INT1491

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Context Info
Confidence 0.53
First Reported 1977
Last Reported 2009
Negated 6
Speculated 2
Reported most in Abstract
Documents 33
Total Number 35
Disease Relevance 5.17
Pain Relevance 13.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Rtcd1) molecular_function (Rtcd1) ligase activity (Rtcd1)
Anatomy Link Frequency
NG108-15 2
esophageal sphincter 2
reticular formation 1
brain 1
forebrain 1
Rtcd1 (Mus musculus)
Pain Link Frequency Relevance Heat
opiate 35 100.00 Very High Very High Very High
opioid receptor 6 100.00 Very High Very High Very High
Enkephalin 17 99.98 Very High Very High Very High
noradrenaline 14 99.84 Very High Very High Very High
lidocaine 1 99.84 Very High Very High Very High
Immobilon 12 99.72 Very High Very High Very High
Morphine 40 99.68 Very High Very High Very High
Opioid 7 99.44 Very High Very High Very High
mu opioid receptor 5 99.44 Very High Very High Very High
Nicotine 6 99.24 Very High Very High Very High
Disease Link Frequency Relevance Heat
Neuroblastoma 9 99.56 Very High Very High Very High
Aggression 6 99.42 Very High Very High Very High
Nicotine Addiction 4 99.36 Very High Very High Very High
Glioma 8 98.92 Very High Very High Very High
Pain 39 98.74 Very High Very High Very High
Hypotension 4 98.28 Very High Very High Very High
Nociception 23 98.08 Very High Very High Very High
Bordatella Infection 9 97.56 Very High Very High Very High
Opiate Addiction 5 93.48 High High
Vibrio Infection 2 93.44 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is suggested that the inhibitory effects of SG on clonidine-induced aggressive behavior are realized mainly via its effect on adenylate cyclase and perhaps involving synaptic transmitter action.
Regulation (effect) of cyclase associated with aggression and clonidine
1) Confidence 0.53 Published 1989 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 2623007 Disease Relevance 0.27 Pain Relevance 0.35
The point at which the dependencies on normorphine, clonidine, and adenosine converge is probably below their separate recognition sites and is possibly at the level of adenylate cyclase regulation.
Regulation (regulation) of cyclase associated with adenocard and clonidine
2) Confidence 0.48 Published 1984 Journal NIDA Res. Monogr. Section Abstract Doc Link 6085397 Disease Relevance 0.14 Pain Relevance 0.82
The effects of a reversible activator of adenylate cyclase sclareol glycol (SG), a semisynthetic diterpene of the labdane family, on the aggressive behavior induced by a high dose of clonidine in mice were studied.
Regulation (effects) of cyclase associated with aggression and clonidine
3) Confidence 0.39 Published 1989 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 2623007 Disease Relevance 0.24 Pain Relevance 0.31
Sensitivity of the NA-stimulated adenylate cyclase was not altered by chronic treatment with FLA-63 alone as a 0.05% diet.
Neg (not) Regulation (altered) of cyclase associated with noradrenaline
4) Confidence 0.34 Published 1977 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 909612 Disease Relevance 0 Pain Relevance 0.59
Methylene blue, a guanylate cyclase inhibitor, was not able to antagonize the hypotensive activity of melatonin, suggesting that the mechanism of action of melatonin does not involve guanylate cyclase.
Neg (not) Regulation (involve) of cyclase associated with hypotension
5) Confidence 0.33 Published 2000 Journal Pharmacol. Toxicol. Section Abstract Doc Link 10752670 Disease Relevance 0.32 Pain Relevance 0.18
Neither the nitric oxide synthesis inhibitor N(omega)-nitro-L-arginine methyl ester (L-NAME; 10 microM) nor the soluble guanylate cyclase inhibitor ODQ (10 microM) significantly affected the Catuama-induced relaxations.
Neg (nor) Regulation (affected) of cyclase
6) Confidence 0.29 Published 2001 Journal Phytother Res Section Abstract Doc Link 11507734 Disease Relevance 0 Pain Relevance 0.13
The same factors that regulate the activation of purified hepatic soluble guanylate cyclase by diverse agents possessing distinct requirements for enzyme activation were found to modulate cyclic GMP formation in intact viable hepatic cells.
Regulation (regulate) of cyclase
7) Confidence 0.21 Published 1987 Journal J. Biol. Chem. Section Abstract Doc Link 2435723 Disease Relevance 0 Pain Relevance 0
The markers used to evaluate RPC differentiation included the early photoreceptor marker CRX, the bipolar cell marker PKC, the neural progenitor marker nestin, the active cell cycle marker Ki67, the mature photoreceptor marker 4D2, the glial cell marker GFAP, the photoreceptor marker recoverin, and the neural filament maker nf-200.
