INT149125

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Context Info
Confidence 0.78
First Reported 2007
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 25
Total Number 27
Disease Relevance 3.45
Pain Relevance 2.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Slc4a3) plasma membrane (Slc4a3)
Anatomy Link Frequency
ganglion cell layer 5
neuronal 3
glial cells 2
respiratory 2
central nervous system 1
Slc4a3 (Mus musculus)
Pain Link Frequency Relevance Heat
Central nervous system 66 99.96 Very High Very High Very High
isoflurane 12 98.32 Very High Very High Very High
anesthesia 53 96.28 Very High Very High Very High
palliative 2 82.44 Quite High
depression 66 58.84 Quite High
Inflammation 4 27.36 Quite Low
ketamine 44 5.00 Very Low Very Low Very Low
imagery 44 5.00 Very Low Very Low Very Low
Calcium channel 44 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 69 96.88 Very High Very High Very High
Cancer 190 96.40 Very High Very High Very High
Blindness 88 94.60 High High
Retina Disease 66 93.20 High High
Metastasis 60 92.48 High High
Ganglion Cysts 44 90.28 High High
Congenital Anomalies 110 89.76 High High
Hypercapnia 3 89.56 High High
Recurrence 8 77.60 Quite High
Growth Problems 22 77.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Here we examined the effect of AE3 expression on respiratory rate (RR) in vivo.
Gene_expression (expression) of AE3 in respiratory
1) Confidence 0.78 Published 2007 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 18204149 Disease Relevance 0.16 Pain Relevance 0.30
Results show that AE3 expression profoundly influences control of breathing in mice.
Gene_expression (expression) of AE3
2) Confidence 0.78 Published 2007 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 18204149 Disease Relevance 0.16 Pain Relevance 0.42
In the central nervous system, neuronal and glial brain cells express only AE3fl isoform.
Gene_expression (express) of AE3fl in neuronal associated with central nervous system
3) Confidence 0.78 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1950688 Disease Relevance 0 Pain Relevance 0.14
Conversely, the inner retina, which is also part of the central nervous system, expresses both AE3fl and AE3c isoforms, in neuronal and glial cells [10].
Gene_expression (expresses) of AE3fl in glial cells associated with central nervous system
4) Confidence 0.78 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1950688 Disease Relevance 0 Pain Relevance 0.14
Conversely, the inner retina, which is also part of the central nervous system, expresses both AE3fl and AE3c isoforms, in neuronal and glial cells [10].
Gene_expression (expresses) of AE3c in glial cells associated with central nervous system
5) Confidence 0.78 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1950688 Disease Relevance 0 Pain Relevance 0.14
AE1/AE3 produced weak to moderate staining and Vimentin was positive in ~90% cells in the sarcomatoid component of the primary tumor.
Gene_expression (produced) of AE3 associated with cancer
6) Confidence 0.75 Published 2010 Journal BMC Clin Pathol Section Body Doc Link PMC2829523 Disease Relevance 0.90 Pain Relevance 0.08
The predicted cardiac AE3 (AE3c) polypeptide is 1030 amino acids in length and approximately 120 kDa, while the AE3fl variant consists of 1227 amino acids and ?
Gene_expression (The) of AE3
7) Confidence 0.68 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1950688 Disease Relevance 0.05 Pain Relevance 0.06
The predicted cardiac AE3 (AE3c) polypeptide is 1030 amino acids in length and approximately 120 kDa, while the AE3fl variant consists of 1227 amino acids and ?
Gene_expression (The) of AE3c
8) Confidence 0.68 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1950688 Disease Relevance 0.05 Pain Relevance 0.06
The predicted cardiac AE3 (AE3c) polypeptide is 1030 amino acids in length and approximately 120 kDa, while the AE3fl variant consists of 1227 amino acids and ?
Gene_expression (predicted) of AE3c
9) Confidence 0.68 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1950688 Disease Relevance 0.05 Pain Relevance 0.06
The AE3-mediated HCO3?
Gene_expression (The) of AE3
10) Confidence 0.68 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1950688 Disease Relevance 0 Pain Relevance 0
Our results provide compelling evidence linking AE3 Cl?
