevance 0.63
Our results show that both CXCR4 and SDF-1 are constitutively expressed in normal rat bladder and upregulated during CYP-induced cystitis.
Positive_regulation (upregulated) of CXCR4 in bladder associated with cystitis
4) Confidence 0.68 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2588654 Disease Relevance 0.74 Pain Relevance 0.15
We have previously shown that ddC treatment alone resulted in the upregulation of CXCR4 and SDF1 mostly in glia, but also in some neurons of the DRG.
Positive_regulation (upregulation) of CXCR4 in neurons associated with dorsal root ganglion
5) Confidence 0.58 Published 2009 Journal Mol Pain Section Body Doc Link PMC2734548 Disease Relevance 0.85 Pain Relevance 0.48
CCR2, CXCR4, CXCR3 and CCR5 upregulation in L4–L5 DRG after unilateral LPC-induced nerve demyelination
Positive_regulation (upregulation) of CXCR4 in nerve associated with demyelination
6) Confidence 0.54 Published 2007 Journal Mol Pain Section Body Doc Link PMC2228278 Disease Relevance 0.97 Pain Relevance 0.70
Densitometric analysis showed an increase of 3.5 fold in CXCR4-MIF complexes in CYP treated rats compared to saline controls.


Positive_regulation (increase) of CXCR4
7) Confidence 0.49 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2588654 Disease Relevance 0.15 Pain Relevance 0.08
In CYP-induced cystitis, then, activation of CXCR4 receptors, either by its recognized ligand SDF-1 (upregulated as a result of CYP) or due to interaction with MIF (also upregulated as a result of CYP and present in greater quantities than SDF-1) may in fact be contributing to pain hypersensitivity.
Spec (may) Positive_regulation (activation) of CXCR4 associated with hypersensitivity, stimulus evoked pain and cystitis
8) Confidence 0.49 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2588654 Disease Relevance 1.28 Pain Relevance 0.85
CYP treatment although producing CXCR4 mRNA upregulation (a novel finding) did not result in increased CXCR4 protein levels, and scoring of CXCR4 immunostaining actually showed a decrease in staining intensity following CYP treatment.
Positive_regulation (upregulation) of CXCR4 mRNA
9) Confidence 0.49 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2588654 Disease Relevance 0.16 Pain Relevance 0.08
CYP treatment although producing CXCR4 mRNA upregulation (a novel finding) did not result in increased CXCR4 protein levels, and scoring of CXCR4 immunostaining actually showed a decrease in staining intensity following CYP treatment.
Neg (not) Positive_regulation (result) of CXCR4 protein
10) Confidence 0.46 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2588654 Disease Relevance 0.16 Pain Relevance 0.08
Examining the differences between MIF activation of CXCR4 receptors versus MIF activation of CD74 receptors then might provide insights into the actual mechanism for MIF-mediated effects in the bladder and possibly other sites.


Positive_regulation (activation) of CXCR4 in bladder
11) Confidence 0.46 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2588654 Disease Relevance 0.54 Pain Relevance 0.33
Thus our findings indicate that bladder injury produced by CYP-treatment results in mRNA upregulation of the chemokine receptor CXCR4 and increased protein levels of its cognate ligand, SDF-1.
Positive_regulation (upregulation) of CXCR4 in bladder associated with chemokine and injury
12) Confidence 0.46 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2588654 Disease Relevance 0.30 Pain Relevance 0.25
CYP treatment although producing CXCR4 mRNA upregulation (a novel finding) did not result in increased CXCR4 protein levels, and scoring of CXCR4 immunostaining actually showed a decrease in staining intensity following CYP treatment.
Neg (not) Positive_regulation (increased) of CXCR4 protein
13) Confidence 0.46 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2588654 Disease Relevance 0.16 Pain Relevance 0.08
After the combination of gp120/hCD4 and ddC, there was an increase in the number of CXCR4 immunopositive neurons (35.1 ± 1.6%) (Fig. 5C, F, G).
Positive_regulation (increase) of CXCR4 in neurons
14) Confidence 0.42 Published 2009 Journal Mol Pain Section Body Doc Link PMC2734548 Disease Relevance 0.18 Pain Relevance 0.10
The behavioral effect of AMD3100 under the conditions of both injury induced CCR2 and CXCR4 functional signaling may be due to the possibility that chemokine receptors under these conditions may form homo- and heterodimers, which may ultimately alter their signaling properties.
Positive_regulation (induced) of CXCR4 associated with chemokine and injury
15) Confidence 0.42 Published 2009 Journal Mol Pain Section Body Doc Link PMC2734548 Disease Relevance 0.25 Pain Relevance 0.37
We previously demonstrated that the NRTI, 2'-3'-dideoxycytidine (ddC) not only produced mechanical hypernociceptive behavior but also upregulated CXCR4 mediated chemokine signaling in glia and neurons present in sensory ganglia.
Positive_regulation (upregulated) of CXCR4 in ganglia associated with chemokine
16) Confidence 0.39 Published 2009 Journal Mol Pain Section Body Doc Link PMC2734548 Disease Relevance 0.35 Pain Relevance 0.47
These studies indicate that the functional upregulation of CCR2 and CXCR4 signaling systems following a combination of gp120 and an NRTI are likely to be of central importance to associated DSP and may serve as potential therapeutic targets for treatment of this syndrome.



Positive_regulation (upregulation) of CXCR4 associated with neuropathy and syndrome
17) Confidence 0.39 Published 2009 Journal Mol Pain Section Abstract Doc Link PMC2734548 Disease Relevance 0.72 Pain Relevance 0.30
It was previously shown that NRTI treatment alone resulted in both increased mechanical hypersensitivity and upregulation of CXCR4/SDF1 signaling in the DRG [22].
Positive_regulation (upregulation) of CXCR4 associated with dorsal root ganglion and hypersensitivity
18) Confidence 0.39 Published 2009 Journal Mol Pain Section Body Doc Link PMC2734548 Disease Relevance 0.96 Pain Relevance 0.36
SDF-1 and its receptor CXCR4 are required for stem cells to home to the bone marrow.
Positive_regulation (required) of CXCR4 in bone marrow
19) Confidence 0.34 Published 2007 Journal The Open Cardiovascular Medicine Journal Section Body Doc Link PMC2570564 Disease Relevance 0.50 Pain Relevance 0.08
In the context of spinal cord injury, hypoxia inducible factor (HIF)-1 alpha activates numerous downstream effectors such as BDNF, VEGF, SDF-1, TrkB, Nrp-1, CXCR4 and NO, that attempt to restore the "neurovascular niche" after damage has occurred [43].
Positive_regulation (activates) of CXCR4 in spinal cord associated with hypoxia and spinal cord
20) Confidence 0.22 Published 2010 Journal Int Arch Med Section Body Doc Link PMC2989319 Disease Relevance 0.71 Pain Relevance 0.08

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox