INT149237

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Context Info
Confidence 0.42
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 2.22
Pain Relevance 0.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
fibroblast 1
duct 1
Slc34a3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
COX-2 inhibitor 5 99.20 Very High Very High Very High
cINOD 3 86.56 High High
Pain 3 64.36 Quite High
abdominal pain 1 17.28 Low Low
colic 1 12.72 Low Low
Disease Link Frequency Relevance Heat
Polyuria 3 99.62 Very High Very High Very High
Diabetes Insipidus 7 98.74 Very High Very High Very High
Rickets 12 88.48 High High
INFLAMMATION 1 86.00 High High
Kidney Stones 22 85.12 High High
Hypophosphatemia 11 79.40 Quite High
Pain 3 64.36 Quite High
Disease 3 63.92 Quite High
Abdominal Pain 1 17.28 Low Low
Renal Colic 1 13.20 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The candidate gene region was narrowed to a 1.6 Mb region on chromosome 9q34, and the mutated gene was identified as the SLC34A3, which encodes the type 2c sodium phosphate cotransporter (NPT2c), that, with the NPT2a, is expressed at the apical domain of renal proximal tubular cells and reabsorb phosphate from the glomerular filtrate under the hormonal control of PTH and the fibroblast growth factor 23 (FGF23) [4-7].
Gene_expression (expressed) of SLC34A3 in fibroblast
1) Confidence 0.42 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC2821378 Disease Relevance 1.46 Pain Relevance 0.06
Because renal prostaglandins are derived largely from cyclooxygenase-2 (COX-2), we hypothesized that treatment of NDI with a COX-2 inhibitor may relieve polyuria through increased expression of Na-K-2Cl cotransporter type 2 (NKCC2) in the thick ascending limb and aquaporin-2 (AQP2) in the collecting duct.
Gene_expression (expression) of cotransporter type 2 in duct associated with polyuria, diabetes insipidus and cox-2 inhibitor
2) Confidence 0.08 Published 2008 Journal Am. J. Physiol. Renal Physiol. Section Abstract Doc Link 18216147 Disease Relevance 0.75 Pain Relevance 0.32

General Comments

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