INT149153

Context Info Confidence 0.70 First Reported 2007 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 12 Total Number 17 Disease Relevance 3.37 Pain Relevance 1.72

plasma membrane (Trpv4) cilium (Trpv4) transmembrane transport (Trpv4)

Anatomy Link Frequency neurite 7 growth cone 5 neurons 2 vessels 2 endothelium 2 Trpv4 (Rattus norvegicus)

Pain Link Frequency Relevance Heat dorsal root ganglion 114 98.68 imagery 72 95.68 allodynia 5 89.60 member 8 2 83.92 agonist 50 83.52 Serotonin 7 81.12 5HT 4 80.24 Taxol 180 77.84 Pain 84 71.68 Hyperalgesia 30 62.36

Disease Link Frequency Relevance Heat Stress 24 99.80 Ganglion Cysts 114 98.68 Neuropathic Pain 35 89.60 Nociception 90 82.60 Pain 78 71.68 Hyperalgesia 30 62.36 Adhesions 18 32.32 INFLAMMATION 6 16.68 Cystic Fibrosis 22 5.00 Cancer 18 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

An increased protein expression of Trpv4 was localized in the FSS-sensing endothelium by means of confocal immunohistochemistry.

Positive_regulation (increased) of Gene_expression (expression) of Trpv4 in endothelium associated with stress

1) Confidence 0.70 Published 2009 Journal J. Cell. Mol. Med. Section Abstract Doc Link 19017361 Disease Relevance 0.45 Pain Relevance 0.08

Trpv4 expression as well as Ki67-positive staining was significantly increased in collateral vessels.

Positive_regulation (increased) of Gene_expression (expression) of Trpv4 in vessels

2) Confidence 0.70 Published 2009 Journal J. Cell. Mol. Med. Section Abstract Doc Link 19017361 Disease Relevance 0.49 Pain Relevance 0.06

We studied the function of TRPV4 expression and its neuronal activation in response to noxious stimulation of oral mucosa.

Positive_regulation (activation) of Gene_expression (expression) of TRPV4 in oral mucosa

3) Confidence 0.50 Published 2009 Journal Okajimas Folia Anat Jpn Section Abstract Doc Link 19877445 Disease Relevance 0.22 Pain Relevance 0.15

Inhibition of TRPV4 activity was observed after transfection with both siRNA sequences.

Positive_regulation (transfection) of Gene_expression (transfection) of TRPV4

4) Confidence 0.50 Published 2010 Journal Neurol. Res. Section Body Doc Link 19278577 Disease Relevance 0.11 Pain Relevance 0

Two days after transfection with TRPV4, the cells in either complete medium or in HBSS buffer were imaged at RT.

Positive_regulation (transfection) of Gene_expression (transfection) of TRPV4

5) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2906515 Disease Relevance 0 Pain Relevance 0.16

Both expression and activation of TRPV4 induces striking morphological changes affecting lamellipodial, filopodial, growth cone, and neurite structures in non-neuronal cells, in DRG-neuron derived F11 cells, and also in IB4-positive DRG neurons.

Positive_regulation (activation) of Gene_expression (expression) of TRPV4 in growth cone

6) Confidence 0.49 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2906515 Disease Relevance 0.14 Pain Relevance 0.14

Activation of TRPV4 results in formation of elongated filopodia

Positive_regulation (Activation) of Gene_expression (results) of TRPV4

7) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2906515 Disease Relevance 0 Pain Relevance 0

The results showed that the levels of TRPV4 mRNA and protein expression increased significantly at 7-28 days post-CCD when compared with the sham group, with the highest level at 7 days post-CCD.

Positive_regulation (increased) of Gene_expression (expression) of TRPV4 mRNA in CCD associated with dorsal root ganglion

8) Confidence 0.47 Published 2008 Journal Neurosci. Lett. Section Abstract Doc Link 18206306 Disease Relevance 1.47 Pain Relevance 0.86

For expression of C-terminal cytoplasmic domain (amino acid residue 718 to 871) of TRPV4-fused with MBP, the corresponding cDNA region of TRPV4 (NCBI accession number AF263521) was amplified by using forward primer (5?

Positive_regulation (amplified) of Gene_expression (expression) of TRPV4

9) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2906515 Disease Relevance 0 Pain Relevance 0

The purpose of TRPV4 overexpression in F-11 cells is to mimic the physiological situation in DRG neurons.

Positive_regulation (overexpression) of Gene_expression (overexpression) of TRPV4 in neurons associated with dorsal root ganglion

10) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2906515 Disease Relevance 0.10 Pain Relevance 0.08

Both expression and activation of TRPV4 induces striking morphological changes affecting lamellipodial, filopodial, growth cone, and neurite structures in non-neuronal cells, in DRG-neuron derived F11 cells, and also in IB4-positive DRG neurons.

Positive_regulation (activation) of Gene_expression (expression) of TRPV4 in neurite

11) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link 20657843 Disease Relevance 0.06 Pain Relevance 0

Both expression and activation of TRPV4 induces striking morphological changes affecting lamellipodial, filopodial, growth cone, and neurite structures in non-neuronal cells, in DRG-neuron derived F11 cells, and also in IB4-positive DRG neurons.

Positive_regulation (induces) of Gene_expression (expression) of TRPV4 in neurite

12) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link 20657843 Disease Relevance 0.06 Pain Relevance 0

Both expression and activation of TRPV4 induces striking morphological changes affecting lamellipodial, filopodial, growth cone, and neurite structures in non-neuronal cells, in DRG-neuron derived F11 cells, and also in IB4-positive DRG neurons.

Positive_regulation (activation) of in neurite Gene_expression (expression) of TRPV4 in growth cone

13) Confidence 0.17 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2906515 Disease Relevance 0.14 Pain Relevance 0.14

These data suggest that the conductance may be carried by TRPM3 or TRPV4 channels. 4 Unconventional ion channels

Positive_regulation (conductance) of Gene_expression (carried) of TRPV4

14) Confidence 0.16 Published 2007 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2072944 Disease Relevance 0 Pain Relevance 0.03

These data suggest that the conductance may be carried by TRPM3 or TRPV4 channels. 4 Unconventional ion channels

Positive_regulation (by) of Gene_expression (carried) of TRPV4

15) Confidence 0.16 Published 2007 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2072944 Disease Relevance 0 Pain Relevance 0.03

Both expression and activation of TRPV4 induces striking morphological changes affecting lamellipodial, filopodial, growth cone, and neurite structures in non-neuronal cells, in DRG-neuron derived F11 cells, and also in IB4-positive DRG neurons.

Positive_regulation (activation) of in growth cone Gene_expression (expression) of TRPV4 in neurite

16) Confidence 0.15 Published 2010 Journal PLoS ONE Section Body Doc Link 20657843 Disease Relevance 0.06 Pain Relevance 0

Both expression and activation of TRPV4 induces striking morphological changes affecting lamellipodial, filopodial, growth cone, and neurite structures in non-neuronal cells, in DRG-neuron derived F11 cells, and also in IB4-positive DRG neurons.

Positive_regulation (induces) of in growth cone Gene_expression (expression) of TRPV4 in neurite

17) Confidence 0.15 Published 2010 Journal PLoS ONE Section Body Doc Link 20657843 Disease Relevance 0.06 Pain Relevance 0

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