INT149153
From wiki-pain
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Sentences Mentioned In
Key: | Protein | Mutation | Event | Anatomy | Negation | Speculation | Pain term | Disease term |
An increased protein expression of Trpv4 was localized in the FSS-sensing endothelium by means of confocal immunohistochemistry. | |||||||||||||||
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Trpv4 expression as well as Ki67-positive staining was significantly increased in collateral vessels. | |||||||||||||||
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We studied the function of TRPV4 expression and its neuronal activation in response to noxious stimulation of oral mucosa. | |||||||||||||||
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Inhibition of TRPV4 activity was observed after transfection with both siRNA sequences. | |||||||||||||||
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Two days after transfection with TRPV4, the cells in either complete medium or in HBSS buffer were imaged at RT. | |||||||||||||||
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Both expression and activation of TRPV4 induces striking morphological changes affecting lamellipodial, filopodial, growth cone, and neurite structures in non-neuronal cells, in DRG-neuron derived F11 cells, and also in IB4-positive DRG neurons. | |||||||||||||||
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Activation of TRPV4 results in formation of elongated filopodia | |||||||||||||||
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The results showed that the levels of TRPV4 mRNA and protein expression increased significantly at 7-28 days post-CCD when compared with the sham group, with the highest level at 7 days post-CCD. | |||||||||||||||
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For expression of C-terminal cytoplasmic domain (amino acid residue 718 to 871) of TRPV4-fused with MBP, the corresponding cDNA region of TRPV4 (NCBI accession number AF263521) was amplified by using forward primer (5? | |||||||||||||||
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The purpose of TRPV4 overexpression in F-11 cells is to mimic the physiological situation in DRG neurons. | |||||||||||||||
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Both expression and activation of TRPV4 induces striking morphological changes affecting lamellipodial, filopodial, growth cone, and neurite structures in non-neuronal cells, in DRG-neuron derived F11 cells, and also in IB4-positive DRG neurons. | |||||||||||||||
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Both expression and activation of TRPV4 induces striking morphological changes affecting lamellipodial, filopodial, growth cone, and neurite structures in non-neuronal cells, in DRG-neuron derived F11 cells, and also in IB4-positive DRG neurons. | |||||||||||||||
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Both expression and activation of TRPV4 induces striking morphological changes affecting lamellipodial, filopodial, growth cone, and neurite structures in non-neuronal cells, in DRG-neuron derived F11 cells, and also in IB4-positive DRG neurons. | |||||||||||||||
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These data suggest that the conductance may be carried by TRPM3 or TRPV4 channels.
4 Unconventional ion channels | |||||||||||||||
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These data suggest that the conductance may be carried by TRPM3 or TRPV4 channels.
4 Unconventional ion channels | |||||||||||||||
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Both expression and activation of TRPV4 induces striking morphological changes affecting lamellipodial, filopodial, growth cone, and neurite structures in non-neuronal cells, in DRG-neuron derived F11 cells, and also in IB4-positive DRG neurons. | |||||||||||||||
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Both expression and activation of TRPV4 induces striking morphological changes affecting lamellipodial, filopodial, growth cone, and neurite structures in non-neuronal cells, in DRG-neuron derived F11 cells, and also in IB4-positive DRG neurons. | |||||||||||||||
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General Comments
This test has worked.