INT149236

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Context Info
Confidence 0.42
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.76
Pain Relevance 0.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Slc12a1) transmembrane transport (Slc12a1)
Anatomy Link Frequency
duct 2
Slc12a1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
COX-2 inhibitor 5 99.40 Very High Very High Very High
cINOD 3 86.96 High High
Disease Link Frequency Relevance Heat
Polyuria 3 99.82 Very High Very High Very High
Diabetes Insipidus 7 98.94 Very High Very High Very High
INFLAMMATION 1 86.40 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Because renal prostaglandins are derived largely from cyclooxygenase-2 (COX-2), we hypothesized that treatment of NDI with a COX-2 inhibitor may relieve polyuria through increased expression of Na-K-2Cl cotransporter type 2 (NKCC2) in the thick ascending limb and aquaporin-2 (AQP2) in the collecting duct.
Positive_regulation (increased) of Gene_expression (expression) of NKCC2 in duct associated with polyuria, diabetes insipidus and cox-2 inhibitor
1) Confidence 0.42 Published 2008 Journal Am. J. Physiol. Renal Physiol. Section Abstract Doc Link 18216147 Disease Relevance 0.76 Pain Relevance 0.32

General Comments

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