INT149220

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Context Info
Confidence 0.35
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 3
Disease Relevance 0
Pain Relevance 0.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Trpc1, Trpc3) plasma membrane (Trpc1) protein complex (Trpc1)
transmembrane transport (Trpc1) cytoplasm (Trpc1)
Trpc1 (Mus musculus)
Trpc3 (Mus musculus)
Pain Link Frequency Relevance Heat
member 8 3 64.48 Quite High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
TRPC1 was identified as a potential physical link between TRPC3 and RyR1, as it interacted with both TRPC3 and RyR1, and JPs showed subtype-specific interactions with both RyR1 and TRPC3 (JP1-RyR1 and JP2-TRPC3).
TRPC1 Binding (link) of TRPC3
1) Confidence 0.35 Published 2008 Journal Biochem. J. Section Abstract Doc Link 18215135 Disease Relevance 0 Pain Relevance 0.06
TRPC1 was identified as a potential physical link between TRPC3 and RyR1, as it interacted with both TRPC3 and RyR1, and JPs showed subtype-specific interactions with both RyR1 and TRPC3 (JP1-RyR1 and JP2-TRPC3).
TRPC1 Binding (interacted) of TRPC3
2) Confidence 0.34 Published 2008 Journal Biochem. J. Section Abstract Doc Link 18215135 Disease Relevance 0 Pain Relevance 0.06
From these studies, we found that six triadic proteins, that are known to regulate RyR1 function and/or EC coupling [TRPC1, JP2 (junctophilin 2), homer, mitsugumin 29, calreticulin and calmodulin], interacted directly with TRPC3 in a Ca2+-independent manner.
TRPC1 Binding (interacted) of TRPC3
3) Confidence 0.34 Published 2008 Journal Biochem. J. Section Abstract Doc Link 18215135 Disease Relevance 0 Pain Relevance 0.06

General Comments

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