INT149144

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Context Info
Confidence 0.46
First Reported 2007
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 20
Disease Relevance 34.27
Pain Relevance 1.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
blood 7
aorta 3
tube 2
artery 2
vascular system 1
Ang2 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 279 100.00 Very High Very High Very High
cytokine 257 100.00 Very High Very High Very High
Enkephalin 6 97.22 Very High Very High Very High
Endogenous opioid 3 85.16 High High
alcohol 16 74.56 Quite High
Pain 17 27.76 Quite Low
anesthesia 32 25.76 Quite Low
Inflammatory response 33 5.00 Very Low Very Low Very Low
cINOD 19 5.00 Very Low Very Low Very Low
chemokine 16 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 315 100.00 Very High Very High Very High
Cytomegalovirus Infection 3072 99.84 Very High Very High Very High
Infection 2208 99.82 Very High Very High Very High
Pressure And Volume Under Development 944 98.88 Very High Very High Very High
Hypertrophy 3 98.78 Very High Very High Very High
Weight Gain 48 97.82 Very High Very High Very High
Increased Venous Pressure Under Development 64 96.20 Very High Very High Very High
Atherosclerosis 465 95.84 Very High Very High Very High
Atherosclerotic Plaque 96 94.88 High High
Colon Cancer 7 86.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Consistent with the marked reduction in mammary vasculature in Cox-2 null mammary tissues, the expression of several angiogenesis-associated genes was decreased (Figure 5b), including VEGF (which encodes vascular endothelial growth factor), Ang1 and Ang2 (which encode Tie-2 ligands), and Flk-1 and Flt-1 (which encode vascular endothelial growth factor receptors).
Gene_expression (expression) of Ang2 in vasculature
1) Confidence 0.46 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2206709 Disease Relevance 0.56 Pain Relevance 0
The goal of this investigation was to examine how cardiac levels of enkephalin production are altered in the development of normotensive primary hypertrophy due to elevated intra-cardiac angiotensin II (Ang II) production.
Gene_expression (production) of Ang II associated with hypertrophy and enkephalin
2) Confidence 0.38 Published 2007 Journal J Renin Angiotensin Aldosterone Syst Section Abstract Doc Link 18205093 Disease Relevance 0.10 Pain Relevance 0.26
The TG1306/1R exhibit cardiac specific Ang II overexpression and cardiac hypertrophy, but not hypertension.
Gene_expression (overexpression) of Ang II
3) Confidence 0.38 Published 2007 Journal J Renin Angiotensin Aldosterone Syst Section Body Doc Link 18205093 Disease Relevance 0.09 Pain Relevance 0
CONCLUSIONS: We have provided evidence that a marked elevation of myocardial enkephalin level is observed in the established (but not early) phase of cardiac hypertrophy associated with cardiac-specific Ang II-overexpression.
Gene_expression (overexpression) of Ang II
4) Confidence 0.30 Published 2007 Journal J Renin Angiotensin Aldosterone Syst Section Body Doc Link 18205093 Disease Relevance 0.06 Pain Relevance 0
Thus, CMV infection did not contribute to the mouse weight gain, but caused an increase of blood pressure apparently via a change in expression of cellular genes, the over expression of inflammatory cytokines, renin and Ang II in the vascular system.
Gene_expression (expression) of Ang II in vascular system associated with pressure and volume under development, inflammation, cytomegalovirus infection, weight gain, infection and cytokine
5) Confidence 0.09 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2673691 Disease Relevance 1.99 Pain Relevance 0.10
After centrifugation, the supernatant of cell lysate was collected from each tube and then used for detection of Ang II by ELISA.


