INT149242

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Context Info
Confidence 0.63
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.11
Pain Relevance 0.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Slc12a1) transmembrane transport (Slc12a1)
Anatomy Link Frequency
kidney 1
Slc12a1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
COX-2 inhibitor 5 92.32 High High
cINOD 3 81.44 Quite High
anesthesia 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Kidney Stones 32 99.12 Very High Very High Very High
Polyuria 3 93.60 High High
Diabetes Insipidus 7 91.76 High High
Targeted Disruption 8 58.12 Quite High
INFLAMMATION 1 54.04 Quite High
Body Weight 8 28.36 Quite Low
Volume Depletion And Dehydration 4 5.00 Very Low Very Low Very Low
Hematuria 2 5.00 Very Low Very Low Very Low
Hypercalcemia 2 5.00 Very Low Very Low Very Low
Apoptosis 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Concomitant administration of high calcium diet and vitamin D3 also decreased protein abundance of NHE3, SGLT1, NKCC2, and NCC.
Localization (abundance) of NKCC2
1) Confidence 0.63 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2923802 Disease Relevance 0.21 Pain Relevance 0
In our experiment, high calcium diet and vitamin D3 decreased protein abundance of TRPV5, NHE3, SGLT1, and NKCC2, resulting in severe hypercalciuria and the expression of TRPV5, NHE3, and NKCC2 was not restored by HCTZ administration.
Localization (abundance) of NKCC2 associated with kidney stones
2) Confidence 0.63 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2923802 Disease Relevance 0.19 Pain Relevance 0
Semiquantitative immunoblotting using whole-kidney homogenates revealed that COX-2 inhibition caused significant increases in the abundance of AQP2 and NKCC2.
Localization (abundance) of NKCC2 in kidney
3) Confidence 0.63 Published 2008 Journal Am. J. Physiol. Renal Physiol. Section Abstract Doc Link 18216147 Disease Relevance 0.72 Pain Relevance 0.39

General Comments

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