INT149241

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Context Info
Confidence 0.45
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 4
Disease Relevance 1.05
Pain Relevance 0.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Slc12a1) transmembrane transport (Slc12a1)
Anatomy Link Frequency
kidney 1
Slc12a1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
COX-2 inhibitor 5 92.32 High High
cINOD 3 81.44 Quite High
anesthesia 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Polyuria 3 93.60 High High
Diabetes Insipidus 7 91.76 High High
Body Weight 12 73.36 Quite High
Kidney Stones 48 70.80 Quite High
INFLAMMATION 1 54.04 Quite High
Targeted Disruption 12 13.68 Low Low
Volume Depletion And Dehydration 6 5.00 Very Low Very Low Very Low
Hematuria 3 5.00 Very Low Very Low Very Low
Hypercalcemia 3 5.00 Very Low Very Low Very Low
Apoptosis 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Protein abundance of NHE3, NKCC2, and NCC was decreased in the high Ca-vitamin D group and was not changed by HCTZ.
Transcription (abundance) of NKCC2
1) Confidence 0.45 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2923802 Disease Relevance 0.13 Pain Relevance 0
Expression of NHE3, SGLT1, and NKCC2 mRNA was significantly decreased in the high Ca-vitamin D group, which increased when HCTZ was administered. mRNA expression results are summarized in Table 3.


Transcription (Expression) of NKCC2
2) Confidence 0.45 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2923802 Disease Relevance 0.13 Pain Relevance 0
Protein abundance of NHE3, SGLT1, and NKCC2 decreased in the hypercalciuric rats, and only SGLT1 protein abundance was increased by HCTZ in the hypercalciuric rats.
Transcription (abundance) of NKCC2
3) Confidence 0.45 Published 2010 Journal Journal of Korean Medical Science Section Abstract Doc Link PMC2923802 Disease Relevance 0.07 Pain Relevance 0
Semiquantitative immunoblotting using whole-kidney homogenates revealed that COX-2 inhibition caused significant increases in the abundance of AQP2 and NKCC2.
Transcription (abundance) of NKCC2 in kidney
4) Confidence 0.45 Published 2008 Journal Am. J. Physiol. Renal Physiol. Section Abstract Doc Link 18216147 Disease Relevance 0.72 Pain Relevance 0.39

General Comments

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