INT149198

Context Info Confidence 0.47 First Reported 2007 Last Reported 2008 Negated 0 Speculated 0 Reported most in Abstract Documents 2 Total Number 2 Disease Relevance 0.23 Pain Relevance 0.42

signal transduction (Oprm1) plasma membrane (Oprm1) signal transducer activity (Oprm1)

Anatomy Link Frequency paw 2 Oprm1 (Mus musculus)

Pain Link Frequency Relevance Heat Cannabinoid 8 99.98 antagonist 3 85.88 opioid receptor 4 75.00 Cannabinoid receptor 2 75.00 MU agonist 1 55.24 analgesia 2 50.00 agonist 2 47.76 cannabis 1 44.44 Opioid 3 31.20 Central nervous system 1 5.00

Disease Link Frequency Relevance Heat Targeted Disruption 4 96.52 Pain 1 5.00 Herpes Simplex Virus 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

RESULTS: At 4 weeks after SGAMOR and SGMOR infection, decreased and increased muOR immunoreactivity was observed in ipsilateral dorsal hind paw skin, lumbar dorsal root ganglion cells, and superficial dorsal horns, respectively, compared with SGZ.

Positive_regulation (increased) of Regulation (immunoreactivity) of muOR in paw

1) Confidence 0.47 Published 2008 Journal Anesthesiology Section Body Doc Link 18212576 Disease Relevance 0 Pain Relevance 0

Taken together, these results indicate that acute treatment with cannabinoids causes alterations in MOR and DOR mRNA expression and functional activity in the cerebella of wild-type and CB1 knockout mice indicating indirect interactions between these two signaling systems.

Positive_regulation (causes) of Regulation (alterations) of MOR associated with targeted disruption and cannabinoid

2) Confidence 0.22 Published 2007 Journal Acta. Biol. Hung. Section Abstract Doc Link 18297798 Disease Relevance 0.23 Pain Relevance 0.42

General Comments

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