INT149197

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Context Info
Confidence 0.25
First Reported 2006
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 14
Total Number 15
Disease Relevance 10.55
Pain Relevance 4.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (NFKB2) extracellular matrix organization (NFKB2) DNA binding (NFKB2)
cytoplasm (NFKB2) cytosol (NFKB2) signal transduction (NFKB2)
Anatomy Link Frequency
bladder 2
enterocytes 1
claw 1
body 1
NFKB2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 304 99.52 Very High Very High Very High
corticosteroid 112 99.40 Very High Very High Very High
Paracetamol 36 99.10 Very High Very High Very High
Inflammatory response 134 97.00 Very High Very High Very High
methotrexate 2 93.72 High High
cytokine 77 91.36 High High
rheumatoid arthritis 8 89.44 High High
Arthritis 56 89.12 High High
Inflammatory stimuli 70 73.88 Quite High
Inflammatory mediators 10 61.64 Quite High
Disease Link Frequency Relevance Heat
Congenital Anomalies 11 99.92 Very High Very High Very High
Apoptosis 40 99.82 Very High Very High Very High
INFLAMMATION 459 99.52 Very High Very High Very High
Cancer 126 99.44 Very High Very High Very High
Arthritis 108 99.36 Very High Very High Very High
Mucositis 57 99.32 Very High Very High Very High
Necrosis 11 99.20 Very High Very High Very High
Bladder Cancer 116 98.76 Very High Very High Very High
Appetite Loss 90 97.26 Very High Very High Very High
Toxicity 40 97.24 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
If we assume that corticosteroids instead of up-regulating the inhibitor of NFkB they prime the production rate of IL10 signaling (A), Figure 12 is extended to Figure 13.
Negative_regulation (inhibitor) of NFkB associated with corticosteroid
1) Confidence 0.25 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2651450 Disease Relevance 0.71 Pain Relevance 0.62
In this study, due to our inability to model all the mediators that may be affected by corticosteroids we opt to simulate the effect manifested by exogenous corticosteroids performing systematic perturbations on the primary inhibitor of NFkB, i.e.
Negative_regulation (inhibitor) of NFkB associated with corticosteroid
2) Confidence 0.25 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2651450 Disease Relevance 0.29 Pain Relevance 0.41
It also down-regulates the activity of NFkB.
Negative_regulation (regulates) of NFkB
3) Confidence 0.13 Published 2007 Journal Clin Exp Med Section Body Doc Link PMC2779346 Disease Relevance 0.45 Pain Relevance 0
It also down-regulates the activity of NFkB.
Negative_regulation (down) of NFkB
4) Confidence 0.13 Published 2007 Journal Clin Exp Med Section Body Doc Link PMC2779346 Disease Relevance 0.45 Pain Relevance 0
TNF-alpha-induced transcriptional activity of nuclear factor kappaB was decreased by all four agents.
Negative_regulation (decreased) of nuclear factor kappaB
5) Confidence 0.13 Published 2008 Journal Anesthesiology Section Body Doc Link 18212564 Disease Relevance 0.05 Pain Relevance 0
Paracetamol is not a potent inhibitor of cyclooxygenase (COX), but may inhibit NFkB, a transcription factor related to the inhibition of apoptosis [29], up-regulated in several cancers, including bladder cancer [30].
Spec (may) Negative_regulation (inhibit) of NFkB in bladder associated with paracetamol, cancer, bladder cancer and apoptosis
6) Confidence 0.12 Published 2007 Journal BMC Urol Section Body Doc Link PMC2018698 Disease Relevance 0.95 Pain Relevance 0.53
Thus, paracetamol, in theory, could promote apoptosis through NFkB inhibition conferring protection against bladder cancer, or conversely, could act as a bladder carcinogen through accumulation of DNA adducts from its toxic metabolite NAPQI.
Negative_regulation (inhibition) of NFkB in bladder associated with paracetamol, bladder cancer and apoptosis
7) Confidence 0.12 Published 2007 Journal BMC Urol Section Body Doc Link PMC2018698 Disease Relevance 0.97 Pain Relevance 0.85
Resveratrol and yucca phenolics strongly inhibit NFkB [34].
Negative_regulation (inhibit) of NFkB
8) Confidence 0.12 Published 2006 Journal J Inflamm (Lond) Section Body Doc Link PMC1440857 Disease Relevance 0.96 Pain Relevance 0.46
As reviewed by Miller et al. [42], cat's claw (Uncaria guianensis) "is a remarkably potent inhibitor of NFkB activity and tumor necrosis factor production."
Negative_regulation (inhibitor) of NFkB in claw associated with necrosis and cancer
9) Confidence 0.09 Published 2006 Journal J Inflamm (Lond) Section Body Doc Link PMC1440857 Disease Relevance 1.02 Pain Relevance 0.34
They inhibit NFkB, a transcription factor which stimulates iNOS, an inducible enzyme which produces the inflammatory agent nitric oxide.
Negative_regulation (inhibit) of NFkB associated with inflammation
10) Confidence 0.09 Published 2006 Journal J Inflamm (Lond) Section Body Doc Link PMC1440857 Disease Relevance 1.14 Pain Relevance 0.31
Thus, whole plant yucca powder has powerful anti-inflammatory activity, mediated via inhibition of NFkB activation.
Negative_regulation (inhibition) of NFkB associated with inflammation
11) Confidence 0.09 Published 2006 Journal J Inflamm (Lond) Section Body Doc Link PMC1440857 Disease Relevance 0.94 Pain Relevance 0.47
We propose that selective targeting of proteasome activity with a standardized dose of omega-3-acid ethyl esters, administered to cancer patients diagnosed with early stage CC, in addition to a standard intervention with nutritionally adequate diet and appetite stimulants, will alter metabolic abnormalities by downregulating NFkB, preventing the breakdown of myofibrillar proteins and resulting in increasing serum protein markers, lean body mass, and functional status.



Negative_regulation (downregulating) of NFkB in body associated with appetite loss, congenital anomalies and cancer
12) Confidence 0.07 Published 2010 Journal Curr Treat Options Oncol Section Abstract Doc Link PMC3016925 Disease Relevance 0.99 Pain Relevance 0.08
Treatment with NFkB inhibitors has been shown
Negative_regulation (inhibitors) of NFkB
13) Confidence 0.06 Published 2008 Journal Journal of Oncology Section Body Doc Link PMC2648637 Disease Relevance 0.85 Pain Relevance 0.27
To determine the transcription pattern of Nod-like receptors (NLRs) and inflammasome components (apoptosis-associated speck-like protein containing a CARD [ASC], CARD inhibitor of NFkB-activating ligands [Cardinal], and caspase?
Negative_regulation (inhibitor) of NFkB associated with apoptosis
14) Confidence 0.05 Published 2008 Journal Molecular Vision Section Abstract Doc Link PMC2526096 Disease Relevance 0.10 Pain Relevance 0
PAF caused a translocation of STAT3 from the cytosol to the nuclei of enterocytes and the PAF-induced induction of TLR4 expression was inhibited by pharmacological inhibition of the STAT3 and NFkB signaling pathways.


Negative_regulation (inhibition) of NFkB in enterocytes
15) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955554 Disease Relevance 0.66 Pain Relevance 0.14

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