Gene_expression (detection) of Ang II in tube
6) Confidence 0.09 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2673691 Disease Relevance 0.22 Pain Relevance 0.04
To determine whether MCMV infection also changed expression of Ang II, we examined Ang II levels in mouse serum and in artery tissues.
Gene_expression (expression) of Ang II in artery associated with cytomegalovirus infection and infection
7) Confidence 0.09 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2673691 Disease Relevance 2.13 Pain Relevance 0
Despite a high basal level of Ang II expression in artery tissues, MCMV infection alone increased expression of Ang II in aorta samples and also exaggerated an increased expression of Ang II induced by high cholesterol diet (Fig. 5B).
Gene_expression (expression) of Ang II in aorta associated with cytomegalovirus infection and infection
8) Confidence 0.09 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2673691 Disease Relevance 2.24 Pain Relevance 0.03
For detection of Ang II in vessel samples, 0.2 inch of aorta fragment of 3 randomly selected mice from each group were diced and put in a 2-ml tube with 470 ┬Ál of lysis buffer, respectively (20 mM HEPES, pH 7.5, 150 mM NaCl, 1% Triton X-100, 0.1% SDS, 1 mM EDTA, 1 mM DTT, 2 tablets of Roche protease inhibitor/50 ml).
Gene_expression (detection) of Ang II in tube
9) Confidence 0.09 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2673691 Disease Relevance 0.38 Pain Relevance 0
Despite a high basal level of Ang II expression in artery tissues, MCMV infection alone increased expression of Ang II in aorta samples and also exaggerated an increased expression of Ang II induced by high cholesterol diet (Fig. 5B).
Gene_expression (expression) of Ang II in aorta associated with cytomegalovirus infection and infection
10) Confidence 0.09 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2673691 Disease Relevance 2.17 Pain Relevance 0.03
MCMV infection induced expression of Ang II in mouse blood and artery tissues
Gene_expression (expression) of Ang II in artery associated with cytomegalovirus infection and infection
11) Confidence 0.09 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2673691 Disease Relevance 2.32 Pain Relevance 0
Despite a high basal level of Ang II expression in artery tissues, MCMV infection alone increased expression of Ang II in aorta samples and also exaggerated an increased expression of Ang II induced by high cholesterol diet (Fig. 5B).
Gene_expression (expression) of Ang II in aorta associated with cytomegalovirus infection and infection
12) Confidence 0.09 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2673691 Disease Relevance 2.26 Pain Relevance 0.03
These results suggest that CMV infection induced renin and Ang II expression, and this underlies a molecular mechanism by which CMV infection causes an increase of blood pressure.


Gene_expression (expression) of Ang II in blood associated with pressure and volume under development, cytomegalovirus infection and infection
13) Confidence 0.09 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2673691 Disease Relevance 2.28 Pain Relevance 0.04
Further examination of angiotensin-II (Ang II) in mouse serum and arterial tissues with ELISA showed an increased expression of Ang II by MCMV infection.
Gene_expression (expression) of Ang II associated with cytomegalovirus infection and infection
14) Confidence 0.09 Published 2009 Journal PLoS Pathogens Section Abstract Doc Link PMC2673691 Disease Relevance 2.31 Pain Relevance 0.08
Expression of viral genes and viral persistent infection of blood vessel endothelial cells resulting in an increased expression of inflammatory cytokines, including renin and Ang II, may underpin the molecular mechanism by which CMV infection induces an increase in blood pressure.



Gene_expression (expression) of Ang II in blood associated with pressure and volume under development, inflammation, cytomegalovirus infection, infection and cytokine
15) Confidence 0.07 Published 2009 Journal PLoS Pathogens Section Abstract Doc Link PMC2673691 Disease Relevance 2.50 Pain Relevance 0.10
Enhanced expression of pro-inflammatory cytokines, renin and Ang II underlies the pathogenic mechanism of an active CMV infection to increase blood pressure and aggravate atherosclerosis.
Gene_expression (expression) of Ang II in blood associated with inflammation, atherosclerosis, cytomegalovirus infection, infection and cytokine
16) Confidence 0.07 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2673691 Disease Relevance 2.91 Pain Relevance 0.10
An increased expression of renin and Ang II has been known to cause an increase in blood pressure or hypertension in humans.
Gene_expression (expression) of Ang II in blood associated with pressure and volume under development
17) Confidence 0.07 Published 2009 Journal PLoS Pathogens Section Abstract Doc Link PMC2673691 Disease Relevance 2.64 Pain Relevance 0.08
These results support that CMV infection of blood vessel cells and expression of viral RNA and DNA played an important role in inducing the increase of blood pressure, potentially by altering expression of host cell genes that are involved in expression of pro-inflammatory cytokines, renin and Ang II, affecting vessel cell function and resulting in an increase of blood pressure.


Gene_expression (expression) of Ang II in blood associated with pressure and volume under development, inflammation, cytomegalovirus infection, infection and cytokine
18) Confidence 0.07 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2673691 Disease Relevance 2.04 Pain Relevance 0.10
Further studies show that CMV infection induces renin and angiotensin II (Ang II) expression in blood and in vessel cells, in a persistent infection manner.
Gene_expression (expression) of Ang II in blood associated with cytomegalovirus infection and infection
19) Confidence 0.07 Published 2009 Journal PLoS Pathogens Section Abstract Doc Link PMC2673691 Disease Relevance 2.76 Pain Relevance 0.07
MCMV infection induced expression of Ang II in mouse blood and artery tissues
Gene_expression (expression) of Ang II in blood associated with cytomegalovirus infection and infection
20) Confidence 0.03 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2673691 Disease Relevance 2.32 Pain Relevance 0

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