Gene_expression (linking) of AE3
11) Confidence 0.68 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1950688 Disease Relevance 0.71 Pain Relevance 0
The predicted cardiac AE3 (AE3c) polypeptide is 1030 amino acids in length and approximately 120 kDa, while the AE3fl variant consists of 1227 amino acids and ?
Gene_expression (predicted) of AE3
12) Confidence 0.68 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1950688 Disease Relevance 0.05 Pain Relevance 0.06
The predicted cardiac AE3 (AE3c) polypeptide is 1030 amino acids in length and approximately 120 kDa, while the AE3fl variant consists of 1227 amino acids and ?
Gene_expression (variant) of AE3fl
13) Confidence 0.68 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1950688 Disease Relevance 0 Pain Relevance 0.07
E12 (M0630, 1:100, 1 hr; Dako, Mississauga, ON), mouse monoclonal Vimentin (Vim3B4, 1:200, 1 hr; American Research Products, Belmont, MA), mouse monoclonal E-cadherin (36B5, 1:100, overnight; Vector Labs, Burlington, ON), mouse monoclonal p63(7JUL, 1:50, 2 hrs; Vector Labs) and human cytokeratin cocktail (AE1/AE3, 1:200, 1 hr; Dako).
Gene_expression (/) of AE3
14) Confidence 0.65 Published 2010 Journal BMC Clin Pathol Section Body Doc Link PMC2829523 Disease Relevance 0 Pain Relevance 0
Generation and genotyping of Slc4a3?
Gene_expression (Generation) of Slc4a3
15) Confidence 0.60 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1950688 Disease Relevance 0.13 Pain Relevance 0
Immunoblots revealed that AE3 was expressed only in Slc4a3+/+ Slc4a3+/?
Gene_expression (expressed) of AE3
16) Confidence 0.60 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1950688 Disease Relevance 0.45 Pain Relevance 0
Confocal immunofluorescence (Fig. 3a–d) confirmed the expression of the two alternate AE3 forms [10], AE3 cardiac (AE3c), and AE3 full length (AE3fl), respectively in horizontal cells [somas in inner nuclear layer (INL) and processes in outer plexiform layer (OPL)], Müller cells (somas and processes in the inner nuclear layer, and processes in the inner plexiform layer), and somas in the ganglion cell layer of Slc4a3+/+ but not Slc4a3?
Gene_expression (expression) of AE3c in ganglion cell layer associated with ganglion cysts
17) Confidence 0.60 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1950688 Disease Relevance 0.09 Pain Relevance 0
Confocal immunofluorescence (Fig. 3a–d) confirmed the expression of the two alternate AE3 forms [10], AE3 cardiac (AE3c), and AE3 full length (AE3fl), respectively in horizontal cells [somas in inner nuclear layer (INL) and processes in outer plexiform layer (OPL)], Müller cells (somas and processes in the inner nuclear layer, and processes in the inner plexiform layer), and somas in the ganglion cell layer of Slc4a3+/+ but not Slc4a3?
Gene_expression (expression) of AE3fl in ganglion cell layer associated with ganglion cysts
18) Confidence 0.60 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1950688 Disease Relevance 0.09 Pain Relevance 0
Confocal immunofluorescence (Fig. 3a–d) confirmed the expression of the two alternate AE3 forms [10], AE3 cardiac (AE3c), and AE3 full length (AE3fl), respectively in horizontal cells [somas in inner nuclear layer (INL) and processes in outer plexiform layer (OPL)], Müller cells (somas and processes in the inner nuclear layer, and processes in the inner plexiform layer), and somas in the ganglion cell layer of Slc4a3+/+ but not Slc4a3?
Gene_expression (expression) of AE3 in ganglion cell layer associated with ganglion cysts
19) Confidence 0.60 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1950688 Disease Relevance 0.09 Pain Relevance 0
Therefore, we examined the expression of CAII (whole lysate), and CAXIV and NBC1 (membrane) cellular fractions of freshly isolated Slc4a3?
Spec (examined) Gene_expression (expression) of Slc4a3
20) Confidence 0.60 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1950688 Disease Relevance 0.06 Pain Relevance 0.03

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