INT149090

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Context Info
Confidence 0.70
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 2.33
Pain Relevance 1.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ghsr) plasma membrane (Ghsr) signal transducer activity (Ghsr)
Anatomy Link Frequency
neurons 1
Ghsr (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 70 94.36 High High
Somatostatin 33 93.96 High High
Dorsal horn 2 87.24 High High
tetrodotoxin 2 84.88 Quite High
agonist 12 83.56 Quite High
Action potential 30 80.64 Quite High
Spinal cord 3 76.08 Quite High
Pain 19 72.00 Quite High
IPN 1 71.16 Quite High
qutenza 2 66.64 Quite High
Disease Link Frequency Relevance Heat
Anorexia 3 95.52 Very High Very High Very High
Obesity 268 94.84 High High
Diabetes Mellitus 126 93.92 High High
Hyperglycemia 16 88.56 High High
Syndrome 264 86.32 High High
Insulin Resistance 72 80.72 Quite High
Hyperphagia 76 75.68 Quite High
Pain 22 72.00 Quite High
Inflammatory Pain 1 71.16 Quite High
Nociception 4 64.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Specificity of type 1a GHSR activation was confirmed by the lack of effect of the deacylated form of ghrelin (des-acyl-ghrelin) and after preincubation with the specific receptor antagonist [d-Lys(3)]GHRP-6.
Positive_regulation (activation) of GHSR associated with antagonist
1) Confidence 0.70 Published 2008 Journal Endocrinology Section Abstract Doc Link 18202139 Disease Relevance 0.21 Pain Relevance 0.59
Hence, it is likely that GHSR activation mediates the enhancement of the electrical activity of GHRH neurons induced by ghrelin and the GHS tested in this study.
Positive_regulation (activation) of GHSR in neurons
2) Confidence 0.62 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2820089 Disease Relevance 0 Pain Relevance 0.19
No specific immunocytochemical signal was detected in the ghrelin, GHSR or GOAT null mice with our antibodies raised against these respective proteins, suggesting that the antibodies were indeed specific.
Positive_regulation (detected) of GHSR
3) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2939079 Disease Relevance 0 Pain Relevance 0
Ghrelin acylation is considered necessary for its actions via GHSR1a, such as its strong GH-releasing activity [9, 18–20].
Positive_regulation (necessary) of GHSR1a
4) Confidence 0.41 Published 2010 Journal International Journal of Peptides Section Body Doc Link PMC2911604 Disease Relevance 0 Pain Relevance 0
All these data suggest that the direct effects of ghrelin on insulin-stimulated glucose uptake are mediated by the GHSR1a and PI3K/AKT activation.


Positive_regulation (activation) of GHSR1a
5) Confidence 0.38 Published 2010 Journal International Journal of Peptides Section Body Doc Link PMC2911604 Disease Relevance 0.81 Pain Relevance 0
Effect of Ghrelin on Glucose-Insulin Homeostasis: Therapeutic Implications

Ghrelin is a 28-amino-acid peptide that displays a strong growth hormone- (GH-) releasing activity through the activation of the growth hormone secretagogue receptor (GHSR).

Positive_regulation (activation) of GHSR
6) Confidence 0.38 Published 2010 Journal International Journal of Peptides Section Title Doc Link PMC2911604 Disease Relevance 0.07 Pain Relevance 0
Effect of Ghrelin on Glucose-Insulin Homeostasis: Therapeutic Implications

Ghrelin is a 28-amino-acid peptide that displays a strong growth hormone- (GH-) releasing activity through the activation of the growth hormone secretagogue receptor (GHSR).

Positive_regulation (activation) of secretagogue receptor
7) Confidence 0.34 Published 2010 Journal International Journal of Peptides Section Title Doc Link PMC2911604 Disease Relevance 0.07 Pain Relevance 0
Future work crossing Snord116del mice with ghrelin-null mice and mice lacking the ghrelin receptor (also called growth hormone secretagogue receptor, GHS-R, GeneID: 208188) may define the role of ghrelin in the phenotype of Snord116del mice.


Positive_regulation (called) of growth hormone secretagogue receptor
8) Confidence 0.30 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2248623 Disease Relevance 0.39 Pain Relevance 0.09
Future work crossing Snord116del mice with ghrelin-null mice and mice lacking the ghrelin receptor (also called growth hormone secretagogue receptor, GHS-R, GeneID: 208188) may define the role of ghrelin in the phenotype of Snord116del mice.


Positive_regulation (called) of ghrelin receptor
9) Confidence 0.30 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2248623 Disease Relevance 0.39 Pain Relevance 0.09
Future work crossing Snord116del mice with ghrelin-null mice and mice lacking the ghrelin receptor (also called growth hormone secretagogue receptor, GHS-R, GeneID: 208188) may define the role of ghrelin in the phenotype of Snord116del mice.


Positive_regulation (called) of GHS-R
10) Confidence 0.30 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2248623 Disease Relevance 0.39 Pain Relevance 0.09

General Comments

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