INT149192

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Context Info
Confidence 0.57
First Reported 2002
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.40
Pain Relevance 0.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (TNF, VCAM1) plasma membrane (TNF, VCAM1) aging (VCAM1)
intracellular (TNF) extracellular matrix organization (TNF) signal transduction (TNF)
Anatomy Link Frequency
endothelial cells 4
TNF (Homo sapiens)
VCAM1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 46 97.68 Very High Very High Very High
Inflammation 40 85.12 High High
rheumatoid arthritis 121 83.20 Quite High
antagonist 1 75.92 Quite High
Infliximab 5 72.64 Quite High
Etanercept 1 69.12 Quite High
Pain 2 59.84 Quite High
chemokine 31 57.20 Quite High
Morphine 2 50.00 Quite Low
isoflurane 2 50.00 Quite Low
Disease Link Frequency Relevance Heat
Syndrome 1 92.88 High High
Adhesions 58 91.04 High High
INFLAMMATION 40 85.12 High High
Adult Respiratory Distress Syndrome 67 84.00 Quite High
Rheumatoid Arthritis 121 83.20 Quite High
Critical Illness 1 78.56 Quite High
Pain 2 59.84 Quite High
Necrosis 7 50.00 Quite Low
Cancer 7 50.00 Quite Low
Apoptosis 5 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is known that endothelial cell activation and VCAM-1 expression is induced mainly by IL-1b and TNF-?.
TNF Positive_regulation (induced) of Gene_expression (expression) of VCAM-1 in endothelial cell
1) Confidence 0.57 Published 2002 Journal Respir Res Section Body Doc Link PMC150513 Disease Relevance 0.77 Pain Relevance 0.14
All four agents prevented TNF-alpha-induced mRNA and protein expression of intracellular cell adhesion molecule 1.
TNF-alpha Positive_regulation (induced) of Gene_expression (expression) of intracellular cell adhesion molecule 1
2) Confidence 0.39 Published 2008 Journal Anesthesiology Section Body Doc Link 18212564 Disease Relevance 0.07 Pain Relevance 0
In addition, IL-1 and TNF upregulate the expression of ICAM-1, VCAM-1 and E-selectin on endothelial cells, stimulating leukocyte migration into the joint [76,104].
TNF Positive_regulation (upregulate) of Gene_expression (expression) of VCAM in endothelial cells
3) Confidence 0.07 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC400438 Disease Relevance 0.56 Pain Relevance 0.62

General Comments

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