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Context Info
Confidence 0.47
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.23
Pain Relevance 0.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Oprm1) plasma membrane (Oprm1) signal transducer activity (Oprm1)
Anatomy Link Frequency
paw 2
Oprm1 (Mus musculus)
Pain Link Frequency Relevance Heat
Cannabinoid 8 99.98 Very High Very High Very High
antagonist 3 85.88 High High
opioid receptor 4 75.00 Quite High
Cannabinoid receptor 2 75.00 Quite High
MU agonist 1 55.24 Quite High
analgesia 2 50.00 Quite Low
agonist 2 47.76 Quite Low
cannabis 1 44.44 Quite Low
Opioid 3 31.20 Quite Low
Central nervous system 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 4 96.52 Very High Very High Very High
Pain 1 5.00 Very Low Very Low Very Low
Herpes Simplex Virus 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
RESULTS: At 4 weeks after SGAMOR and SGMOR infection, decreased and increased muOR immunoreactivity was observed in ipsilateral dorsal hind paw skin, lumbar dorsal root ganglion cells, and superficial dorsal horns, respectively, compared with SGZ.
Positive_regulation (increased) of Regulation (immunoreactivity) of muOR in paw
1) Confidence 0.47 Published 2008 Journal Anesthesiology Section Body Doc Link 18212576 Disease Relevance 0 Pain Relevance 0
Taken together, these results indicate that acute treatment with cannabinoids causes alterations in MOR and DOR mRNA expression and functional activity in the cerebella of wild-type and CB1 knockout mice indicating indirect interactions between these two signaling systems.
Positive_regulation (causes) of Regulation (alterations) of MOR associated with targeted disruption and cannabinoid
2) Confidence 0.22 Published 2007 Journal Acta. Biol. Hung. Section Abstract Doc Link 18297798 Disease Relevance 0.23 Pain Relevance 0.42

General Comments

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