INT149145

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Context Info
Confidence 0.34
First Reported 2007
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 15
Disease Relevance 27.89
Pain Relevance 0.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
aorta 8
blood 7
artery 5
vascular system 2
Ang2 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 204 100.00 Very High Very High Very High
cytokine 192 100.00 Very High Very High Very High
Enkephalin 6 98.00 Very High Very High Very High
Endogenous opioid 3 86.72 High High
Pain 12 31.88 Quite Low
anesthesia 24 29.88 Quite Low
Inflammatory response 24 5.00 Very Low Very Low Very Low
alcohol 12 5.00 Very Low Very Low Very Low
chemokine 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cytomegalovirus Infection 2304 100.00 Very High Very High Very High
Infection 1656 100.00 Very High Very High Very High
Pressure And Volume Under Development 708 100.00 Very High Very High Very High
INFLAMMATION 228 100.00 Very High Very High Very High
Weight Gain 36 99.88 Very High Very High Very High
Hypertrophy 3 99.56 Very High Very High Very High
Increased Venous Pressure Under Development 48 96.52 Very High Very High Very High
Atherosclerotic Plaque 72 91.44 High High
Atherosclerosis 348 86.96 High High
Injury 12 86.44 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The goal of this investigation was to examine how cardiac levels of enkephalin production are altered in the development of normotensive primary hypertrophy due to elevated intra-cardiac angiotensin II (Ang II) production.
Positive_regulation (elevated) of Gene_expression (production) of Ang II associated with hypertrophy and enkephalin
1) Confidence 0.34 Published 2007 Journal J Renin Angiotensin Aldosterone Syst Section Abstract Doc Link 18205093 Disease Relevance 0.10 Pain Relevance 0.26
The TG1306/1R exhibit cardiac specific Ang II overexpression and cardiac hypertrophy, but not hypertension.
Positive_regulation (overexpression) of Gene_expression (overexpression) of Ang II
2) Confidence 0.25 Published 2007 Journal J Renin Angiotensin Aldosterone Syst Section Body Doc Link 18205093 Disease Relevance 0.09 Pain Relevance 0
CONCLUSIONS: We have provided evidence that a marked elevation of myocardial enkephalin level is observed in the established (but not early) phase of cardiac hypertrophy associated with cardiac-specific Ang II-overexpression.
Positive_regulation (overexpression) of Gene_expression (overexpression) of Ang II
3) Confidence 0.23 Published 2007 Journal J Renin Angiotensin Aldosterone Syst Section Body Doc Link 18205093 Disease Relevance 0.06 Pain Relevance 0
Further examination of angiotensin-II (Ang II) in mouse serum and arterial tissues with ELISA showed an increased expression of Ang II by MCMV infection.
Positive_regulation (increased) of Gene_expression (expression) of Ang II associated with cytomegalovirus infection and infection
4) Confidence 0.08 Published 2009 Journal PLoS Pathogens Section Abstract Doc Link PMC2673691 Disease Relevance 2.32 Pain Relevance 0.08
Despite a high basal level of Ang II expression in artery tissues, MCMV infection alone increased expression of Ang II in aorta samples and also exaggerated an increased expression of Ang II induced by high cholesterol diet (Fig. 5B).
Positive_regulation (increased) of Gene_expression (expression) of Ang II in aorta associated with cytomegalovirus infection and infection
5) Confidence 0.08 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2673691 Disease Relevance 2.25 Pain Relevance 0.03
Thus, CMV infection did not contribute to the mouse weight gain, but caused an increase of blood pressure apparently via a change in expression of cellular genes, the over expression of inflammatory cytokines, renin and Ang II in the vascular system.
Positive_regulation (caused) of Gene_expression (expression) of Ang II in vascular system associated with pressure and volume under development, inflammation, cytomegalovirus infection, weight gain, infection and cytokine
6) Confidence 0.08 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2673691 Disease Relevance 2.11 Pain Relevance 0.10
MCMV infection induced expression of Ang II in mouse blood and artery tissues
Positive_regulation (induced) of Gene_expression (expression) of Ang II in artery associated with cytomegalovirus infection and infection
7) Confidence 0.08 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2673691 Disease Relevance 2.33 Pain Relevance 0
Despite a high basal level of Ang II expression in artery tissues, MCMV infection alone increased expression of Ang II in aorta samples and also exaggerated an increased expression of Ang II induced by high cholesterol diet (Fig. 5B).
Positive_regulation (increased) of Gene_expression (expression) of Ang II in aorta associated with cytomegalovirus infection and infection
8) Confidence 0.08 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2673691 Disease Relevance 2.18 Pain Relevance 0.03
Despite a high basal level of Ang II expression in artery tissues, MCMV infection alone increased expression of Ang II in aorta samples and also exaggerated an increased expression of Ang II induced by high cholesterol diet (Fig. 5B).
Positive_regulation (increased) of Gene_expression (expression) of Ang II in aorta associated with cytomegalovirus infection and infection
9) Confidence 0.06 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2673691 Disease Relevance 2.30 Pain Relevance 0.03
These results suggest that CMV infection induced renin and Ang II expression, and this underlies a molecular mechanism by which CMV infection causes an increase of blood pressure.


Positive_regulation (induced) of Gene_expression (expression) of Ang II in blood associated with pressure and volume under development, cytomegalovirus infection and infection
10) Confidence 0.06 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2673691 Disease Relevance 2.29 Pain Relevance 0.04
Despite a high basal level of Ang II expression in artery tissues, MCMV infection alone increased expression of Ang II in aorta samples and also exaggerated an increased expression of Ang II induced by high cholesterol diet (Fig. 5B).
Positive_regulation (induced) of Gene_expression (expression) of Ang II in aorta associated with cytomegalovirus infection and infection
11) Confidence 0.05 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2673691 Disease Relevance 2.25 Pain Relevance 0.03
To determine whether MCMV infection also changed expression of Ang II, we examined Ang II levels in mouse serum and in artery tissues.
Positive_regulation (changed) of Gene_expression (expression) of Ang II in artery associated with cytomegalovirus infection and infection
12) Confidence 0.05 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2673691 Disease Relevance 2.14 Pain Relevance 0
An increased expression of renin and Ang II has been known to cause an increase in blood pressure or hypertension in humans.
Positive_regulation (increased) of Gene_expression (expression) of Ang II in blood associated with pressure and volume under development
13) Confidence 0.05 Published 2009 Journal PLoS Pathogens Section Abstract Doc Link PMC2673691 Disease Relevance 2.65 Pain Relevance 0.08
Expression of viral genes and viral persistent infection of blood vessel endothelial cells resulting in an increased expression of inflammatory cytokines, including renin and Ang II, may underpin the molecular mechanism by which CMV infection induces an increase in blood pressure.



Positive_regulation (increased) of Gene_expression (expression) of Ang II in blood associated with pressure and volume under development, inflammation, cytomegalovirus infection, infection and cytokine
14) Confidence 0.05 Published 2009 Journal PLoS Pathogens Section Abstract Doc Link PMC2673691 Disease Relevance 2.51 Pain Relevance 0.10
MCMV infection induced expression of Ang II in mouse blood and artery tissues
Positive_regulation (induced) of in blood Gene_expression (expression) of Ang II in artery associated with cytomegalovirus infection and infection
15) Confidence 0.03 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2673691 Disease Relevance 2.33 Pain Relevance 0

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