Regulation (differentiation) of RPC in glial cell
8) Confidence 0.16 Published 2008 Journal J Ocul Biol Dis Infor Section Body Doc Link PMC2802414 Disease Relevance 0 Pain Relevance 0
Following these treatments, alterations in the sensitivity of limbic forebrain adenylate cyclase to noradrenaline (NA), and in the locomotor response of the mice to dopaminergic and noradrenergic agonists were studied.
Regulation (alterations) of cyclase in forebrain associated with agonist and noradrenaline
9) Confidence 0.15 Published 1977 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 909612 Disease Relevance 0 Pain Relevance 0.30
Developmental expression of G proteins that differentially modulate adenylyl cyclase activity in mouse brain.
Regulation (modulate) of cyclase in brain associated with immobilon
10) Confidence 0.11 Published 1991 Journal FEBS Lett. Section Title Doc Link 1652479 Disease Relevance 0 Pain Relevance 0.13
On the basis of our data two suggestions are made: (i) there are opiate receptors on lymphocytes with a mechanism of action connected with the regulation of adenylate cyclase activity; (ii) smoking develops tolerance to morphine at the level of the opiate-dependent adenylate cyclase of lymphocytes.
Regulation (regulation) of cyclase in lymphocytes associated with nicotine addiction, tolerance, opiate and morphine
11) Confidence 0.10 Published 1983 Journal Biol. Psychiatry Section Abstract Doc Link 6311291 Disease Relevance 0.34 Pain Relevance 0.84
The effects of pertussis toxin, forskolin, and cAMP analogues on the antinociceptive action of nicotine were examined to investigate the possible involvement of adenylate cyclase and G-proteins in nicotine's antinociceptive effect.
Spec (possible) Regulation (involvement) of cyclase associated with bordatella infection, nicotine and antinociceptive
12) Confidence 0.09 Published 1994 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 8029303 Disease Relevance 0.19 Pain Relevance 0.64
On the other hand, the changes in adenylate cyclase and cyclic AMP dependent protein kinase activities were not affected significantly by levallorphan administration.
Regulation (changes) of cyclase
13) Confidence 0.05 Published 1978 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 206752 Disease Relevance 0.08 Pain Relevance 0.71
Therefore, an additional series of studies quantified the effects of a soluble guanylate cyclase (sGC) inhibitor, 1H-[1,2,4]oxadiazolo-[4,3-a]quinoxalin-1-one (ODQ), on ACh release in the cat medial pontine reticular formation.
Regulation (effects) of cyclase in reticular formation
14) Confidence 0.05 Published 2006 Journal J. Appl. Physiol. Section Abstract Doc Link 16424074 Disease Relevance 0 Pain Relevance 0.24
Neuroblastoma X glioma NG108-15 hybrid cells cultured in a serum-free chemically defined medium: effects on acute and chronic opiate regulation of adenylate cyclase activity.
Regulation (regulation) of cyclase in NG108-15 associated with opiate, glioma and immobilon
15) Confidence 0.04 Published 1985 Journal Brain Res. Section Title Doc Link 3000535 Disease Relevance 0.39 Pain Relevance 0.34
Muscarinic receptor regulation of NG108-15 adenylate cyclase: requirement for Na+ and GTP.
Regulation (regulation) of cyclase in NG108-15
16) Confidence 0.03 Published 1979 Journal J Cyclic Nucleotide Res Section Title Doc Link 521545 Disease Relevance 0.19 Pain Relevance 0.15
These cell lines provide an excellent model system for studying the regulation of opioid receptor-adenylyl cyclase coupling efficiency.
Regulation (regulation) of cyclase associated with opioid receptor
17) Confidence 0.03 Published 1995 Journal Biochem. Pharmacol. Section Abstract Doc Link 7840787 Disease Relevance 0.07 Pain Relevance 0.22
Modifications in the properties of Gs or Go,i proteins were postulated because the number of adenylate cyclase catalytic subunits was not affected by 17 beta-oestradiol pretreatment.
Neg (not) Regulation (affected) of cyclase
18) Confidence 0.03 Published 1990 Journal Ciba Found. Symp. Section Abstract Doc Link 1963397 Disease Relevance 0.25 Pain Relevance 0.26
On the other hand, the changes in adenylate cyclase and cyclic AMP dependent protein kinase activities were not affected significantly by levallorphan administration.
Neg (not) Regulation (affected) of cyclase
19) Confidence 0.02 Published 1978 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 206752 Disease Relevance 0.08 Pain Relevance 0.72
The acute and chronic effects of opiates on adenylate cyclase were similar for cells grown under either set of conditions.
Regulation (effects) of cyclase associated with opiate
20) Confidence 0.02 Published 1985 Journal Brain Res. Section Abstract Doc Link 3000535 Disease Relevance 0.30 Pain Relevance 0.31

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