INT14914

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Context Info
Confidence 0.52
First Reported 1991
Last Reported 2010
Negated 4
Speculated 1
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 4.59
Pain Relevance 1.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (Cdh5) plasma membrane (Cdh5)
Anatomy Link Frequency
endothelial cell 2
Cdh5 (Mus musculus)
Pain Link Frequency Relevance Heat
depression 12 99.76 Very High Very High Very High
tetrodotoxin 8 99.12 Very High Very High Very High
imagery 37 98.98 Very High Very High Very High
Inflammation 8 95.12 Very High Very High Very High
anesthesia 3 67.36 Quite High
cva 2 56.60 Quite High
positron emission tomography 13 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
chemokine 1 5.00 Very Low Very Low Very Low
isoflurane 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Coronary Artery Disease 31 100.00 Very High Very High Very High
Shock 6 100.00 Very High Very High Very High
Depression 12 99.76 Very High Very High Very High
Hypoxia 12 96.86 Very High Very High Very High
INFLAMMATION 8 95.12 Very High Very High Very High
Adhesions 6 94.72 High High
Hemorrhagic Shock 18 92.44 High High
Leukemia 1 81.12 Quite High
Hemorrhage 2 56.60 Quite High
Cancer 114 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Endothelial genes CD31 and VE-cadherin, which function in endothelial cell homeostasis and integrity, were not affected during the shock phase except for VE-cadherin in the liver, which showed increased mRNA levels.
Neg (not) Regulation (affected) of VE-cadherin in endothelial cell associated with shock
1) Confidence 0.52 Published 2008 Journal Shock Section Abstract Doc Link 17704730 Disease Relevance 1.52 Pain Relevance 0.26
Endothelial genes CD31 and VE-cadherin, which function in endothelial cell homeostasis and integrity, were not affected during the shock phase except for VE-cadherin in the liver, which showed increased mRNA levels.
Neg (not) Regulation (affected) of VE-cadherin in endothelial cell associated with shock
2) Confidence 0.38 Published 2008 Journal Shock Section Abstract Doc Link 17704730 Disease Relevance 1.48 Pain Relevance 0.25
Three-dimensional fluorescent-mediated tomography imaging study to assess the PK of E4G10 and determine the number of VE-cad monomer epitopes per cell in vivo
Spec (determine) Regulation (number) of VE-cad associated with coronary artery disease and imagery
3) Confidence 0.29 Published 2010 Journal Int J Nanomedicine Section Body Doc Link PMC2962274 Disease Relevance 0.18 Pain Relevance 0.07
In most slices, TTX (1 microM) increased SD latency but had no effect on the Vec shift.
Neg (no) Regulation (effect) of Vec associated with tetrodotoxin and depression
4) Confidence 0.23 Published 1991 Journal Brain Res. Section Abstract Doc Link 1709386 Disease Relevance 0.69 Pain Relevance 0.63
TEA (10 mM) decreased the latency of hypoxia-induced spreading depression (SD), and reduced the amplitudes of the changes in Vec and [K+]o. 4-AP (50 microM) also decreased the latency of SD but had no effect on the Vec shift.
Neg (no) Regulation (effect) of Vec associated with depression and hypoxia
5) Confidence 0.23 Published 1991 Journal Brain Res. Section Abstract Doc Link 1709386 Disease Relevance 0.72 Pain Relevance 0.63

General Comments

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