INT149152

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Context Info
Confidence 0.58
First Reported 2008
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 5
Total Number 7
Disease Relevance 1.80
Pain Relevance 1.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Trpv4) cilium (Trpv4) transmembrane transport (Trpv4)
Anatomy Link Frequency
dorsal root ganglion 2
Trpv4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Taxol 90 99.80 Very High Very High Very High
dorsal root ganglion 70 99.44 Very High Very High Very High
allodynia 5 96.52 Very High Very High Very High
Calcium channel 2 96.20 Very High Very High Very High
Pain 43 91.08 High High
IPN 4 32.16 Quite Low
Hyperalgesia 13 25.00 Low Low
Inflammation 4 25.00 Low Low
imagery 36 5.00 Very Low Very Low Very Low
agonist 18 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Ganglion Cysts 70 99.44 Very High Very High Very High
Neuropathic Pain 20 96.52 Very High Very High Very High
Nociception 45 94.16 High High
Pain 40 91.08 High High
Shock 6 70.00 Quite High
Stress 4 69.28 Quite High
Pressure And Volume Under Development 1 67.44 Quite High
Inflammatory Pain 4 32.16 Quite Low
Hyperalgesia 13 5.00 Very Low Very Low Very Low
Adhesions 9 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Inhibition of TRPV4 activity was observed after transfection with both siRNA sequences.
Negative_regulation (Inhibition) of TRPV4
1) Confidence 0.58 Published 2010 Journal Neurol. Res. Section Body Doc Link 19278577 Disease Relevance 0.11 Pain Relevance 0
In this context, it is worth mentioning that recent studies demonstrate that point mutations located at these ankyrin repeats at the N-terminus either increase or decrease the TRPV4 activity and results in genetic disorders [71]–[73].
Negative_regulation (decrease) of TRPV4
2) Confidence 0.57 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2906515 Disease Relevance 0 Pain Relevance 0
Though the values are not statistically significant, these differences show a clear trend of Taxol-mediated inhibition of TRPV4.
Negative_regulation (inhibition) of TRPV4 associated with taxol
3) Confidence 0.57 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2906515 Disease Relevance 0.14 Pain Relevance 0.21
First, the levels of TRPV4 mRNA and protein expression in the dorsal root ganglion (DRG) were assessed using real-time RT-PCR and Western blotting analysis respectively at 7, 14, and 28 days post-CCD.
Negative_regulation (levels) of TRPV4 mRNA in dorsal root ganglion associated with ganglion cysts and dorsal root ganglion
4) Confidence 0.43 Published 2008 Journal Neurosci. Lett. Section Abstract Doc Link 18206306 Disease Relevance 0.95 Pain Relevance 0.60
Inhibition of the expression and function of TRPV4 by RNA interference in dorsal root ganglion.
Negative_regulation (Inhibition) of TRPV4 in dorsal root ganglion associated with ganglion cysts and dorsal root ganglion
5) Confidence 0.43 Published 2010 Journal Neurol. Res. Section Title Doc Link 19278577 Disease Relevance 0.47 Pain Relevance 0.41
Substitution of either tyrosine with phenylalanine led to a substantial reduction in the overall tyrosine phosphorylation level of TRPV4, suggesting that these two tyrosines constitute major phosphorylation sites.
Negative_regulation (reduction) of TRPV4
6) Confidence 0.43 Published 2009 Journal J. Biol. Chem. Section Abstract Doc Link 19033444 Disease Relevance 0.14 Pain Relevance 0
This suggests a partial inhibition of TRPV4 channel activity due to stabilization of microtubules.
Spec (partial) Negative_regulation (inhibition) of TRPV4
7) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2906515 Disease Relevance 0 Pain Relevance 0.30

General Comments

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