INT149221

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Context Info
Confidence 0.40
First Reported 2008
Last Reported 2009
Negated 1
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 0
Pain Relevance 0.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Ryr1, Trpc3) plasma membrane (Ryr1) cytoplasm (Ryr1)
Anatomy Link Frequency
skeletal muscle cell 1
skeletal muscle 1
reticulum 1
Ryr1 (Mus musculus)
Trpc3 (Mus musculus)
Pain Link Frequency Relevance Heat
member 8 5 98.16 Very High Very High Very High
Glutamate 2 75.00 Quite High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results support the hypothesis that TRPC3 and RyR1 are functionally engaged via linker proteins in skeletal muscle.
RyR1 Binding (engaged) of TRPC3 in skeletal muscle
1) Confidence 0.40 Published 2008 Journal Biochem. J. Section Abstract Doc Link 18215135 Disease Relevance 0 Pain Relevance 0
However we again found no direct interaction between TRPC3 and RyR1.
RyR1 Neg (no) Binding (interaction) of TRPC3
2) Confidence 0.40 Published 2008 Journal Biochem. J. Section Abstract Doc Link 18215135 Disease Relevance 0 Pain Relevance 0.06
However, it has not been possible to demonstrate direct protein-protein interactions between TRPC3 and RyR1.
RyR1 Binding (interactions) of TRPC3
3) Confidence 0.40 Published 2008 Journal Biochem. J. Section Abstract Doc Link 18215135 Disease Relevance 0 Pain Relevance 0.09
The expression of TRPC3 (canonical-type transient receptor potential cation channel type 3) is tightly regulated during skeletal muscle cell differentiation, and a functional interaction between TRPC3 and RyR1 [(ryanodine receptor type 1), an SR (sarcoplasmic reticulum) Ca2+-release channel] regulates the gain of SR Ca2+ release during EC (excitation-contraction) coupling.
RyR1 Binding (interaction) of TRPC3 in skeletal muscle cell associated with member 8
4) Confidence 0.40 Published 2008 Journal Biochem. J. Section Abstract Doc Link 18215135 Disease Relevance 0 Pain Relevance 0.10
In mouse skeletal myotubes, functional interaction between TRPC3 and RyR1 (ryanodine receptor type 1/Ca(2+)-release channel on sarcoplasmic reticulum membrane) regulates the gain of excitation-contraction coupling.
RyR1 Binding (interaction) of TRPC3 in reticulum
5) Confidence 0.32 Published 2009 Journal Mol. Cell. Biochem. Section Abstract Doc Link 19277847 Disease Relevance 0 Pain Relevance 0.13

General Comments

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