INT149243

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Context Info
Confidence 0.59
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.57
Pain Relevance 0.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Slc12a1) transmembrane transport (Slc12a1)
Slc12a1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
COX-2 inhibitor 10 99.54 Very High Very High Very High
cINOD 6 96.60 Very High Very High Very High
bDMF 10 80.84 Quite High
Limbic system 1 53.20 Quite High
Neuronal excitability 1 48.44 Quite Low
gABA 36 5.00 Very Low Very Low Very Low
Hippocampus 11 5.00 Very Low Very Low Very Low
agonist 6 5.00 Very Low Very Low Very Low
anticonvulsant 5 5.00 Very Low Very Low Very Low
GABAergic 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Polyuria 6 99.90 Very High Very High Very High
Diabetes Insipidus 14 99.56 Very High Very High Very High
Stress 2 97.02 Very High Very High Very High
INFLAMMATION 2 91.60 High High
Convulsion 30 50.00 Quite Low
Epilepsy 22 5.00 Very Low Very Low Very Low
Status Epilepticus 3 5.00 Very Low Very Low Very Low
Hypoxia 2 5.00 Very Low Very Low Very Low
Injury 2 5.00 Very Low Very Low Very Low
Cognitive Disorder 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Treating lithium-induced nephrogenic diabetes insipidus with a COX-2 inhibitor improves polyuria via upregulation of AQP2 and NKCC2.
Positive_regulation (upregulation) of NKCC2 associated with polyuria, diabetes insipidus and cox-2 inhibitor
1) Confidence 0.59 Published 2008 Journal Am. J. Physiol. Renal Physiol. Section Title Doc Link 18216147 Disease Relevance 0.74 Pain Relevance 0.33
The upregulation of AQP2 and NKCC2 in response to the COX-2 inhibitor may underlie the therapeutic mechanisms by which NSAIDs enhance antidiuresis in patients with NDI.
Positive_regulation (upregulation) of NKCC2 associated with diabetes insipidus, cinod and cox-2 inhibitor
2) Confidence 0.42 Published 2008 Journal Am. J. Physiol. Renal Physiol. Section Abstract Doc Link 18216147 Disease Relevance 0.73 Pain Relevance 0.30
Members of the serine-threonine kinase WNK (With No lysine (K)), SPAK (Serine Proline Alanine lysine (K) rich), and oxidative stress responsive (OSR) kinase families have drawn much focus in related research, showing that they are important, cooperatively or independently, in the activation of NKCC1, NKCC2, NCCs and de-activation of KCCs [77, 86, 134] [259] [57].
Positive_regulation (activation) of NKCC2 associated with stress
3) Confidence 0.16 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2645547 Disease Relevance 0.10 Pain Relevance 0.19

General Comments

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