INT149196

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Context Info
Confidence 0.15
First Reported 2006
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.35
Pain Relevance 0.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (NFKB2) extracellular matrix organization (NFKB2) DNA binding (NFKB2)
cytoplasm (NFKB2) cytosol (NFKB2) signal transduction (NFKB2)
NFKB2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 21 97.20 Very High Very High Very High
Arthritis 14 88.80 High High
Inflammatory response 3 80.48 Quite High
Morphine 6 50.00 Quite Low
isoflurane 6 50.00 Quite Low
Opioid 3 50.00 Quite Low
rheumatoid arthritis 2 25.12 Quite Low
Bile 2 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Arthritis 27 99.04 Very High Very High Very High
INFLAMMATION 23 97.20 Very High Very High Very High
Adhesions 12 78.52 Quite High
Acquired Immune Deficiency Syndrome Or Hiv Infection 1 72.64 Quite High
Necrosis 7 72.48 Quite High
Cancer 7 72.12 Quite High
Hypersensitivity 1 55.08 Quite High
Experimental Arthritis 1 34.12 Quite Low
Rheumatoid Arthritis 2 25.12 Quite Low
Protozoal Infection 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
RESULTS: Tumor necrosis factor alpha significantly induced messenger RNA (mRNA) and protein expression of cell adhesion molecules as well as transcriptional activity of nuclear factor kappaB.
Transcription (activity) of nuclear factor kappaB
1) Confidence 0.15 Published 2008 Journal Anesthesiology Section Body Doc Link 18212564 Disease Relevance 0.07 Pain Relevance 0
They inhibit NFkB, a transcription factor which stimulates iNOS, an inducible enzyme which produces the inflammatory agent nitric oxide.
Transcription (transcription) of NFkB associated with inflammation
2) Confidence 0.14 Published 2006 Journal J Inflamm (Lond) Section Body Doc Link PMC1440857 Disease Relevance 1.15 Pain Relevance 0.31
TNF-alpha-induced transcriptional activity of nuclear factor kappaB was decreased by all four agents.
Transcription (activity) of nuclear factor kappaB
3) Confidence 0.12 Published 2008 Journal Anesthesiology Section Body Doc Link 18212564 Disease Relevance 0.05 Pain Relevance 0
Transcriptional activity of nuclear factor kappaB was assessed by infrared electrophoretic mobility shift assay.
Transcription (activity) of nuclear factor kappaB
4) Confidence 0.12 Published 2008 Journal Anesthesiology Section Body Doc Link 18212564 Disease Relevance 0.08 Pain Relevance 0

General Comments

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