INT14907

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Context Info
Confidence 0.40
First Reported 1990
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0.75
Pain Relevance 2.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Mbp)
Anatomy Link Frequency
urine 4
mesencephalic tectum 2
Mbp (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 16 100.00 Very High Very High Very High
antagonist 4 99.38 Very High Very High Very High
agonist 2 96.00 Very High Very High Very High
Pain 1 95.00 High High
Catecholamine 3 93.24 High High
Central grey 4 90.56 High High
Morphine 3 86.12 High High
Versed 5 85.60 High High
intrathecal 2 79.32 Quite High
dopamine receptor 6 78.64 Quite High
Disease Link Frequency Relevance Heat
Heart Rate Under Development 1 96.80 Very High Very High Very High
Shock 1 93.08 High High
Urological Neuroanatomy 4 90.56 High High
Diuresis 4 75.00 Quite High
Hypertension 2 36.12 Quite Low
Nociception 2 31.32 Quite Low
Unconsciousness 6 5.00 Very Low Very Low Very Low
Body Weight 2 5.00 Very Low Very Low Very Low
Diabetes Mellitus 1 5.00 Very Low Very Low Very Low
Cerebrovascular Disease 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Peripherally administered nicardipine or nimodipine blocked the increase in MBP associated with endotracheal intubation, but failed to block the increase in BIS, implying little indirect action on BIS through affecting hemodynamics or blocking movement of peripheral catecholamine.
Negative_regulation (blocked) of Positive_regulation (increase) of MBP associated with catecholamine
1) Confidence 0.40 Published 2010 Journal Korean Journal of Anesthesiology Section Body Doc Link PMC2966706 Disease Relevance 0 Pain Relevance 0.55
In contrast, pretreatment of cats with the nonselective alpha-adrenoceptor antagonist, phentolamine (1 mg/kg, i.v.) prevented dopamine-induced increases in urine output and MBP.
Negative_regulation (prevented) of Positive_regulation (increases) of MBP in urine associated with dopamine and antagonist
2) Confidence 0.10 Published 1991 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 1709232 Disease Relevance 0.15 Pain Relevance 0.58
Microinjection of both drugs attenuated the behavioral reaction and increases in MBP and HR induced by mesencephalic tectum stimulation, while attenuating only the increase in heart rate induced by peripheral painful stimulation.
Negative_regulation (attenuated) of Positive_regulation (increases) of MBP in mesencephalic tectum associated with pain and heart rate under development
3) Confidence 0.08 Published 1990 Journal Neurosci Biobehav Rev Section Abstract Doc Link 2287487 Disease Relevance 0.53 Pain Relevance 0.70
The increases in MBP, urine output, UNaV, and FENa induced by dopamine (10-100 micrograms/kg/min, i.v.), were unaffected by pretreatment of cats with either the selective dopamine DA1 or DA2 receptor antagonists, SCH 23390 (30 micrograms/kg, i.v.), or domperidone (100 micrograms/kg, i.v.) respectively.
Neg (unaffected) Negative_regulation (unaffected) of Positive_regulation (increases) of MBP in urine associated with dopamine and antagonist
4) Confidence 0.07 Published 1991 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 1709232 Disease Relevance 0.07 Pain Relevance 0.49

General Comments

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